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Multiple Chemical Sensitivities and Immune System Dysregulation



 
 
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  #1  
Old November 25th 08, 01:46 AM posted to misc.health.alternative,talk.politics.medicine,misc.kids.health,alt.support.breast-implant
Ilena Rose
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Posts: 1,139
Default Multiple Chemical Sensitivities and Immune System Dysregulation

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Multiple Chemical Sensitivities
and Immune System Dysregulation
originally published as the Forword to A Consumer Guide for the
Chemically Sensitive (self-published by the authors) in 1982.

By Debra Lynn Dadd and Alan S. Levin, M.D.

Multiple chemical sensitivities is an illness involving intolerance of
certain chemicals found in the everyday environment. It is often
referred to as a new type of allergy, and is popularly known a variety
of names: environmental illness, ecologic illness, immunotoxic
syndrome, total allergy syndrome, cerebral allergy, or bioecologic
illness. Doctors who treat this disorder practice Environmental
Medicine, Clinical Ecology, Ecologic Medicine, or Bioecologic
Medicine.
Many physicians argue that multiple chemical sensitivities are not an
allergy at all, because reactions are not mediated by the same system
that causes traditional allergic reactions to pollens, dust, animal
dander, and molds. Technically they are correct; we now know that
multiple chemical sensitivities are the result of a different
malfunction of the immune system, recognized as a new and distinct
disorder known as "immune system dysregulation."
The traditional concept of allergy associates only a few specific
symptoms with a limited number of natural inhalants. In immune system
dysregulation, the immune system similarly loses its ability to
suppress unnecessary reactions, yet a much wider range of complex
symptoms results, involving a variety of organ systems. Furthermore,
these responses occur to a greater number of substances, including
certain toxic chemicals as well as foods and natural inhalants. The
most extreme manifestation of immune system dysregulation is universal
reactivity to everything in the external environment, and even to the
body's own tissues and organs.
SYMPTOMS
A substance can provoke any one or more of a number of symptoms in an
individual, including traditional "allergic" nasal stuffiness,
wheezing, sneezing, asthma, chronic sore throat, postnasal drip,
laryngitis, itching eyes, hives, and rashes. In addition,
gastrointestinal disturbances such as gastric irritation, bloating,
intermittent constipation or diarrhea, hemorrhoids, or anal bleeding
may occur. Musculoskeletal aches, pains, or twitching, and arthritis
or rheumatism are some other common reactions, as well as problems in
a host of other body systems, such as frequent or painful urination,
menstrual cramps, body or breath odors, metallic aftertaste,
sensitivity to light, visual disturbances, and ringing in the ears.
The most surprising and dramatic documented environmentally-induced
symptoms by far are the cerebral and behavioral reactions. These
include migraine headaches, fatigue, dizziness, learning disabilities,
confusion, inability to concentrate, lack of motivation, memory loss,
and dyslexia. Personality changes, mood swings, hyperactivity and
depression are also common.
In addition, another common behavioral symptom is insatiable hunger,
leading to incessant eating and often to obesity. Addictions to
specific foods, such as wheat, corn, sugar, coffee, and chocolate can
also develop, as well as addictions to alcoholic beverages, drugs,
tobacco, and even some common chemical vapors, such as perfume,
hairspray, or glue.
The same immune system dysregulation which causes multiple chemical
sensitivities is also believed by some scientists to be the
predecessor for such diseases as hypertension, rheumatoid arthritis,
coronary artery disease, and cancer. Immune system dysregulation may
also be directly responsible for certain symptoms associated with
other diseases such as infectious hepatitis, herpes, and infectious
mononucleosis. In addition, immune system dysregulation reduces the
immune system's ability to fight infection, leaving the body
vulnerable to various illnesses caused by bacteria, viruses, and
fungi.
DEVELOPMENT AND DIAGNOSIS
Immune system dysregulation can develop over a long period of time due
to repeated infectious diseases, continuous stress, and/or cumulative
exposure to toxic chemicals, even at the low levels found in our
everyday environment. It can also be triggered by ail single serious
viral infection, major stress, or massive chemical exposure.
Immune system dysregulation often remains undiagnosed, however,
because manv phvsicians, faced with its incredible array of seemingly
unrelated symptoms, and unfamiiliar with the available diagnostic
methods, rnisdiagnose it "stress", "psychosomatic disease," or the
like. The medications commonly prescribed for these problems may
suppress the symptoms to some extent, but often further aggravate the
problem without dealing with the underlying disease process at all.
HOW THE IMMUNE SYSTEM WORKS
It is important to comprehend how the immune system works in order to
understand how a simple malfunction can lead to such complex
reactivity and symptomatology. The immune system is the body's basic
defense against disease, providing protection by recognizing dangerous
bacteria or viruses which enter the body and rendering them harmless.
It works mainly through three kinds of white blood cells: B cells from
the bone marrow, T cells from the thymus, and macrophages from the
bone marrow and spleen.
B cells produce antibodies, proteins which circulate in the
bloodstream, locating and identifying foreign substances, which are
called antigens. When an antigen enters the body, B cells spring into
action, and produce specific antibodies which attach to the antigens
to form immune complexes. B cells are capable of producing a broad
range of specific antibodies which identify and bind not only to
disease producing viruses and fungi, but to non-disease producing
antigens as well. B cells are always ready to respond to foreign
substances: left to function on their own, they would continuously and
indiscriminately produce antibodies to all antigens, whether harmless
or dangerous.
T cells control the B cells. When a harmless substance enters the
body, the T cells signal the B cells to suppress antibody production,
yet when a dangerous substance enters and must be eliminated, the T
cells allow antibody production at a controlled rate and only until no
more are needed. T cells can be programmed through vaccination or
immunization to allow antibody production to previously unfamiliar but
harmful antigens such as smallpox or polio. Conversely, allergy shots
or other immunostimulation techniques can program T cells to recognize
harmless antigens and to suppress production of their antibodies.
The macrophages filter the immune complexes (formed by the combination
of foreign antigens with antibodies from the B cells) from the blood
and digest them into their component parts: proteins, carbohydrates,
and lipids. These components can then be either utilized as nutrients
or eliminated through the kidneys or gastrointestinal tract. The
inherent capacity of the macrophage system for processing immune
complexes varies among different individuals, and is determined by
heredity.
When a harmful antigen, such as a flu virus, enters the body, the T
cells allow the B cells to produce flu virus antibodies and attach
them to the flu virus antigens. After the resulting immune complexes
have been filtered out and digested by the macrophages, the body has
been effectively protected. When a substance such as wheat enters,
which the body does not need to be protected from, the T cells prevent
the B cells from producing wheat antibodies.
This same immune system mechanism which protects the body from disease
can, when malfunctioning, cause a broad range of symptoms in reaction
to a number of harmless or even beneficial substances entering the
body. This malfunction commonly originates when the T cells are
damaged by toxic chemicals, stress, and/or infectious disease. When
the normal complement of T cells is reduced in number, or when their
ability to function is impaired, they can no longer adequately control
B cell production of antibodies. Without this control, the B cells
cannot distinguish harmless dust, pollen, or animal hair, or vital and
nutritious foods, from toxic chemicals or life threatening bacteria or
viruses. They react by producing antibodies to all foreign substances
indiscriminately at an uncontrolled rate. Sometimes even
autoantibodies, which are antibodies directed against the body's own
tissues, are produced.
Unlimited antibody production leads to the formation of larger
quantities of immune complexes than the macrophages can process. When
the macrophages become overloaded, the excess immune complexes are
discharged into the bloodstream. These circulating immune complexes
can then cause symptoms in any part of the body fed by an artery or
capillary.
REVERSING THE CONDITION
This disease process can be effectively reversed by protecting the T
cells from stressful factors, allowing them to regenerate naturally
and resume their normal regulatory function. The most effective way to
accomplish this is a comprehensive reduction of all possible stresses
on the immune system, both physiological and psychological. Approaches
to consider include the following:

