Thimerosal More Toxic then Methylmercury!!

Methyl-mercury, usually from contaminated food, is very dangerous to
pregnant women. Methyl-mercury causes profound mental retardation,
cerebral palsy, seizures, spasticity, tremors, and incoordination, along
with eye and hearing damage in the unborn baby as a result of the
mother's exposure. Organic mercury passes into the breast milk as well.


The effect of thimerosal, an organomercurial preservative in vaccines, on
cerebellar neurons dissociated from 2-week-old rats was compared with
those of methylmercury using a flow cytometer with appropriate
fluorescent dyes. Thimerosal and methylmercury at concentrations ranging
from 0.3 to 10 microM increased the intracellular concentration of Ca2+
([Ca2+]i) in a concentration- dependent manner. The potency of 10 microM
thimerosal to increase the [Ca2+]i was less than that of 10 microM
methylmercury. Their effects on the [Ca2+]i were greatly attenuated, but
not completely suppressed, under external Ca(2+)-free condition,
suggesting a possibility that both agents increase membrane Ca2+
permeability and release Ca2+ from intracellular calcium stores. The
effect of 10 microM thimerosal was not affected by simultaneous
application of 30 microM L-cysteine whereas that of 10 microM
methylmercury was significantly suppressed. The potency of thimerosal
was similar to that of methylmercury in the presence of L-cysteine. Both
agents at 1 microM or more similarly decreased the cellular content of
glutathione in a concentration-dependent manner, suggesting an increase
in oxidative stress. Results indicate that thimerosal exerts some
cytotoxic actions on cerebellar granule neurons dissociated from
2-week-old rats and its potency is almost similar



thimerosal is only 1/2 mercury (ethylmercury), so the authors should have
compared 1/2 dose thimerosal with 1 dose methylmercury. The conclusion
would then be that ethylmercury is equally potent to methylmercury in
increasing Ca2++. The study also says that unlike methylmercury (which is
usually bound to cysteine in a cell) thimerosal's potency is unaffected by
presence of L-cysteine in the neuron, so under in vivo conditions the
effects of ethylmercury are likely greater (by a factor or 2) than methyl.
Finally, the study shows that thimerosal is more potent than methyl in
decreasing glutathione levels in the cell, which is what other researchers
have/are finding as well.

This study was dont last year.

This is misleading because thimerasol is not pumping in the brain like
methylmercury is and thimerasol is removed from the brain more rapidly.

Jeff

This is misleading because thimerasol is not pumping in the brain like
methylmercury is and thimerasol is removed from the brain more rapidly.

Jeff



*******************************************

Thimerosal inhibits Folate DNA Methylation;

Department of Pharmaceutical Sciences, Northeastern Unviersity Boston.
Dr Richard Deth

http://www.nupr.neu.edu/2-04/deth_article.pdf
__________________________________________________ ______________________

Newest study on thimerosal funded through the NIH.

Dr. Burbacher's study shows that twice as much mercury remains trapped in
the brain from doses of ethylmercury in thimerosal compared to equal doses
of
methylmercury.



Here is the direct link to the NIH study...

http://ehp.niehs.nih.gov/members/2005/7712/7712.pdf



Page 17:

"There was a much HIGHER proportion of inorganic mercury in
the brain of thimerosal than methylmercury infants (up to 71% vs
10%)"


Donna

"Kevysmom" wrote in message
lkaboutparenting.com...
This is misleading because thimerasol is not pumping in the brain like
methylmercury is and thimerasol is removed from the brain more rapidly.

Jeff



*******************************************

Thimerosal inhibits Folate DNA Methylation;

Department of Pharmaceutical Sciences, Northeastern Unviersity Boston.
Dr Richard Deth

http://www.nupr.neu.edu/2-04/deth_article.pdf
__________________________________________________ ______________________

Newest study on thimerosal funded through the NIH.

Dr. Burbacher's study shows that twice as much mercury remains trapped in
the brain from doses of ethylmercury in thimerosal compared to equal doses
of
methylmercury.



Here is the direct link to the NIH study...

http://ehp.niehs.nih.gov/members/2005/7712/7712.pdf



Page 17:

"There was a much HIGHER proportion of inorganic mercury in
the brain of thimerosal than methylmercury infants (up to 71% vs
10%)"


Donna

We have been through this before. The reason why there is more inorganic
mercury is that the body detoxifies organic mercury by turning it into
inorganic mercury. This happens faster for ethylmercury than methylmercury
(see the graphs in the paper above).

