A Parenting & kids forum. ParentingBanter.com

If this is your first visit, be sure to check out the FAQ by clicking the link above. You may have to register before you can post: click the register link above to proceed. To start viewing messages, select the forum that you want to visit from the selection below.

Go Back   Home » ParentingBanter.com forum » misc.kids » Kids Health
Site Map Home Authors List Search Today's Posts Mark Forums Read Web Partners

NEJM: Loss of Vaccine-Induced Immunity to Varicella over Time



 
 
Thread Tools Display Modes
  #1  
Old March 15th 07, 03:15 PM posted to misc.kids.health
Jeff
external usenet poster
 
Posts: 368
Default NEJM: Loss of Vaccine-Induced Immunity to Varicella over Time

From the March 15, 2007 issue of the New England Journal of Medicine.

Loss of Vaccine-Induced Immunity to Varicella over Time
Sandra S. Chaves, M.D., M.Sc., Paul Gargiullo, Ph.D., John X. Zhang, Ph.D.,
Rachel Civen, M.D., Dalya Guris, M.D., M.P.H., Laurene Mascola, M.D.,
M.P.H., and Jane F. Seward, M.B., B.S., M.P.H.

Background The introduction of universal varicella vaccination in 1995 has
substantially reduced varicella-related morbidity and mortality in the
United States. However, it remains unclear whether vaccine-induced immunity
wanes over time, a condition that may result in increased susceptibility
later in life, when the risk of serious complications may be greater than in
childhood.

Methods We examined 10 years (1995 to 2004) of active surveillance data from
a sentinel population of 350,000 subjects to determine whether the severity
and incidence of breakthrough varicella (with an onset of rash 42 days
after vaccination) increased with the time since vaccination. We used
multivariate logistic regression to adjust for the year of disease onset
(calendar year) and the subject's age at both disease onset and vaccination.

Results A total of 11,356 subjects were reported to have varicella during
the surveillance period, of whom 1080 (9.5%) had breakthrough disease.
Children between the ages of 8 and 12 years who had been vaccinated at least
5 years previously were significantly more likely to have moderate or severe
disease than were those who had been vaccinated less than 5 years previously
(risk ratio, 2.6; 95% confidence interval [CI], 1.2 to 5.8). The annual rate
of breakthrough varicella significantly increased with the time since
vaccination, from 1.6 cases per 1000 person-years (95% CI, 1.2 to 2.0)
within 1 year after vaccination to 9.0 per 1000 person-years (95% CI, 6.9 to
11.7) at 5 years and 58.2 per 1000 person-years (95% CI, 36.0 to 94.0) at 9
years.

Conclusions A second dose of varicella vaccine, now recommended for all
children, could improve protection from both primary vaccine failure and
waning vaccine-induced immunity.



 




Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Vaccines have been proven to cause insulin dependent diabetes and many are seeking compensation from the US government for this vaccine induced injury Jan Drew Kids Health 4 November 4th 06 05:29 AM
NEW B- The Case Against Universal Varicella Vaccination. Sheri Nakken RN, MA, Hahnemannian Homeopath Kids Health 10 October 20th 06 05:32 PM
New NEJM study on gestational diabetes Ericka Kammerer Pregnancy 4 June 13th 05 01:11 PM
Time to Eliminate the National Vaccine Injury Act? john Kids Health 0 December 27th 04 01:57 PM
Stroke after varicella vaccination john Kids Health 0 December 17th 04 09:00 AM


All times are GMT +1. The time now is 01:04 PM.


Powered by vBulletin® Version 3.6.4
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Copyright ©2004-2024 ParentingBanter.com.
The comments are property of their posters.