* Attitude - Develop a positive, productive attitude towards life;
cultivate a sense of responsibility and purpose, and seek socially
effective activities and interaction.
* Stress - Develop proper stress management techniques, and make
life changes necessary to reduce unwanted stress.
* Chemicals - Minimize exposure to toxic chemicals in air, foods,
and water. Live, eat, and work in the cleanest environment possible.
Avoid cigarette smoke particularly.
* Exercise - Include a program of regular exercise.
* Light - Ensure adequate exposure to the benefits of natural
light. Conventional fluorescent lights are a stress for many with
multiple chemical sensitivities.
* Harmful disease agents - Exposure to infectious bacteria,
viruses and fungi (particularly Candida albicans) should be avoided.
Effective treatment should be instituted for any existing disorders
from these agents. If you must be treated with antibiotics, be sure to
ask your doctor for an antifungal as well, to maintain proper balance
among intestinal flora. Have gamma globuen injections if you have been
exposed to mononucleosis or hepatitis. Avoid herpes infections.
* Food and nutrition - Obtain proper nutrition and avoid chemical
contaminants by eating a balanced diet of whole, naturally produced
foods. Avoid those foods which cause reactions, and rotate foods to
avoid development of new sensitivities. Use nutritional supplements if
individual needs exceed nutrients available from tolerated foods.
Remember that individuals with immune system problems often require
more of particular nutrients than the norm.
* Immunostimulation techniques - These include specific antigen
therapy (allergy shots) or nonspecific immunologic enhancement using
Transfer factor, Interferon, or Thymosin.

THE HEALING PROCESS
The actual healing process from immune system dysregulation is long,
slow, and punctuated by exasperating short-term setbacks. These
setbacks are inevitable, as the healing process invariably follows a
"roller coaster" pattern. The frequency, duration, and severity of
setbacks gradually diminishes until symptoms are mild and occur only
occasionally.
After recovery has begun, an individual will often begin to notice
adverse reactions to substances which previously caused no problems,
such as diesel fumes, air pollution, or fabric finishes. This
phenomenon, known as "masking", occurs when the elimination of
dominant exposures allows underlying sensitivities to become
temporarily more acute. This is to be expected; though it is sometimes
perceived as an increase of symptoms or severity of the disease, it
is, in fact, an indication of improvement.
Another aspect of the healing process is the experience of withdrawal
from previously unrecognized addictions. As in any traditional
addiction, the feeling of well being is maintained only through
continual re-exposure to the addicting agent. Upon avoidance, this
feeling of well being gives way to various symptoms, some of which may
be rather severe. This withdrawal may be experienced from a remarkably
wide variety of substances, including coffee, tobacco, alcoholic
beverages, many foods, and even some common chemicals. It is not
uncommon, for instance, to find an individual who is "addicted to his
work," the painter who "feels miserable" on weekends, or the printer
who stays drunk all during his vacation. Generally, however,
withdrawal symptoms last for only three to five days and then. if the
individual can avoid succumbing to temptation, the symptoms are
relieved. After having abstained for long periods, a formerly addicted
individual will usually have immediate and severe symptoms upon
re-exposure to the addicting agent, whether it be paint, cigarettes,
or wheat.
Rebuilding the immune system and regaining tolerance to chemicals and
other substances in the environment is a gradual process which may
take one or two years. During this time, avoidance of disease causing
agents and stress are crucial, but perhaps the most important
requisite for recovery is avoidance of the toxic chemicals found in
the everyday environment.
Even the elimination of a single significant chemical exposure (i.e.,
gas heat, smoking, or perfume) may immediately reduce symptoms and
allow the healing process to begin, but it is the continuous
protection of the immune system from chemical exposures of all kinds
which will allow tolerance and health to be regained. Remember,
however, that once the immune system has been damaged, it will always
remain vulnerable. Regardless of the level of tolerance achieved,
chemically sensitive individuals should continue to minimize chemical
exposures throughout their lives.
Once health is restored, occasional chemical exposures can be
tolerated, given an overall nontoxic lifestyle. The proper balance
must be maintained between these greater exposures and a generally low
baseline level of exposure, so that the immune system is wt overloaded
to the point of malfunctioning. For instance, if you must live in the
city and work in a toxic, poorly ventilated office environment, you
should spend as many breaks and lunch periods as possible away from
smoke-filled coffee rooms and outside in clean air--in a park, on a
roof garden, anywhere where you can breathe fresh outdoor air. You
should also live in as clean a house and location as possible, and
leave the city for unpolluted air whenever you can. If you suffer a
major exposure, such as being trapped behind a diesel truck in a
traffic jam for an extended period, you may require several hours at
the beach breathing clean air.
It is very likely that many individuals are needlessly suffering from
immune system dysregulation, without knowing about the disease or its
symptoms. Because anyone is susceptible to this illness, it is
beneficial for everyone to minimize exposure to toxic chemicals.
1. Biological Relevance of Immune Suppression as Induced by Genetic,
Therapeutic and Environmental Factors, Van Nostrand Reinhold Co., 135
West 50th Street, NY, NY 10020
2. Inadvertant Modification of the Immune Response: The Effects of
Foods, Drugs and Environmental Contaminants, Proc. F.D.A. - 4th
Science Symposium, Aug. 28-30, 1978
3. "Assessment of Environmental Contaminant-Induced Lymphocyte
Dysfunction," L.D. Loose, Environmental Health Perspectives 12
105-128, 1981
4. "Environmental Chemical Induced Macrophage Dysfunction", L.D.
Loose, J.B. Silkworth, T. Charbonneau and F. Blumenstock,
Environmental Health Perspectives 39 79-91, 1981
  #2  
Old November 25th 08, 10:24 PM posted to misc.health.alternative,talk.politics.medicine,misc.kids.health,alt.support.breast-implant
Mark Thorson
external usenet poster
 
Posts: 137
Default Multiple Chemical Sensitivities Caused By Child Abuse

Ilena Rose wrote:

Multiple Chemical Sensitivities
and Immune System Dysregulation
originally published as the Forword to A Consumer Guide for the
Chemically Sensitive (self-published by the authors) in 1982.


