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Link between High Levels of HtrA1 Protein and Preeclampsia
http://www.newswise.com/articles/view/517527/
Excerpts: ....Mayo Clinic researchers have found an association between abnormally high levels of a protein named HtrA1 and preeclampsia, a sudden and dangerous rise in blood pressure that can result in premature delivery, disability or death for mother and fetus. The condition, which affects 5 to 8 percent of pregnancies worldwide, constitutes a medical emergency and often requires a Caesarean section delivery. The condition is estimated to cause 50,000 to 76,000 maternal deaths each year... ....The Mayo Clinic work is the first to link high levels of HtrA1 in third-trimester placental tissues with severe preeclampsia. The results will be reported at the Society for Maternal-Fetal Medicine annual meeting in Miami... ....In the Mayo Clinic investigation into HtrA1 and preeclampsia, findings suggest that the increased levels of HtrA1 impair correct functioning during the second stage of growth of key placental cells called cytotrophoblasts. Their job is to invade the uterus to establish the placenta. Just how HtrA1 does this is not known. One possibility is that its molecules "fit" into place in the molecular puzzle to activate abnormal growth. This is theoretically possible because HtrA1 molecules are structurally similar to other molecules, insulin-like growth factors (IGF) binding proteins, according to the Mayo Clinic researchers. Research has shown that an excess IGF binding protein disrupts the growth of cytotrophoblasts and also leads to the dysfunction of the placenta and impaired fetal growth... -- C, mama to three year old nursling |
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Link between High Levels of HtrA1 Protein and Preeclampsia
writes:
: http://www.newswise.com/articles/view/517527/ : Excerpts: : ...Mayo Clinic researchers have found an association between abnormally : high levels of a protein named HtrA1 and preeclampsia, a sudden and : dangerous rise in blood pressure that can result in premature delivery, : disability or death for mother and fetus. The condition, which affects : 5 to 8 percent of pregnancies worldwide, constitutes a medical : emergency and often requires a Caesarean section delivery. The : condition is estimated to cause 50,000 to 76,000 maternal deaths each : year... This is great news! This gives us our first real chance at finding the mechanism by which PE gets established, and show a road forward to finding a solution. Hats off to Mayo. Keep up the good work! Larry |
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Link between High Levels of HtrA1 Protein and Preeclampsia
Ericka Kammerer wrote:
wrote: http://www.newswise.com/articles/view/517527/ Excerpts: ...Mayo Clinic researchers have found an association between abnormally high levels of a protein named HtrA1 and preeclampsia, Isn't this an exciting time for pre-eclampsia research?! One gets the feeling that they're finally really on to something, and that we might have at least early detection on the horizon! Pretty much everything since early 2003 has looked better and better. The initial sFlt-1 study was accepted for publication the day I transfered into the hospital. :-D -- C, mama to three year old nursling |
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