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Anyone got a Hales?
Domperidone is a peripheral dopamine antagonist (similar to Reglan)
generally used for controlling nausea & vomiting, dyspepsia, and gastric reflux. It blocks peripheral dopamine receptors in the GI wall & in the CTZ (nausea center) in the brain stem and is currently used in Canada as an antiemetic. Unlike Reglan, it does not enter the brain compartment and it has few CNS effects such as depression. It is also known to produce significant increases in Prolactin levels and has proven useful as a galactagogue. Serum prolactin levels have been found to increase from 8.1 ng/mL to 124.1 ng/mL innon-lactating womenafter one 20 mg dose. Concentrations of domperidone reported in milk vary according to dose but following a dose of of 10 mg 3x daily, the average concentration in milk was only 2.6 ug/L. In a study by da Silva, 16 monthers with premature infants and lkow milk production (mean=112.8 mL/d in domperidone group; 48.2 mL/d in placebo group) were randomly chosen to receive placebo (n=9) or domperidone (10 mg TID) (n=7) for 7 days. Milk volume increased from 112.8 to 162.2 mL/d in the domperidone group and 48.2 to 56.1 mL/d in the placebo group. Prolactin levels increased from 12.9 to 119.3 ug/L in the domperidone group, and 15.6 to 18.1 ug/L in the placebo group. On day 5, the mean domperidone concentration was 6.6 ng/mL in plasma and 1.2 ng/mL in breastmilk of the treated group (n=6). No adverse effects were reported in infants or mothers. The usual oral dose for controlling GI distress is 10-20 mg three to four times daily although for nausea and vomiting the dose can be higher (up to 40mg). The galactagogue dose is suggested to be 10-20 mg orally 3-4 times daily. At present, this product is unavailable in the USA. Lactation Risk Category: L2 Theoretic Infant Dose: 0.4 ug/kg/day Adult Concerns: Dry Mouth, skin rash, itching, headache, thirst, abdominal cramps, diarrhea, drowsiness. Seizures have occured rarely. And a bunch of references which I doubt you'll need "Sarah Vaughan" wrote in message ... There is a discussion on one of the medical fora about use of Domperidone as a galactogogue. One problem is that the source most people have for information on safety of drugs in breastfeeding is the British National Formulary, which gives only very scanty information which is often largely based on CYA statements from manufacturers. Is there anyone with a Hales to hand who would be willing to post the information about Domperidone from there, so that I could copy and paste it on the forum? It would be useful to have an authoritative source. All the best, Sarah -- http://www.goodenoughmummy.typepad.com "That which can be destroyed by the truth, should be" - P. C. Hodgell |
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