Much more reliable are peer-reviewed studies published
in reputable journals.

1982 was before the study which showed that many cases
of MCS are caused by childhood sexual abuse.


Ann Allergy 1993 Dec;71(6):538-46
Adult sequelae of childhood abuse presenting as
environmental illness.
Staudenmayer H, Selner ME, Selner JC.
Allergy Respiratory Institute of Colorado, Denver 80222.

Sixty-three patients with polysomatic complaints
attributed to sensitivity to environmental
chemicals had detailed clinical assessments and
diagnostic psychologic evaluations. Objective
medical parameters failed to substantiate their
beliefs that multiple chemicals were the cause of
their problems. A group of 64 patients with chronic
medical conditions and defined psychologic
disorders not attributed to chemical exposure
served as controls. Approximately half the patients
in each group underwent long-term psychotherapy,
and in these patients, the prevalence of
physical and sexual childhood abuse was significantly
higher (P .05) among the cohort of
women who attributed their symptoms to environmental
or chemically related illness. These data
suggest that somatization may reflect sequelae of
childhood abuse and may play an important role
in the illness experienced by women who believe
they are sensitive to environmental chemicals.
  #3  
Old November 25th 08, 10:24 PM posted to misc.health.alternative,talk.politics.medicine,misc.kids.health,alt.support.breast-implant
Mark Thorson
external usenet poster
 
Posts: 137
Default MCS Is Distress Expressed As Somatization

Ilena Rose wrote:

Multiple Chemical Sensitivities
and Immune System Dysregulation
originally published as the Forword to A Consumer Guide for the
Chemically Sensitive (self-published by the authors) in 1982.


Much more reliable are peer-reviewed studies published
in reputable journals.

J Psychosom Res. 2007 Jan;62(1):61-72.
MMPI-2 validity, clinical and content scales,
and the Fake Bad Scale for personal injury
litigants claiming idiopathic environmental
intolerance.
Staudenmayer H, Phillips S.
Behavioral Medicine Clinic, Denver, CO, USA.

BACKGROUND: Idiopathic environmental intolerance
(IEI) is a descriptor for nonspecific complaints
that are attributed to environmental exposure.

METHODS: The Minnesota Multiphasic Personality
Inventory 2 (MMPI-2) was administered to 50 female
and 20 male personal injury litigants alleging IEI.

RESULTS: The validity scales indicated no
overreporting of psychopathology. Half of the cases
had elevated scores on validity scales suggesting
defensiveness, and a large number had elevations on
Fake Bad Scale (FBS) suggesting overreporting of
unauthenticated symptoms. The average T-score
profile for females was defined by the two-point
code type 3-1 (Hysteria-Hypochondriasis), and the
average T-score profile for males was defined by
the three-point code type 3-1-2 (Hysteria,
Hypochondriasis-Depression). On the content scales,
Health Concerns (HEA) scale was significantly
elevated.

CONCLUSION: Idiopathic environmental intolerance
litigants (a) are more defensive about expressing
psychopathology, (b) express distress through
somatization, (c) use a self-serving
misrepresentation of exaggerated health concerns,
and (d) may exaggerate unauthenticated symptoms
suggesting malingering.
  #4  
Old November 25th 08, 10:24 PM posted to misc.health.alternative,talk.politics.medicine,misc.kids.health,alt.support.breast-implant
Mark Thorson
external usenet poster
 
Posts: 137
Default Multiple Chemical Sensitivities Associated With Psychosis

Ilena Rose wrote:

Multiple Chemical Sensitivities
and Immune System Dysregulation
originally published as the Forword to A Consumer Guide for the
Chemically Sensitive (self-published by the authors) in 1982.


Much more reliable are peer-reviewed studies published
in reputable journals.

J Occup Environ Med. 2006 Jan;48(1):76-82.
New aspects of psychiatric morbidity in idiopathic
environmental intolerances.
Hausteiner C, Mergeay A, Bornschein S, Zilker T,
Forstl H.
Department of Psychiatry and Psychotherapy,
Technical University Munich, Munich, Germany.

OBJECTIVE: To understand idiopathic environmental
intolerances (IEI)-formerly multiple chemical
sensitivities (MCS)-it is helpful to outline its
characteristic psychiatric morbidity.

METHOD: We applied a standardized interview
according to the Diagnostic and Statistical Manual
of Mental Disorders, 4th Edition (SCID) to 305
environmental patients with and without IEI.

RESULTS: Somatoform, affective and anxiety
disorders were the most frequent diagnoses but
only slightly differed between patients with or
without IEI. In both groups, current
substance-related disorders were rare. We found
a clearly higher prevalence of psychotic,
especially current delusional disorders, in IEI.

CONCLUSION: Somatization, depression, and anxiety
are frequent in IEI but nonspecific. Psychotic
disorders are more common in IEI than in other
types of environmental illness. It appears
worthwhile to study personality and cognitive
style to explain the pivotal features of IEI.
  #5  
Old November 25th 08, 10:24 PM posted to misc.health.alternative,talk.politics.medicine,misc.kids.health,alt.support.breast-implant
Mark Thorson
external usenet poster
 
Posts: 137
Default MCS Patients Have Moderate Psychopathology

Ilena Rose wrote:

Multiple Chemical Sensitivities
and Immune System Dysregulation
originally published as the Forword to A Consumer Guide for the
Chemically Sensitive (self-published by the authors) in 1982.


Much more reliable are peer-reviewed studies published
in reputable journals.

J Psychosom Res. 2006 Feb;60(2):199-209.
Chemosensory function and psychological profile
in patients with multiple chemical sensitivity:
comparison with odor-sensitive and asymptomatic
controls.
Papo D, Eberlein-Konig B, Berresheim HW,
Huss-Marp J, Grimm V, Ring J, Behrendt H,
Winneke G.
Division of Environmental Dermatology and
Allergology, GSF/TUM, Neuherberg-Munich, Germany.

OBJECTIVE: We addressed the question if patients
with multiple chemical sensitivity (MCS) differ
from participants with self-reported odor
sensitivity without MCS and asymptomatic
controls in terms of chemosensory, cognitive,
and clinical psychological endpoints.

METHODS: In a clinical study 23 MCS patients,
21 participants with self-reported odor
sensitivity, and 23 controls were investigated
using electrophysiological and psychophysical
olfactometric tests [chemosensory-event-related
potentials (CSERP), olfactory thresholds, odor
identification, trigeminal sensitivity]. The
participants filled in a mood list, a list of
complaints (BL), a Symptom Check List, a
State-Trait Anxiety Inventory (STAI), and an
MCS questionnaire.

RESULTS: The olfactometric investigations
revealed no significant differences between the
groups. The MCS group reached significantly
higher scores on negative mood states following
odorant exposure, on health complaints, global
indices, and the somatization subscale of the
Symptom Check List, trait and state anxiety and
symptoms, and triggering matters of the MCS
questionnaire.

