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#1
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Hales lookup please!
Could someone with a copy of Hale's please tell me if Advair (for asthma) is
safe while breastfeeding. My doctor is of no help at all. He's never heard of Dr. Hale (@@) and thinks the only tool of reference is the PDA! UGH! Thanks! -- Amy~ Tre' (6/92) Keelyn (6/95) Peyton (10/00) Halli (8/15/03) |
#2
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Hales lookup please!
Amy M. wrote:
Could someone with a copy of Hale's please tell me if Advair (for asthma) is safe while breastfeeding. http://www.google.com/groups?q=fluti...tfeeding &hl= en&lr=&ie=UTF-8&oe=UTF-8&scoring=d&selm=gbidnVBcGJBrKf6iU-KYuQ%40comcast.com &rnum=1 Advair is fluticasone and salmeterol. Fluticasone is an L3. "When instilled intranasally, the absolute bioavailability is less than 2%, so vitrually none of the dose instilled in absorbed systemically. Oral absorption following inhaled fluticasone is approximately 30%, although amlmost instant first-pass absorption virtually eliminates plasma levels of fluticasone." "With the above oral and systemic bioavailability, and rapid first-pass uptake by the liver, it is not liekly that milk levels will be clinically relevant, even with rather high doses." Salmeterol is an L2. "Maternal plasma levels of salmeterol after inhaled administration are very low or undetectable." No reports of use in lactating women are available, though, so I would guess that's a large part of the reasoning behind the big old CYA on the insert. -- iphigenia www.tristyn.net "i have heard the mermaids singing, each to each. i do not think that they will sing to me." |
#3
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Hales lookup please!
Thanks so much!
-- Amy~ Tre' (6/92) Keelyn (6/95) Peyton (10/00) Halli (8/15/03) |
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