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Dentists Oppose Fluoridation; You Should Too



 
 
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  #1  
Old February 24th 08, 03:15 PM posted to misc.kids.breastfeeding,misc.kids.health,sci.med.nutrition,talk.environment,misc.kids.pregnancy
NYSCOF
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Posts: 6
Default Dentists Oppose Fluoridation; You Should Too

Two hundred and eleven dentists signed a statement asking Congress to
ban water fluoridation. And, according to the Wealthy Dentist, 15% of
dentists oppose water fluoridation.

Professionals Urge End to Water Fluoridation

New York - February 24, 2008 -- In a statement first released August
9, 2007, almost 2,000 professionals urge Congress to stop water
fluoridation until Congressional hearings are conducted. They cite new
scientific evidence that fluoridation, long promoted to fight tooth
decay, is ineffective and has serious health risks. (http://
http://www.fluorideaction.org/statem...gust.2007.html)

Signers include a Nobel Prize winner, three members of the prestigious
2006 National Research Council (NRC) panel that reported on fluoride's
toxicology, two officers in the Union representing professionals at
EPA headquarters, the President of the International Society of
Doctors for the Environment, and hundreds of medical, dental,
academic, scientific and environmental professionals, worldwide.

Signer Dr. Arvid Carlsson, winner of the 2000 Nobel Prize for
Medicine, says, "Fluoridation is against all principles of modern
pharmacology. It's really obsolete."

An Online Action Petition to Congress in support of the Professionals'
Statement is available on FAN's web site, www.fluorideaction.org/congress
..

"The NRC report dramatically changed scientific understanding of
fluoride's health risks," says Paul Connett, PhD, Executive Director,
Fluoride Action Network. "Government officials who continue to
promote fluoridation must testify under oath as to why they are
ignoring the powerful evidence of harm in the NRC report," he added.

An Assistant NY State Attorney General calls the report "the most up-
to-date expert authority on the health effects of fluoride exposure."

The Professionals' Statement also references:

-- The new American Dental Association policy recommending infant
formula NOT be prepared with fluoridated water.
-- The CDC's concession that the predominant benefit of fluoride is
topical not systemic.
-- CDC data showing that dental fluorosis, caused by fluoride over-
exposure, now impacts one third of American children.
-- Major research indicating little difference in decay rates between
fluoridated and non-fluoridated communities.
-- A Harvard study indicating a possible link between fluoridation and
bone cancer.
-- The silicofluoride chemicals used for fluoridation are contaminated
industrial waste and have never been FDA- approved for human
ingestion.

The Environmental Working Group (EWG), a DC watchdog, revealed that a
Harvard professor concealed the fluoridation/bone cancer connection
for three years. EWG President Ken Cook states, "It is time for the US
to recognize that fluoridation has serious risks that far outweigh any
minor benefits, and unlike many other environmental issues, it's as
easy to end as turning off a valve at the water plant."

Further, researchers reporting in the Oct 6 2007 British Medical
Journal indicate that fluoridation, touted as a safe cavity
preventive, never was proven safe or effective and may be unethical.
(1)

Partially, as a result of the professionals' statement, at least one
city, Cobleskill NY, stopped 54 years of water fluoridation. See:
http://www.fluoridealert.org/news/2998.html

In New York State, the Central Bridge Water District stopped
fluoridation in 2006, Homer in 2005, Canton in 2003. Oneida rejected
fluoridation in 2002. Ithaca rejected fluoridation in 2002. Johnstown
rejected it in 1999. Before that several towns in Nassau County
stopped fluoridation. Suffolk County rejected fluoridation in the
1990's.

Many communities rejected or stopped fluoridation over the years. See:
http://www.fluoridealert.org/communities.htm

On October 2, Juneau Alaska voters rejected fluoridation despite the
American Dental Association's $150,000 political campaign to return
fluoride into the water supply after the legislative body voted it
out.


References:

(1) "Adding fluoride to water supplies," British Medical Journal, KK
Cheng, Iain Chalmers, Trevor A. Sheldon, October 6, 2007


  #2  
Old February 24th 08, 07:10 PM posted to misc.kids.breastfeeding,misc.kids.health,sci.med.nutrition,talk.environment,misc.kids.pregnancy
jay
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Posts: 44
Default Dentists Oppose Fluoridation; You Should Too

Professionals Urge End to Water Fluoridation

Fluoride damages the mitochondira, the compartment within cells that
converts food into useable energy. Below article indicates fluoride
damages the oral gum cells' mito.