CONCLUSIONS: Our findings reveal that neither
olfactory functions, nor chemosensory or
cognitive olfactory information processing are
impaired in MCS patients. They rather support
findings of altered psychological profile and
moderate psychopathology.
  #6  
Old November 25th 08, 10:24 PM posted to misc.health.alternative,talk.politics.medicine,misc.kids.health,alt.support.breast-implant
Mark Thorson
external usenet poster
 
Posts: 137
Default MCS Only Occurs When Chemicals Can Be Smelled

Ilena Rose wrote:

Multiple Chemical Sensitivities
and Immune System Dysregulation
originally published as the Forword to A Consumer Guide for the
Chemically Sensitive (self-published by the authors) in 1982.


Much more reliable are peer-reviewed studies published
in reputable journals.

J Allergy Clin Immunol. 2006 Dec;118(6):1257-64.
Multiple chemical sensitivities: A systematic review
of provocation studies.
Das-Munshi J, Rubin GJ, Wessely S.
Section of Epidemiology, Institute of Psychiatry,
London.

A systematic review of provocation studies of persons
reporting multiple chemical sensitivities (MCS) was
conducted from databases searched from inception to
May 2006. Thirty-seven studies were identified,
testing 784 persons reporting MCS, 547 control
subjects, and 180 individuals of whom a subset were
chemically sensitive. Blinding was inadequate in
most studies. In 21 studies odors of chemicals were
probably apparent; 19 of these reported positive
responses to provocations among chemically sensitive
individuals, and 1 study demonstrated that negative
expectations were significantly associated with
increased symptom reporting after provocations.
Seven studies used chemicals at or below odor
thresholds, and 6 failed to show consistent
responses among sensitive individuals after active
provocation. Six studies used forced-choice
discrimination and demonstrated that chemically
sensitive individuals were not better at detecting
odor thresholds than nonsensitive participants.
Three studies tested individuals by using nose
clips/face masks and confirmed response, possibly
mediated through eye exposure. Three studies used
olfactory masking agents to conceal stimuli, and
none of these found associations between
provocations and response. We conclude that
persons with MCS do react to chemical challenges;
however, these responses occur when they can
discern differences between active and sham
substances, suggesting that the mechanism of
action is not specific to the chemical itself
and might be related to expectations and prior
beliefs.
  #7  
Old November 25th 08, 10:24 PM posted to misc.health.alternative,talk.politics.medicine,misc.kids.health,alt.support.breast-implant
Mark Thorson
external usenet poster
 
Posts: 137
Default 75% of MCS Patients Have Another Psychiatric Disorder

Ilena Rose wrote:

Multiple Chemical Sensitivities
and Immune System Dysregulation
originally published as the Forword to A Consumer Guide for the
Chemically Sensitive (self-published by the authors) in 1982.


Much more reliable are peer-reviewed studies published
in reputable journals.

Psychol Med 2002 Nov;32(8):1387-94
Psychiatric and somatic disorders and multiple
chemical sensitivity (MCS) in 264 'environmental
patients'.
Bornschein S, Hausteiner C, Zilker T, Forstl H.
Psychiatric Clinic and Department of Toxicology,
I, Medical Clinic, Technical University of
Munich, Germany.

BACKGROUND: An increasing number of
individuals with diverse health complaints are
currently seeking help in the field of environmental
medicine. Multiple chemical sensitivity (MCS)
or idiopathic environmental intolerances (IEI)
is defined as an acquired disorder with multiple
recurrent symptoms associated with environmental
chemicals in low concentrations that are well
tolerated by the majority of people. Their symptoms
are not explained by any known psychiatric
or somatic disorder.

METHOD: Within a 2-year period we
examined 264 of 267 consecutive
patients prospectively presenting to a university
based out-patient department for environmental
medicine. Patients underwent routine medical
examination, toxicological analysis and the
structured clinical interview for DSM-IV
psychiatric disorders (SCID).

RESULTS: Seventy-five per cent of the patients
met DSM-IV criteria for at least one psychiatric
disorder and 35% of all patients suffered from
somatoform disorders. Other frequent diagnoses
were affective and anxiety disorders, and
dependence or substance abuse. In 39%
a psychiatric disorder, in 23% a somatic
condition and in 19% a combination of the two
were considered to provide sufficient
explanation of the symptoms. Toxic chemicals
were regarded as the most probable cause in only
five cases. The suspected diagnosis of MCS/IEI
could not be sustained in the vast majority of cases.

CONCLUSION: This investigation confirms
previous findings that psychiatric morbidity is
high in patients presenting to specialized centres
for environmental medicine. Somatoform
disorders are the leading diagnostic category,
and there is reason to believe that certain
'environmental' or MCS patients form a special
subgroup of somatoform disorders. In most
cases, symptoms can be explained by well-defined
psychiatric and medical conditions other than
MCS, which need specific treatment. Further
studies should focus on provocation testing in order
to find positive criteria for MCS and on therapeutic
approaches that consider psychiatric aspects.
  #8  
Old November 25th 08, 10:25 PM posted to misc.health.alternative,talk.politics.medicine,misc.kids.health,alt.support.breast-implant
Mark Thorson
external usenet poster
 
Posts: 137
Default 81.2% Of MCS Patients Have Long-Standing Psychiatric Disorders

Ilena Rose wrote:

Multiple Chemical Sensitivities
and Immune System Dysregulation
originally published as the Forword to A Consumer Guide for the
Chemically Sensitive (self-published by the authors) in 1982.


Much more reliable are peer-reviewed studies published
in reputable journals.

Psychother Psychosom Med Psychol. 2006 Mar-Apr;56(3-4):162-71.
[Psychiatric disorders of environmental outpatients--results
of the standardized psychiatric interview (CIDI) from the
German multi-center study on Multiple Chemical Sensitivity
(MCS)]
[Article in German]
Dietel A, Jordan L, Muhlinghaus T, Eikmann TF, Herr CE,
Nowak D, Pedrosa Gil F, Podoll K, Wiesmuller GA, Eis D.
Robert Koch-Institut, Fachgebiet 22/Umweltmedizin, Berlin.

BACKGROUND: A nationwide, environmental outpatient-based
multi-center two-phase study on Multiple Chemical
Sensitivity (MCS) was conducted from 1999 until 2004.
The aim of the study was to characterize more precisely
the health-complaints relevant for the MCS-phenomenon.
A standardized psychiatric interview (CIDI), used to
identify frequency, character and duration of psychiatric
disorders and their chronological relation to the
environment-related health complaints of the patients,
formed part of the extensive diagnostic procedure.

METHOD: 251 (86.3%) of the 291 attendees of the
environmental outpatient departments in Aachen, Berlin,
Bredstedt, Freiburg, Giessen and Munich, were examined
using the German version (M-CIDI/DIA-X) of the Composite
International Diagnostic Interview.

RESULTS: 83.7% (lifetime prevalence rate) fulfilled the
diagnostic criteria of at least one psychiatric disorder,
with the 12-month and 4-week prevalence rates being
76.5% and 64.5%, respectively. Environmental outpatients,
in all prevalence periods, had significantly higher rates
of psychiatric disorders than the comparable general
population. Somatoform disorders were most frequently
diagnosed, followed by depressive and phobic disorders.
For 81.2% of the patients the psychiatric disorder
started long before the environment-related health
complaints (average 17 years).

