Professionals Urge End to Water Fluoridation

Below abstract indicates that fluoride derivates can be used to damage
mito thus cause cell death.

Fluoride curcumin derivatives: new mitochondrial uncoupling agents.

The mitochondrial effects of two fluoride curcumin derivatives were
studied. They induced the collapse of mitochondrial membrane potential
(DeltaPsi), increased mitochondrial respiration, and decreased O(2)*-
production and promoted Ca(2+) release. These effects were reversed by
the recoupling agent 6-Ketocholestanol, but not by cyclosporin A, an
inhibitor of the permeability transition pore (PTP), suggesting that
these compounds act as uncoupling agents. This idea was reinforced by
the analysis of the physico-chemical properties of the compounds
indicating, that they are mainly in the anionic form in the
mitochondrial membrane. Moreover, they are able to induce PTP opening
by promoting the oxidation of thiol groups and the release of
cytochrome c, making these two molecules potential candidates for
induction of apoptosis. PMID: 15225605