Involvement of both mitochondrial- and death receptor-dependent
apoptotic pathways regulated by Bcl-2 family in sodium fluoride-
induced apoptosis of the human gingival fibroblasts.

Sodium fluoride (NaF) has been shown to be cytotoxic and produces
inflammatory responses in humans. However, the cellular mechanisms
underlying the NaF-induced cytotoxicity in periodontal tissues are
unclear. This study examined whether or not NaF induces apoptosis in
human gingival fibroblasts (HGF), and its underlying mechanisms by
monitoring various apoptosis-associated processes. NaF reduced the
cell viability of HGF in a dose- and time-dependent manner. NaF
increased TUNEL-positive cell and induced apoptosis with concomitant
chromatin condensation and DNA fragmentation in HGF. In addition, NaF
increased the level of cytochrome c released from the mitochondria
into the cytosol, enhanced the caspase-9, -8 and -3 activities, the
cleavage of poly (ADP-ribose) polymerase (PARP), and up-regulated the
voltage-dependent anion channel (VDAC) 1. However, NaF did not affect
the production of reactive oxygen species (ROS) which is a strong
apoptotic inducer. Furthermore, NaF up-regulated the Fas-ligand (Fas-
L), a ligand of death receptor. Bcl-2, a member of the anti-apoptotic
Bcl-2 family, was down-regulated, whereas the expression of Bax, a
member of the pro-apoptotic Bcl-2 family, was unaffected in the NaF-
treated HGF. These results suggest that NaF induces apoptosis in HGF
through both the mitochondria-mediated pathways regulated by the Bcl-2
family and death receptor-mediated pathway. PMID: 18069112
  #3  
Old February 24th 08, 07:15 PM posted to misc.kids.breastfeeding,misc.kids.health,sci.med.nutrition,talk.environment,misc.kids.pregnancy
jay
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Posts: 44
Default Dentists Oppose Fluoridation; You Should Too

Professionals Urge End to Water Fluoridation

Below abstract indicates the mito of cells that create tooth enamel
are damaged by fluoride.

Ultrastructural morphometric analysis of ameloblasts exposed to
fluoride during tooth development.

Since a considerable amount of the world population is exposed to high
doses of fluoride, it is of special concern to investigate its action
mechanisms during dental enamel development. In this study, the
toxicity of fluoride in ameloblasts during enamel development was
evaluated by means of ultrastructural morphometric analysis. A total
of 18 male Wistar rats were distributed into three groups. In Group I,
the animals received deionized drinking water ad libitum (negative
control) and in Groups II and III, they received sodium fluorided
(NaF) drinking water at doses of 7 and 100 ppm ad libitum,
respectively, for 6 weeks. Morphometric data were expressed as volume
density of the most significant organelles present in the secretory
and maturation phases of amelogenesis such as RER, granules,
lysosomes, phagic vacuoles, microfilaments and mitochondria. The
results showed that the volume density of mitochondria in the 100 ppm
experimental group was 29% (P 0.05) higher than the control group in
secretory ameloblasts. No remarkable differences were found in
maturation ameloblasts for all organelles evaluated. Taken together,
these data indicate that NaF at high doses is able to induce cellular
damage in secretory ameloblasts, whereas no noxious effect was
observed during maturation stage of amelogenesis as depicted by
ultrastructural analysis. PMID: 17077986
  #4  
Old February 24th 08, 07:20 PM posted to misc.kids.breastfeeding,misc.kids.health,sci.med.nutrition,talk.environment,misc.kids.pregnancy
jay
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Posts: 44
Default Dentists Oppose Fluoridation; You Should Too

Professionals Urge End to Water Fluoridation

Below abstract indicates fluoride damages mito of rat liver cells.

Effect of fluoride on activities of enzyme and ultrastructure in
primary cultured rat hepatocytes

OBJECTIVE: To study the cell viability, activities of enzyme and
ultrastructure changes induced by sodium fluoride in primary cultured
rat hepatocytes. METHODS: Hepatocytes were isolated using half-in situ
collagenase digestion method. Cellular viability was determined by MTT
method. The activities of ALT and AST were determined by
spectrophotography method. The ultrastructure changes of hepatocyte
were observed under transmission electron microscope. RESULTS: After
cultured with various concentrations of fluoride for 24 hours, a dose-
dependent decrease of cell viability was detected in the hepatocytes.
The activities of AST and ALT in the 2 mmol/L and 4 mmol/L groups were
significantly higher than the control group (P 0.05). Transmission
electron microscope study showed that in fluoride treated hepatocytes
the changes included swollen mitochondria and disordered, disrupted
endoplasm reticulum. CONCLUSION: Excessive fluoride induced
significant toxicity in primary cultured hepatocytes which manifested
the injuries of membrane and organell plasma membrane. PMID: 15862017
  #5  
Old February 24th 08, 07:23 PM posted to misc.kids.breastfeeding,misc.kids.health,sci.med.nutrition,talk.environment,misc.kids.pregnancy
jay
external usenet poster
 