CONCLUSIONS: This study confirms the results of earlier
studies, i.e. that patients with environment-related
health complaints suffer from psychiatric disorders
more frequently than the general population. The high
environmental outpatients really suffer from
psychosomatic complaints, but attribute the causes to
the environment. Application of specific therapeutic
regimen is recommended for those patients, whose
psychiatric disorders are safeguarded diagnostically
and for whom a relevant exposure is unlikely.
  #9  
Old November 26th 08, 03:02 AM posted to misc.health.alternative,talk.politics.medicine,misc.kids.health,alt.support.breast-implant
Jan Drew
external usenet poster
 
Posts: 2,707
Default Multiple Chemical Sensitivities and Immune System Dysregulation

From: Ilena Rose
Date: Mon, 24 Nov 2008 18:46:26 -0600
Local: Mon, Nov 24 2008 7:46 pm
Subject: Multiple Chemical Sensitivities and Immune System Dysregulation

http://ilenarose.blogspot.com
Health Lover
www.BreastImplantAwareness.org/

Multiple Chemical Sensitivities
and Immune System Dysregulation
originally published as the Forword to A Consumer Guide for the
Chemically Sensitive (self-published by the authors) in 1982.


By Debra Lynn Dadd and Alan S. Levin, M.D.


Multiple chemical sensitivities is an illness involving intolerance of
certain chemicals found in the everyday environment. It is often
referred to as a new type of allergy, and is popularly known a variety
of names: environmental illness, ecologic illness, immunotoxic
syndrome, total allergy syndrome, cerebral allergy, or bioecologic
illness. Doctors who treat this disorder practice Environmental
Medicine, Clinical Ecology, Ecologic Medicine, or Bioecologic
Medicine.
Many physicians argue that multiple chemical sensitivities are not an
allergy at all, because reactions are not mediated by the same system
that causes traditional allergic reactions to pollens, dust, animal
dander, and molds. Technically they are correct; we now know that
multiple chemical sensitivities are the result of a different
malfunction of the immune system, recognized as a new and distinct
disorder known as "immune system dysregulation."
The traditional concept of allergy associates only a few specific
symptoms with a limited number of natural inhalants. In immune system
dysregulation, the immune system similarly loses its ability to
suppress unnecessary reactions, yet a much wider range of complex
symptoms results, involving a variety of organ systems. Furthermore,
these responses occur to a greater number of substances, including
certain toxic chemicals as well as foods and natural inhalants. The
most extreme manifestation of immune system dysregulation is universal
reactivity to everything in the external environment, and even to the
body's own tissues and organs.
SYMPTOMS
A substance can provoke any one or more of a number of symptoms in an
individual, including traditional "allergic" nasal stuffiness,
wheezing, sneezing, asthma, chronic sore throat, postnasal drip,
laryngitis, itching eyes, hives, and rashes. In addition,
gastrointestinal disturbances such as gastric irritation, bloating,
intermittent constipation or diarrhea, hemorrhoids, or anal bleeding
may occur. Musculoskeletal aches, pains, or twitching, and arthritis
or rheumatism are some other common reactions, as well as problems in
a host of other body systems, such as frequent or painful urination,
menstrual cramps, body or breath odors, metallic aftertaste,
sensitivity to light, visual disturbances, and ringing in the ears.
The most surprising and dramatic documented environmentally-induced
symptoms by far are the cerebral and behavioral reactions. These
include migraine headaches, fatigue, dizziness, learning disabilities,
confusion, inability to concentrate, lack of motivation, memory loss,
and dyslexia. Personality changes, mood swings, hyperactivity and
depression are also common.
In addition, another common behavioral symptom is insatiable hunger,
leading to incessant eating and often to obesity. Addictions to
specific foods, such as wheat, corn, sugar, coffee, and chocolate can
also develop, as well as addictions to alcoholic beverages, drugs,
tobacco, and even some common chemical vapors, such as perfume,
hairspray, or glue.
The same immune system dysregulation which causes multiple chemical
sensitivities is also believed by some scientists to be the
predecessor for such diseases as hypertension, rheumatoid arthritis,
coronary artery disease, and cancer. Immune system dysregulation may
also be directly responsible for certain symptoms associated with
other diseases such as infectious hepatitis, herpes, and infectious
mononucleosis. In addition, immune system dysregulation reduces the
immune system's ability to fight infection, leaving the body
vulnerable to various illnesses caused by bacteria, viruses, and
fungi.
DEVELOPMENT AND DIAGNOSIS
Immune system dysregulation can develop over a long period of time due
to repeated infectious diseases, continuous stress, and/or cumulative
exposure to toxic chemicals, even at the low levels found in our
everyday environment. It can also be triggered by ail single serious
viral infection, major stress, or massive chemical exposure.
Immune system dysregulation often remains undiagnosed, however,
because manv phvsicians, faced with its incredible array of seemingly
unrelated symptoms, and unfamiiliar with the available diagnostic
methods, rnisdiagnose it "stress", "psychosomatic disease," or the
like. The medications commonly prescribed for these problems may
suppress the symptoms to some extent, but often further aggravate the
problem without dealing with the underlying disease process at all.
HOW THE IMMUNE SYSTEM WORKS
It is important to comprehend how the immune system works in order to
understand how a simple malfunction can lead to such complex
reactivity and symptomatology. The immune system is the body's basic
defense against disease, providing protection by recognizing dangerous
bacteria or viruses which enter the body and rendering them harmless.
It works mainly through three kinds of white blood cells: B cells from
the bone marrow, T cells from the thymus, and macrophages from the
bone marrow and spleen.
B cells produce antibodies, proteins which circulate in the
bloodstream, locating and identifying foreign substances, which are
called antigens. When an antigen enters the body, B cells spring into
action, and produce specific antibodies which attach to the antigens
to form immune complexes. B cells are capable of producing a broad
range of specific antibodies which identify and bind not only to
disease producing viruses and fungi, but to non-disease producing
antigens as well. B cells are always ready to respond to foreign
substances: left to function on their own, they would continuously and
indiscriminately produce antibodies to all antigens, whether harmless
or dangerous.
T cells control the B cells. When a harmless substance enters the
body, the T cells signal the B cells to suppress antibody production,
yet when a dangerous substance enters and must be eliminated, the T
cells allow antibody production at a controlled rate and only until no
more are needed. T cells can be programmed through vaccination or
immunization to allow antibody production to previously unfamiliar but
harmful antigens such as smallpox or polio. Conversely, allergy shots
or other immunostimulation techniques can program T cells to recognize
harmless antigens and to suppress production of their antibodies.
The macrophages filter the immune complexes (formed by the combination
of foreign antigens with antibodies from the B cells) from the blood
and digest them into their component parts: proteins, carbohydrates,
and lipids. These components can then be either utilized as nutrients
or eliminated through the kidneys or gastrointestinal tract. The
inherent capacity of the macrophage system for processing immune
complexes varies among different individuals, and is determined by
heredity.
When a harmful antigen, such as a flu virus, enters the body, the T
cells allow the B cells to produce flu virus antibodies and attach
them to the flu virus antigens. After the resulting immune complexes
have been filtered out and digested by the macrophages, the body has
been effectively protected. When a substance such as wheat enters,
which the body does not need to be protected from, the T cells prevent
the B cells from producing wheat antibodies.
This same immune system mechanism which protects the body from disease
can, when malfunctioning, cause a broad range of symptoms in reaction
to a number of harmless or even beneficial substances entering the
body. This malfunction commonly originates when the T cells are
damaged by toxic chemicals, stress, and/or infectious disease. When
the normal complement of T cells is reduced in number, or when their
ability to function is impaired, they can no longer adequately control
B cell production of antibodies. Without this control, the B cells
cannot distinguish harmless dust, pollen, or animal hair, or vital and
nutritious foods, from toxic chemicals or life threatening bacteria or
viruses. They react by producing antibodies to all foreign substances
indiscriminately at an uncontrolled rate. Sometimes even
autoantibodies, which are antibodies directed against the body's own
tissues, are produced.
Unlimited antibody production leads to the formation of larger
quantities of immune complexes than the macrophages can process. When
the macrophages become overloaded, the excess immune complexes are
discharged into the bloodstream. These circulating immune complexes
can then cause symptoms in any part of the body fed by an artery or
capillary.
REVERSING THE CONDITION
This disease process can be effectively reversed by protecting the T
cells from stressful factors, allowing them to regenerate naturally
and resume their normal regulatory function. The most effective way to
accomplish this is a comprehensive reduction of all possible stresses
on the immune system, both physiological and psychological. Approaches
to consider include the following:


