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100% unvaccinated controls



 
 
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  #1  
Old July 29th 06, 08:11 AM posted to misc.kids.health,sci.med.immunology
john
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Posts: 265
Default 100% unvaccinated controls

Still waiting for that study using 100% unvaccinated controls. Just one.


  #2  
Old July 29th 06, 01:12 PM posted to misc.kids.health,sci.med.immunology
Jeff
external usenet poster
 
Posts: 780
Default 100% unvaccinated controls


"john" wrote in message
...
Still waiting for that study using 100% unvaccinated controls. Just one.


How about two:

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Citation

J Infect Dis. 1996 Nov;174 Suppl 3:S330-4.


Efficacy of high-titer live attenuated varicella vaccine in healthy young
children.

Varis T, Vesikari T.

Department of Virology, University of Tampere Medical School, Finland.

The efficacy of a high-titer, reformulated varicella vaccine was studied in
513 10- to 30-month-old children. Vaccinees were randomly allocated to 5
groups to receive one of two lots of an original high-titer vaccine, one of
two lots of a partially heat-inactivated vaccine, or placebo. Both vaccines
were well tolerated. Seroconversion was detected in 100% and 99% of children
immunized with the high- and low-titer vaccines, respectively. Sixty-five
cases of serologically confirmed varicella-like disease were discovered
during follow-up (mean, 29.3 months): 5 in the high-titer vaccine group, 19
in the low-titer vaccine group, and 41 in the placebo group (P or = .005
for each difference). Thus, the protective efficacy

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Citation

Vaccine. 1991 Sep;9(9):643-7.


Oka/Merck varicella vaccine in healthy children: final report of a 2-year
efficacy study and 7-year follow-up studies.

Kuter BJ, Weibel RE, Guess HA, Matthews H, Morton DH, Neff BJ, Provost PJ,
Watson BA, Starr SE, Plotkin SA.

Department of Clinical Research, Merck Sharp & Dohme Research Laboratories,
West Point, PA 19486.

A large double-blind, randomized, placebo-controlled trial of live
attenuated Oka/Merck varicella vaccine was conducted among healthy children,
1-14 years of age. During the first varicella season, the efficacy of the
vaccine among susceptible children was 100%1. During the second varicella
season, 22 children were diagnosed with varicella; 21 cases in placebo
recipients and one in a vaccine recipient. The overall efficacy of the
vaccine through two varicella seasons was 98%. After the code for the study
was broken, the original group of vaccine recipients continued to be
followed for development of varicella. The estimated proportion of vaccine
recipients who remained varicella-free at the end of 7 years was 95%. The 23
cases of varicella that occurred in vaccine recipients over the 7-year
period were considerably milder than natural varicella. The average number
of lesions was 53, 50% of the children had non-vesicular rashes, and 14% of
the children had a temperature greater than or equal to 38.9 degrees C (102
degrees F), oral. The persistence of antibody in a subset of vaccine
recipients followed for 6 years was 100%.


  #3  
Old July 29th 06, 09:36 PM posted to misc.kids.health,sci.med.immunology
john
external usenet poster
 
Posts: 265
Default 100% unvaccinated controls

they didn't have the varicella vax by the look of it, but they don't say
they didn't have any otehr vaccines, and I'd like to know what the placebo
was


"Jeff" wrote in message
nk.net...

"john" wrote in message
...
Still waiting for that study using 100% unvaccinated controls. Just one.


How about two:

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Citation

J Infect Dis. 1996 Nov;174 Suppl 3:S330-4.


Efficacy of high-titer live attenuated varicella vaccine in healthy young
children.

Varis T, Vesikari T.

Department of Virology, University of Tampere Medical School, Finland.

The efficacy of a high-titer, reformulated varicella vaccine was studied
in 513 10- to 30-month-old children. Vaccinees were randomly allocated to
5 groups to receive one of two lots of an original high-titer vaccine, one
of two lots of a partially heat-inactivated vaccine, or placebo. Both
vaccines were well tolerated. Seroconversion was detected in 100% and 99%
of children immunized with the high- and low-titer vaccines, respectively.
Sixty-five cases of serologically confirmed varicella-like disease were
discovered during follow-up (mean, 29.3 months): 5 in the high-titer
vaccine group, 19 in the low-titer vaccine group, and 41 in the placebo
group (P or = .005 for each difference). Thus, the protective efficacy

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Citation

Vaccine. 1991 Sep;9(9):643-7.


Oka/Merck varicella vaccine in healthy children: final report of a 2-year
efficacy study and 7-year follow-up studies.

Kuter BJ, Weibel RE, Guess HA, Matthews H, Morton DH, Neff BJ, Provost PJ,
Watson BA, Starr SE, Plotkin SA.

Department of Clinical Research, Merck Sharp & Dohme Research
Laboratories, West Point, PA 19486.

A large double-blind, randomized, placebo-controlled trial of live
attenuated Oka/Merck varicella vaccine was conducted among healthy
children, 1-14 years of age. During the first varicella season, the
efficacy of the vaccine among susceptible children was 100%1. During the
second varicella season, 22 children were diagnosed with varicella; 21
cases in placebo recipients and one in a vaccine recipient. The overall
efficacy of the vaccine through two varicella seasons was 98%. After the
code for the study was broken, the original group of vaccine recipients
continued to be followed for development of varicella. The estimated
proportion of vaccine recipients who remained varicella-free at the end of
7 years was 95%. The 23 cases of varicella that occurred in vaccine
recipients over the 7-year period were considerably milder than natural
varicella. The average number of lesions was 53, 50% of the children had
non-vesicular rashes, and 14% of the children had a temperature greater
than or equal to 38.9 degrees C (102 degrees F), oral. The persistence of
antibody in a subset of vaccine recipients followed for 6 years was 100%.



  #4  
Old July 29th 06, 11:15 PM posted to misc.kids.health,sci.med.immunology
Jeff
external usenet poster
 
Posts: 780
Default 100% unvaccinated controls


"john" wrote in message
...
they didn't have the varicella vax by the look of it, but they don't say
they didn't have any otehr vaccines, and I'd like to know what the placebo
was


What difference would it make if they had or had not other vaccines?

Why don't you read to orginal article to find out what hte placebo.

Jeff


  #5  
Old August 1st 06, 03:29 PM posted to misc.kids.health,sci.med.immunology
Bryan Heit
external usenet poster
 
Posts: 173
Default 100% unvaccinated controls

Jeff wrote:
"john" wrote in message
...

they didn't have the varicella vax by the look of it, but they don't say
they didn't have any otehr vaccines, and I'd like to know what the placebo
was



What difference would it make if they had or had not other vaccines?

Why don't you read to orginal article to find out what hte placebo.

Jeff



Because it would challenge his preconceptions. Same reason why he
doesn't read any of the scientific articles we post.

sarcasm Besides, they're all part of the conspiracy anyways /sarcasm.

Bryan
  #6  
Old August 2nd 06, 09:20 AM posted to misc.kids.health,sci.med.immunology
john
external usenet poster
 
Posts: 265
Default 100% unvaccinated controls


"Bryan Heit" wrote in message
...
Jeff wrote:
"john" wrote in message
...

they didn't have the varicella vax by the look of it, but they don't say
they didn't have any otehr vaccines, and I'd like to know what the
placebo was



What difference would it make if they had or had not other vaccines?

Why don't you read to orginal article to find out what hte placebo.

Jeff


Because it would challenge his preconceptions. Same reason why he doesn't
read any of the scientific articles we post.

sarcasm Besides, they're all part of the conspiracy anyways /sarcasm.

Bryan


can't find one?


 




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