Posts: 44
Default Dentists Oppose Fluoridation; You Should Too

Professionals Urge End to Water Fluoridation

Below abstract indicates fluoride damages mito of rat liver and
pancreas cells.

Ultrastructural study of the mitochondria in the submandibular gland,
the pancreas and the liver of young rats, exposed to NaF in drinking
water.

The aim of the experiment was to determine the effect of fluoride on
ultrastructural changes in the submandibular gland, the pancreas and
the liver. The experimental rats received fluoride in aqueous
solutions of sodium fluoride at concentrations of 10.6 NaF/dm3 and
32.0 NaF/dm3. In the ultrastructural examination, mitochondria were
most damaged. PMID: 15638415
  #6  
Old February 24th 08, 07:27 PM posted to misc.kids.breastfeeding,misc.kids.health,sci.med.nutrition,talk.environment,misc.kids.pregnancy
jay
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Posts: 44
Default Dentists Oppose Fluoridation; You Should Too

Professionals Urge End to Water Fluoridation

Below abstract indicates that fluoride derivates can be used to damage
mito thus cause cell death.

Fluoride curcumin derivatives: new mitochondrial uncoupling agents.

The mitochondrial effects of two fluoride curcumin derivatives were
studied. They induced the collapse of mitochondrial membrane potential
(DeltaPsi), increased mitochondrial respiration, and decreased O(2)*-
production and promoted Ca(2+) release. These effects were reversed by
the recoupling agent 6-Ketocholestanol, but not by cyclosporin A, an
inhibitor of the permeability transition pore (PTP), suggesting that
these compounds act as uncoupling agents. This idea was reinforced by
the analysis of the physico-chemical properties of the compounds
indicating, that they are mainly in the anionic form in the
mitochondrial membrane. Moreover, they are able to induce PTP opening
by promoting the oxidation of thiol groups and the release of
cytochrome c, making these two molecules potential candidates for
induction of apoptosis. PMID: 15225605
  #7  
Old February 24th 08, 07:32 PM posted to misc.kids.breastfeeding,misc.kids.health,sci.med.nutrition,talk.environment,misc.kids.pregnancy
jay
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Posts: 44
Default Dentists Oppose Fluoridation; You Should Too

Professionals Urge End to Water Fluoridation

Below abstract indicates fluoride fed animals performed poorly in
performance tests due to mito damage in brain cells.

Neurotoxicity of fluoride: neurodegeneration in hippocampus of female
mice.

Light microscopic study of hippocampal sub-regions demonstrated
significant number of degenerated nerve cell bodies in the CA3, CA4
and dentate gyrus(Dg) areas of sodium fluoride administered adult
female mice. Ultrastructural studies revealed neurodegenrative
characteristics like involution of cell membranes, swelling of
mitochondria, clumping of chromatin material etc, can be observed in
cell bodies of CA3, CA4 and dentate gyrus (Dg). Fluoride intoxicated
animals also performed poorly in motor co-ordination tests and maze
tests. Inability to perform well increased with higher fluoride
concentration in drinking water. PMID: 12622200
  #8  
Old February 24th 08, 07:36 PM posted to misc.kids.breastfeeding,misc.kids.health,sci.med.nutrition,talk.environment,misc.kids.pregnancy
jay
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Posts: 44
Default Dentists Oppose Fluoridation; You Should Too

Professionals Urge End to Water Fluoridation

Below abstract indicates fluoride derivates damage mito in rabbit
kidney cells.

Fluoride ion toxicity in rabbit kidney thick ascending limb cells.