* Attitude - Develop a positive, productive attitude towards life;
cultivate a sense of responsibility and purpose, and seek socially
effective activities and interaction.
* Stress - Develop proper stress management techniques, and make
life changes necessary to reduce unwanted stress.
* Chemicals - Minimize exposure to toxic chemicals in air, foods,
and water. Live, eat, and work in the cleanest environment possible.
Avoid cigarette smoke particularly.
* Exercise - Include a program of regular exercise.
* Light - Ensure adequate exposure to the benefits of natural
light. Conventional fluorescent lights are a stress for many with
multiple chemical sensitivities.
* Harmful disease agents - Exposure to infectious bacteria,
viruses and fungi (particularly Candida albicans) should be avoided.
Effective treatment should be instituted for any existing disorders
from these agents. If you must be treated with antibiotics, be sure to
ask your doctor for an antifungal as well, to maintain proper balance
among intestinal flora. Have gamma globuen injections if you have been
exposed to mononucleosis or hepatitis. Avoid herpes infections.
* Food and nutrition - Obtain proper nutrition and avoid chemical
contaminants by eating a balanced diet of whole, naturally produced
foods. Avoid those foods which cause reactions, and rotate foods to
avoid development of new sensitivities. Use nutritional supplements if
individual needs exceed nutrients available from tolerated foods.
Remember that individuals with immune system problems often require
more of particular nutrients than the norm.
* Immunostimulation techniques - These include specific antigen
therapy (allergy shots) or nonspecific immunologic enhancement using
Transfer factor, Interferon, or Thymosin.


THE HEALING PROCESS
The actual healing process from immune system dysregulation is long,
slow, and punctuated by exasperating short-term setbacks. These
setbacks are inevitable, as the healing process invariably follows a
"roller coaster" pattern. The frequency, duration, and severity of
setbacks gradually diminishes until symptoms are mild and occur only
occasionally.
After recovery has begun, an individual will often begin to notice
adverse reactions to substances which previously caused no problems,
such as diesel fumes, air pollution, or fabric finishes. This
phenomenon, known as "masking", occurs when the elimination of
dominant exposures allows underlying sensitivities to become
temporarily more acute. This is to be expected; though it is sometimes
perceived as an increase of symptoms or severity of the disease, it
is, in fact, an indication of improvement.
Another aspect of the healing process is the experience of withdrawal
from previously unrecognized addictions. As in any traditional
addiction, the feeling of well being is maintained only through
continual re-exposure to the addicting agent. Upon avoidance, this
feeling of well being gives way to various symptoms, some of which may
be rather severe. This withdrawal may be experienced from a remarkably
wide variety of substances, including coffee, tobacco, alcoholic
beverages, many foods, and even some common chemicals. It is not
uncommon, for instance, to find an individual who is "addicted to his
work," the painter who "feels miserable" on weekends, or the printer
who stays drunk all during his vacation. Generally, however,
withdrawal symptoms last for only three to five days and then. if the
individual can avoid succumbing to temptation, the symptoms are
relieved. After having abstained for long periods, a formerly addicted
individual will usually have immediate and severe symptoms upon
re-exposure to the addicting agent, whether it be paint, cigarettes,
or wheat.
Rebuilding the immune system and regaining tolerance to chemicals and
other substances in the environment is a gradual process which may
take one or two years. During this time, avoidance of disease causing
agents and stress are crucial, but perhaps the most important
requisite for recovery is avoidance of the toxic chemicals found in
the everyday environment.
Even the elimination of a single significant chemical exposure (i.e.,
gas heat, smoking, or perfume) may immediately reduce symptoms and
allow the healing process to begin, but it is the continuous
protection of the immune system from chemical exposures of all kinds
which will allow tolerance and health to be regained. Remember,
however, that once the immune system has been damaged, it will always
remain vulnerable. Regardless of the level of tolerance achieved,
chemically sensitive individuals should continue to minimize chemical
exposures throughout their lives.
Once health is restored, occasional chemical exposures can be
tolerated, given an overall nontoxic lifestyle. The proper balance
must be maintained between these greater exposures and a generally low
baseline level of exposure, so that the immune system is wt overloaded
to the point of malfunctioning. For instance, if you must live in the
city and work in a toxic, poorly ventilated office environment, you
should spend as many breaks and lunch periods as possible away from
smoke-filled coffee rooms and outside in clean air--in a park, on a
roof garden, anywhere where you can breathe fresh outdoor air. You
should also live in as clean a house and location as possible, and
leave the city for unpolluted air whenever you can. If you suffer a
major exposure, such as being trapped behind a diesel truck in a
traffic jam for an extended period, you may require several hours at
the beach breathing clean air.
It is very likely that many individuals are needlessly suffering from
immune system dysregulation, without knowing about the disease or its
symptoms. Because anyone is susceptible to this illness, it is
beneficial for everyone to minimize exposure to toxic chemicals.
1. Biological Relevance of Immune Suppression as Induced by Genetic,
Therapeutic and Environmental Factors, Van Nostrand Reinhold Co., 135
West 50th Street, NY, NY 10020
2. Inadvertant Modification of the Immune Response: The Effects of
Foods, Drugs and Environmental Contaminants, Proc. F.D.A. - 4th
Science Symposium, Aug. 28-30, 1978
3. "Assessment of Environmental Contaminant-Induced Lymphocyte
Dysfunction," L.D. Loose, Environmental Health Perspectives 12
105-128, 1981
4. "Environmental Chemical Induced Macrophage Dysfunction", L.D.
Loose, J.B. Silkworth, T. Charbonneau and F. Blumenstock,
Environmental Health Perspectives 39 79-91, 1981






  #10  
Old November 26th 08, 03:05 AM posted to misc.health.alternative,talk.politics.medicine,misc.kids.health,alt.support.breast-implant
Jan Drew
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Posts: 2,707
Default Multiple Chemical Sensitivities and Immune System Dysregulation

From: Ilena Rose
Date: Mon, 24 Nov 2008 18:46:26 -0600
Local: Mon, Nov 24 2008 7:46 pm
Subject: Multiple Chemical Sensitivities and Immune System Dysregulation

http://ilenarose.blogspot.com
Health Lover
www.BreastImplantAwareness.org/

Multiple Chemical Sensitivities
and Immune System Dysregulation
originally published as the Forword to A Consumer Guide for the
Chemically Sensitive (self-published by the authors) in 1982.