The following paragraphs states: "Previous reports have indicated that the
dealkylation of mercury is a detoxification process that helps to protect
the CNS (Magos et al. 1985; Magos 2003). These reports are largely based on
histology and histochemistry studies of adult rodents exposed to mercury for
a short period of time. The results of these studies indicated damage to the
cerebellum was only observed in MeHg treated animals who had much lower
levels of inorganic mercury in the brain than animals comparably treated
with ethylmercury. Moreover, the results did not indicate the presence of
inorganic mercury deposits in the area where the cerebellar damage was
localized (granular layer)."

This indicates that ethylmercury is less toxic than methylmercury, because
it is detoxified faster.

Jeff

This indicates that ethylmercury is less toxic than methylmercury, because

it is detoxified faster.

Jeff

***************************

Its LESS toxic, Doesnt mean its NOT Toxic!

Donna

This indicates that ethylmercury is less toxic than methylmercury, because

it is detoxified faster.

Jeff

***************************

Its LESS toxic, Doesnt mean its NOT Toxic!

Donna

**********************

In section 2.b.a Dr. Magos quotes his research as showing that
methylmercury treated rats had 1.55 (males) and 2.4 (females) the mercury
in their brains as did ethyl mercury treated rats. In addition, the ethyl
mercury treated rats had 3.4 fold more inorganic mercury in their brains.
He states that this "excludes the possibility that the cleavage itself or
the formed inorganic mercury is responsible for the brain damage. If this
were the case, the brain ethyl mercury treated rats would be more affected
than the brain of methylmercury treated rats (which didn't occur by his
analysis)." The problem with this conclusion is that Dr. Magos expects the
damage caused by methylmercury to be the same as that caused by a
combination of ethyl mercury and 3.4 fold extra Hg2+. This is not likely
as methyl and ethyl mercury would partition into the hydrophobic areas of
the brain whereas Hg2+ would most likely react in the hydrophilic aspect
of the brain. The inhibition of specific brain enzymes by thimerosal
(ethyl mercury) compared to Hg2+ are markedly different.

http://64.41.99.118/vran/vaccines/mercury/mer_haley.htm

Donna

Kevysmom wrote:
This indicates that ethylmercury is less toxic than methylmercury, because

it is detoxified faster.

Jeff

***************************

Its LESS toxic, Doesnt mean its NOT Toxic!

When you discuss toxicity you must consider both the dose, clearnace and
the toxicity of the chemical.

Thus, ethyl mercury, like that found in thimerosal, is safter than that
of methylmercury. They do not equate.

Kevysmom wrote:
This indicates that ethylmercury is less toxic than methylmercury, because

it is detoxified faster.

Jeff

***************************

Its LESS toxic, Doesnt mean its NOT Toxic!

Donna

**********************

In section 2.b.a Dr. Magos quotes his research as showing that
methylmercury treated rats had 1.55 (males) and 2.4 (females) the mercury
in their brains as did ethyl mercury treated rats. In addition, the ethyl
mercury treated rats had 3.4 fold more inorganic mercury in their brains.
He states that this "excludes the possibility that the cleavage itself or
the formed inorganic mercury is responsible for the brain damage. If this
were the case, the brain ethyl mercury treated rats would be more affected
than the brain of methylmercury treated rats (which didn't occur by his
analysis)." The problem with this conclusion is that Dr. Magos expects the
damage caused by methylmercury to be the same as that caused by a
combination of ethyl mercury and 3.4 fold extra Hg2+. This is not likely
as methyl and ethyl mercury would partition into the hydrophobic areas of
the brain whereas Hg2+ would most likely react in the hydrophilic aspect
of the brain. The inhibition of specific brain enzymes by thimerosal
(ethyl mercury) compared to Hg2+ are markedly different.

http://64.41.99.118/vran/vaccines/mercury/mer_haley.htm

Quoting Boyd Haley who is abusive to autistics and a proven bull****ter
will not make you points with anyone who knows him.

Haley, for instance, bleats and brays the claim that thimerisol is 50%
mercury. While the one mercury atom does comprise approximately 50% of
the molecular weight of thimerosal, this is a meaningless claim, as it
has no bearing whatsoever on the chemiczal activity of any part of the
molecule.

My 16 year old son who is running a straight B average in high school
chemistry pointed this out to me when I asked him to find a flaw in
Haley's bull****.

Now, if Haley is so inept as to make such a bogus claim on something
that is so fundamental that it is taught in high school, what does that
tell you about him?

It tells me that he is a bull****ter.