BACKGROUND AND OBJECTIVE: Some halogenated agents, especially
methoxyflurane, because of a higher level of fluoride production,
induce a renal concentrating defect that could be related to an
ascending limb impairment. We investigated the mechanisms of fluoride
toxicity on an immortalized cell line. METHODS: Cells were cultured
for 2, 6 or 24 h in the presence of fluoride. Toxicity evaluation was
based on: cell numbers, protein content, leucine-incorporation,
lactate dehydrogenase (LDH) and N-acetyl-beta-glucosaminidase (NAG)
releases, Na-K-ATPase and Na-K-2Cl activities, electron microscope
studies. Infrared analysis and fluoride microdetermination allowed
crystal components. RESULTS: At 5 mmol after 24 h, fluoride decreased
cell numbers (-14%, *P 0.05), protein content (-16%*), leucine
incorporation (-54%*), Na-K-2Cl activity (-84%*), increased LDH
(+145%*) and NAG release (+190%*). Na-K-ATPase was more sensitive and
impaired from 1 mmol for 24h and after 2 h at 5 mmol. Crystal
formation in mitochondria occurred after 6 h at 5 mmol. Infra-red
analysis and fluoride microdetermination established that crystals
contained sodium, phosphate and fluoride. CONCLUSIONS: The results
suggest that the Na-K-ATPase pump is a major target for fluoride
toxicity in Henle's loop. PMID: 12095014
  #9  
Old February 24th 08, 07:38 PM posted to misc.kids.breastfeeding,misc.kids.health,sci.med.nutrition,talk.environment,misc.kids.pregnancy
jay
external usenet poster
 
Posts: 44
Default Dentists Oppose Fluoridation; You Should Too

Professionals Urge End to Water Fluoridation

Below abstract indicates fluoride damages of mito of human tooth pulp
cells.

Cytotoxicity of fluoride on human pulp cell cultures in vitro.

OBJECTIVES: Numerous studies have revealed that conventional glass-
ionomer cements might release fluoride into an aqueous environment.
The objective of this study was to examine the effects of fluoride on
human pulp cells in vitro. STUDY DESIGN: H33258 fluorescence, cell
proliferation, protein synthesis, and mitochondrial activity assay
were used to investigate the pathobiological effects of fluoride on
cultured human pulp cells. RESULTS: Fluoride was found to be a
cytotoxic agent to cultured human pulp cells by inhibiting cell
growth, proliferation, mitochondrial activity, and protein synthesis.
CONCLUSIONS: Fluoride release has significant potential for pulpal
toxicity. PMID: 11174602
  #10  
Old February 24th 08, 07:42 PM posted to misc.kids.breastfeeding,misc.kids.health,sci.med.nutrition,talk.environment,misc.kids.pregnancy
jay
external usenet poster
 
Posts: 44
Default Dentists Oppose Fluoridation; You Should Too

Professionals Urge End to Water Fluoridation

Below abstract indicates fluoride derivative inhibits mito function in
cows.

Structure of bovine mitochondrial F(1)-ATPase inhibited by Mg(2+) ADP
and aluminium fluoride.

BACKGROUND: The globular domain of the membrane-associated F(1)F(o)-
ATP synthase complex can be detached intact as a water-soluble
fragment known as F(1)-ATPase. It consists of five different subunits,
alpha, beta, gamma, delta and epsilon, assembled with the
stoichiometry 3:3:1:1:1. In the crystal structure of bovine F(1)-
ATPase determined previously at 2.8 A resolution, the three catalytic
beta subunits and the three noncatalytic alpha subunits are arranged
alternately around a central alpha-helical coiled coil in the gamma
subunit. In the crystals, the catalytic sites have different
nucleotide occupancies. One contains the triphosphate form of the
nucleotide, the second contains the diphosphate, and the third is
unoccupied. Fluoroaluminate complexes have been shown to mimic the
transition state in several ATP and GTP hydrolases. In order to
understand more about its catalytic mechanism, F(1)-ATPase was
inhibited with Mg(2+)ADP and aluminium fluoride and the structure of
the inhibited complex was determined by X-ray crystallography.
RESULTS: The structure of bovine F(1)-ATPase inhibited with Mg(2+)ADP
and aluminium fluoride determined at 2.5 A resolution differs little
from the original structure with bound AMP-PNP and ADP. The nucleotide
occupancies of the alpha and beta subunits are unchanged except that
both aluminium trifluoride and Mg(2+)ADP are bound in the nucleotide-
binding site of the beta(DP) subunit. The presence of aluminium
fluoride is accompanied by only minor adjustments in the surrounding
protein. CONCLUSIONS: The structure appears to mimic a possible
transition state. The coordination of the aluminofluoride group has
many features in common with other aluminofluoride-NTP hydrolase
complexes. Apparently, once nucleotide is bound to the catalytic beta
subunit, no additional major structural changes are required for
catalysis to occur. PMID: 10873854
 




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