By Debra Lynn Dadd and Alan S. Levin, M.D.


Multiple chemical sensitivities is an illness involving intolerance of
certain chemicals found in the everyday environment. It is often
referred to as a new type of allergy, and is popularly known a variety
of names: environmental illness, ecologic illness, immunotoxic
syndrome, total allergy syndrome, cerebral allergy, or bioecologic
illness. Doctors who treat this disorder practice Environmental
Medicine, Clinical Ecology, Ecologic Medicine, or Bioecologic
Medicine.
Many physicians argue that multiple chemical sensitivities are not an
allergy at all, because reactions are not mediated by the same system
that causes traditional allergic reactions to pollens, dust, animal
dander, and molds. Technically they are correct; we now know that
multiple chemical sensitivities are the result of a different
malfunction of the immune system, recognized as a new and distinct
disorder known as "immune system dysregulation."
The traditional concept of allergy associates only a few specific
symptoms with a limited number of natural inhalants. In immune system
dysregulation, the immune system similarly loses its ability to
suppress unnecessary reactions, yet a much wider range of complex
symptoms results, involving a variety of organ systems. Furthermore,
these responses occur to a greater number of substances, including
certain toxic chemicals as well as foods and natural inhalants. The
most extreme manifestation of immune system dysregulation is universal
reactivity to everything in the external environment, and even to the
body's own tissues and organs.
SYMPTOMS
A substance can provoke any one or more of a number of symptoms in an
individual, including traditional "allergic" nasal stuffiness,
wheezing, sneezing, asthma, chronic sore throat, postnasal drip,
laryngitis, itching eyes, hives, and rashes. In addition,
gastrointestinal disturbances such as gastric irritation, bloating,
intermittent constipation or diarrhea, hemorrhoids, or anal bleeding
may occur. Musculoskeletal aches, pains, or twitching, and arthritis
or rheumatism are some other common reactions, as well as problems in
a host of other body systems, such as frequent or painful urination,
menstrual cramps, body or breath odors, metallic aftertaste,
sensitivity to light, visual disturbances, and ringing in the ears.
The most surprising and dramatic documented environmentally-induced
symptoms by far are the cerebral and behavioral reactions. These
include migraine headaches, fatigue, dizziness, learning disabilities,
confusion, inability to concentrate, lack of motivation, memory loss,
and dyslexia. Personality changes, mood swings, hyperactivity and
depression are also common.
In addition, another common behavioral symptom is insatiable hunger,
leading to incessant eating and often to obesity. Addictions to
specific foods, such as wheat, corn, sugar, coffee, and chocolate can
also develop, as well as addictions to alcoholic beverages, drugs,
tobacco, and even some common chemical vapors, such as perfume,
hairspray, or glue.
The same immune system dysregulation which causes multiple chemical
sensitivities is also believed by some scientists to be the
predecessor for such diseases as hypertension, rheumatoid arthritis,
coronary artery disease, and cancer. Immune system dysregulation may
also be directly responsible for certain symptoms associated with
other diseases such as infectious hepatitis, herpes, and infectious
mononucleosis. In addition, immune system dysregulation reduces the
immune system's ability to fight infection, leaving the body
vulnerable to various illnesses caused by bacteria, viruses, and
fungi.
DEVELOPMENT AND DIAGNOSIS
Immune system dysregulation can develop over a long period of time due
to repeated infectious diseases, continuous stress, and/or cumulative
exposure to toxic chemicals, even at the low levels found in our
everyday environment. It can also be triggered by ail single serious
viral infection, major stress, or massive chemical exposure.
Immune system dysregulation often remains undiagnosed, however,
because manv phvsicians, faced with its incredible array of seemingly
unrelated symptoms, and unfamiiliar with the available diagnostic
methods, rnisdiagnose it "stress", "psychosomatic disease," or the
like. The medications commonly prescribed for these problems may
suppress the symptoms to some extent, but often further aggravate the
problem without dealing with the underlying disease process at all.
HOW THE IMMUNE SYSTEM WORKS
It is important to comprehend how the immune system works in order to
understand how a simple malfunction can lead to such complex
reactivity and symptomatology. The immune system is the body's basic
defense against disease, providing protection by recognizing dangerous
bacteria or viruses which enter the body and rendering them harmless.
It works mainly through three kinds of white blood cells: B cells from
the bone marrow, T cells from the thymus, and macrophages from the
bone marrow and spleen.
B cells produce antibodies, proteins which circulate in the
bloodstream, locating and identifying foreign substances, which are
called antigens. When an antigen enters the body, B cells spring into
action, and produce specific antibodies which attach to the antigens
to form immune complexes. B cells are capable of producing a broad
range of specific antibodies which identify and bind not only to
disease producing viruses and fungi, but to non-disease producing
antigens as well. B cells are always ready to respond to foreign
substances: left to function on their own, they would continuously and
indiscriminately produce antibodies to all antigens, whether harmless
or dangerous.
T cells control the B cells. When a harmless substance enters the
body, the T cells signal the B cells to suppress antibody production,
yet when a dangerous substance enters and must be eliminated, the T
cells allow antibody production at a controlled rate and only until no
more are needed. T cells can be programmed through vaccination or
immunization to allow antibody production to previously unfamiliar but
harmful antigens such as smallpox or polio. Conversely, allergy shots
or other immunostimulation techniques can program T cells to recognize
harmless antigens and to suppress production of their antibodies.
The macrophages filter the immune complexes (formed by the combination
of foreign antigens with antibodies from the B cells) from the blood
and digest them into their component parts: proteins, carbohydrates,
and lipids. These components can then be either utilized as nutrients
or eliminated through the kidneys or gastrointestinal tract. The
inherent capacity of the macrophage system for processing immune
complexes varies among different individuals, and is determined by
heredity.
When a harmful antigen, such as a flu virus, enters the body, the T
cells allow the B cells to produce flu virus antibodies and attach
them to the flu virus antigens. After the resulting immune complexes
have been filtered out and digested by the macrophages, the body has
been effectively protected. When a substance such as wheat enters,
which the body does not need to be protected from, the T cells prevent
the B cells from producing wheat antibodies.
This same immune system mechanism which protects the body from disease
can, when malfunctioning, cause a broad range of symptoms in reaction
to a number of harmless or even beneficial substances entering the
body. This malfunction commonly originates when the T cells are
damaged by toxic chemicals, stress, and/or infectious disease. When
the normal complement of T cells is reduced in number, or when their
ability to function is impaired, they can no longer adequately control
B cell production of antibodies. Without this control, the B cells
cannot distinguish harmless dust, pollen, or animal hair, or vital and
nutritious foods, from toxic chemicals or life threatening bacteria or
viruses. They react by producing antibodies to all foreign substances
indiscriminately at an uncontrolled rate. Sometimes even
autoantibodies, which are antibodies directed against the body's own
tissues, are produced.
Unlimited antibody production leads to the formation of larger
quantities of immune complexes than the macrophages can process. When
the macrophages become overloaded, the excess immune complexes are
discharged into the bloodstream. These circulating immune complexes
can then cause symptoms in any part of the body fed by an artery or
capillary.
REVERSING THE CONDITION
This disease process can be effectively reversed by protecting the T
cells from stressful factors, allowing them to regenerate naturally
and resume their normal regulatory function. The most effective way to
accomplish this is a comprehensive reduction of all possible stresses
on the immune system, both physiological and psychological. Approaches
to consider include the following:


* Attitude - Develop a positive, productive attitude towards life;
cultivate a sense of responsibility and purpose, and seek socially
effective activities and interaction.
* Stress - Develop proper stress management techniques, and make
life changes necessary to reduce unwanted stress.
* Chemicals - Minimize exposure to toxic chemicals in air, foods,
and water. Live, eat, and work in the cleanest environment possible.
Avoid cigarette smoke particularly.
* Exercise - Include a program of regular exercise.
* Light - Ensure adequate exposure to the benefits of natural
light. Conventional fluorescent lights are a stress for many with
multiple chemical sensitivities.
* Harmful disease agents - Exposure to infectious bacteria,
viruses and fungi (particularly Candida albicans) should be avoided.
Effective treatment should be instituted for any existing disorders
from these agents. If you must be treated with antibiotics, be sure to
ask your doctor for an antifungal as well, to maintain proper balance
among intestinal flora. Have gamma globuen injections if you have been
exposed to mononucleosis or hepatitis. Avoid herpes infections.
* Food and nutrition - Obtain proper nutrition and avoid chemical
contaminants by eating a balanced diet of whole, naturally produced
foods. Avoid those foods which cause reactions, and rotate foods to
avoid development of new sensitivities. Use nutritional supplements if
individual needs exceed nutrients available from tolerated foods.
Remember that individuals with immune system problems often require
more of particular nutrients than the norm.
* Immunostimulation techniques - These include specific antigen
therapy (allergy shots) or nonspecific immunologic enhancement using
Transfer factor, Interferon, or Thymosin.


THE HEALING PROCESS
The actual healing process from immune system dysregulation is long,
slow, and punctuated by exasperating short-term setbacks. These
setbacks are inevitable, as the healing process invariably follows a
"roller coaster" pattern. The frequency, duration, and severity of
setbacks gradually diminishes until symptoms are mild and occur only
occasionally.
After recovery has begun, an individual will often begin to notice
adverse reactions to substances which previously caused no problems,
such as diesel fumes, air pollution, or fabric finishes. This
phenomenon, known as "masking", occurs when the elimination of
dominant exposures allows underlying sensitivities to become
temporarily more acute. This is to be expected; though it is sometimes
perceived as an increase of symptoms or severity of the disease, it
is, in fact, an indication of improvement.
Another aspect of the healing process is the experience of withdrawal
from previously unrecognized addictions. As in any traditional
addiction, the feeling of well being is maintained only through
continual re-exposure to the addicting agent. Upon avoidance, this
feeling of well being gives way to various symptoms, some of which may
be rather severe. This withdrawal may be experienced from a remarkably
wide variety of substances, including coffee, tobacco, alcoholic
beverages, many foods, and even some common chemicals. It is not
uncommon, for instance, to find an individual who is "addicted to his
work," the painter who "feels miserable" on weekends, or the printer
who stays drunk all during his vacation. Generally, however,
withdrawal symptoms last for only three to five days and then. if the
individual can avoid succumbing to temptation, the symptoms are
relieved. After having abstained for long periods, a formerly addicted
individual will usually have immediate and severe symptoms upon
re-exposure to the addicting agent, whether it be paint, cigarettes,
or wheat.
Rebuilding the immune system and regaining tolerance to chemicals and
other substances in the environment is a gradual process which may
take one or two years. During this time, avoidance of disease causing
agents and stress are crucial, but perhaps the most important
requisite for recovery is avoidance of the toxic chemicals found in
the everyday environment.
Even the elimination of a single significant chemical exposure (i.e.,
gas heat, smoking, or perfume) may immediately reduce symptoms and
allow the healing process to begin, but it is the continuous
protection of the immune system from chemical exposures of all kinds
which will allow tolerance and health to be regained. Remember,
however, that once the immune system has been damaged, it will always
remain vulnerable. Regardless of the level of tolerance achieved,
chemically sensitive individuals should continue to minimize chemical
exposures throughout their lives.
Once health is restored, occasional chemical exposures can be
tolerated, given an overall nontoxic lifestyle. The proper balance
must be maintained between these greater exposures and a generally low
baseline level of exposure, so that the immune system is wt overloaded
to the point of malfunctioning. For instance, if you must live in the
city and work in a toxic, poorly ventilated office environment, you
should spend as many breaks and lunch periods as possible away from
smoke-filled coffee rooms and outside in clean air--in a park, on a
roof garden, anywhere where you can breathe fresh outdoor air. You
should also live in as clean a house and location as possible, and
leave the city for unpolluted air whenever you can. If you suffer a
major exposure, such as being trapped behind a diesel truck in a
traffic jam for an extended period, you may require several hours at
the beach breathing clean air.
It is very likely that many individuals are needlessly suffering from
immune system dysregulation, without knowing about the disease or its
symptoms. Because anyone is susceptible to this illness, it is
beneficial for everyone to minimize exposure to toxic chemicals.
1. Biological Relevance of Immune Suppression as Induced by Genetic,
Therapeutic and Environmental Factors, Van Nostrand Reinhold Co., 135
West 50th Street, NY, NY 10020
2. Inadvertant Modification of the Immune Response: The Effects of
Foods, Drugs and Environmental Contaminants, Proc. F.D.A. - 4th
Science Symposium, Aug. 28-30, 1978
3. "Assessment of Environmental Contaminant-Induced Lymphocyte
Dysfunction," L.D. Loose, Environmental Health Perspectives 12
105-128, 1981
4. "Environmental Chemical Induced Macrophage Dysfunction", L.D.
Loose, J.B. Silkworth, T. Charbonneau and F. Blumenstock,
Environmental Health Perspectives 39 79-91, 1981

 




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