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Merck Mouth, Myrl Jeffcoat, claims Gardasil can "Return them to Health" ... FALSE FALSE FALSE FALSE FALSE FALSE FALSE
(Myrl Jeffcoat as Will Ketcher from the archives she loves to talk
about.) From: Will Ketcher - aka Myrl Carlene Jeffcoat ... donning her jockstrap to flirt with Willa Nidiffer ... aka Cathy Credulous aka Nanaweedkiller ... another snake-oil vigilante. http://www.BreastImplantAwareness.or...Willa-Nidiffer Date: Wed, Nov 19 2003 2:07 am Email: (Will Ketcher) Groups: alt.support.breast-implant Ms Weedkiller--I think you are the most cool thing present on this board. I am turned on by your delightful presence--If you should ever become a widow -- or available for companionship -- I would love to be your gentleman. You are a most special person. I say that with the most respectful admiration. Your Admirer-- Will Ketcher ~~~~~~~~~~~~~ Myrl Jeffcoat as Myrl Jeffcoat from the archives she loves to talk about ... "I must admit however, I am a Rev. Cathy Credulous "wannabe," and wouldbe happy to call "her" work my own!" Myrl Carlene Jeffcoat, September 1, 2001 NANA. . .That is toooooo funny for words. I'm on the floor laughing! Thanks for being precious you! Myrl Carlene Jeffcoat, October 18, 2003 What is 1000% fact is that Willa Nidiffer aka Cathy Credulous aka Nanaweedkiller works directly promoting quackwatch and the healthfrauds. http://www.BreastImplantAwareness.or...weedkiller.htm |
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Merck Mouth, Myrl Jeffcoat, claims Gardasil can "Return them to Health" ... FALSE FALSE FALSE FALSE FALSE FALSE FALSE
Myrl Jeffcoat, in one of her dozens of rants and raves a while back,,
in her idiocy, claimed: What Ilena Rosenthal wants is FREE SPEECH for herself, while curtailing it for most everyone else. Jeffcoat, ever since you began advertising the quackery of Barrett you have shown yourself to be a stalker, a liar, and absolutely absurd. You donned a jockstrap, called yourself "Will Ketcher" and harassed and attacked me, while promoting Quackwatch and the 3 losers suing me in court. You highjacked my personal name, have cybersquattered a website of my personal name, and have spent 7 years of your life attempting to make people believe I am who you wish I was. Here is who I am: www.BreastImplantAwareness.org/ http://ilenarose.blogspot.com http://ilena-rosenthal.blogspot.com http://breastimplantawareness.blogspot.com http://www.BreastImplantAwareness.or...sRosenthal.htm I am Rosenthal who defeated Stephen Barrett in 3 courts You shill for Gardasil and post vaccination lies in general ... backing some of the wealthiest corporations in the world, and whine and scream and rant and lie voraciously about our small non profit. For you to make such a ridiculous and idiotic claim that about "what I want" shows your deep desperation ... already showing for several years now. You are far, far, far stupider than I thought ... and you underestimate what I will do to defend myself against your perfidy. God help you, you fool. www.BreastImplantAwareness.org/myrl.html Thousands and thousands of posts ... under various aliases as well as her own ... is she curtailed or lying again???? |
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Merck Mouth, Myrl Jeffcoat, claims Gardasil can "Return them to Health" ... FALSE FALSE FALSE FALSE FALSE FALSE FALSE
From: Myrl - view profile
Date: Tues, Oct 3 2006 11:33 pm Email: "Myrl" Groups: alt.support.breast-implant, talk.politics.medicine So it all begs the question. . .Did the silicone manufacturer PR machine have such deep pockets, that Ilena Rosenthal joined her hips with BMS attorney, Nate Schachtman, in Judge Pointer's courtroom, hoping to pick one of Nate's deep pockets? ~~~~~~~~~~~~ Date: Wed, Oct 4 2006 7:50 am Email: Ilena Rose Groups: alt.support.breast-implant, talk.politics.medicine LMVVVVSweeet AO ... Yes Myrl, in your frustrated sexual, perverted fantasies, for your own entertainment and libelous rantings, .... please delude yourself into imagining Nathan Schachtman and I, in Judge Pointer's open Courtroom in Birmingham, with Sally Kirkland and Barb Hulka and about 100 other people all watching and clapping ... ....thrashing around and panting like barnyard pigs, joining our piggy hips together, and porking our brains out Much of the last 7 years have been spent on Usenet defending myself against Myrl's sexual fantasies about me ... such a twisted shill is Myrl. She appears to need to have these sexual imagest in order to keep her attacks on me going ... many believe her jealousy of me is uncontrollable ... and Barrett & O'leary offered her a job to play them out by using her to attack me. www.BreastImplantAwareness.org/myrl.html Read more of Myrl's deluded fantasies ... |
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Merck Mouth, Myrl Jeffcoat, claims Gardasil can "Return them to Health" ... FALSE FALSE FALSE FALSE FALSE FALSE FALSE
From: Myrl - view profile
Date: Tues, Oct 3 2006 11:33 pm Email: "Myrl" Groups: alt.support.breast-implant, talk.politics.medicine So it all begs the question. . .Did the silicone manufacturer PR machine have such deep pockets, that Ilena Rosenthal joined her hips with BMS attorney, Nate Schachtman, in Judge Pointer's courtroom, hoping to pick one of Nate's deep pockets? ~~~~~~~~~~~~ Date: Wed, Oct 4 2006 7:50 am Email: Ilena Rose Groups: alt.support.breast-implant, talk.politics.medicine LMVVVVSweeet AO ... Yes Myrl, in your frustrated sexual, perverted fantasies, for your own entertainment and libelous rantings, .... please delude yourself into imagining Nathan Schachtman and I, in Judge Pointer's open Courtroom in Birmingham, with Sally Kirkland and Barb Hulka and about 100 other people all watching and clapping ... ....thrashing around and panting like barnyard pigs, joining our piggy hips together, and porking our brains out Much of the last 7 years have been spent on Usenet defending myself against Myrl's sexual fantasies about me ... such a twisted shill is Myrl. She appears to need to have these sexual imagest in order to keep her attacks on me going ... many believe her jealousy of me is uncontrollable ... and Barrett & O'leary offered her a job to play them out by using her to attack me. www.BreastImplantAwareness.org/myrl.html Read more of Myrl's deluded fantasies ... |
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Merck Mouth, Myrl Jeffcoat, claims Gardasil can "Return them to Health" ... FALSE FALSE FALSE FALSE FALSE FALSE FALSE
Myrl ... you lying old woman.
Dr. Zaffuto is a wonderful man ... and your projections from your dirty, haggard old filthy mind are all about you. He has done more to help women harmed by breast implants than you will do in your life. You and your quack friends and Coleah have attacked this loving man for years ... stolen a copywritten photo for your attack site ... and filled his mailbox with your lies and assaults. www.BreastImplantAwareness.org/snake-oil.htm http://www.BreastImplantAwareness.or...WatchWatch.htm Like your teammates from the Quackfilled Snake-oil Vigilatne Hatemongers ... your job is to destroy, just like twisted Barrett has done for years ... he's made fortunes harming people doing far more good than he will ever do. http://humanticsfoundation.com/dr_zaffuto.htm |
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Merck Mouth, Myrl Jeffcoat, claims Gardasil can "Return them to Health" ... FALSE FALSE FALSE FALSE FALSE FALSE FALSE
By Health Lover, Ilena Rosenthal
http://ilenarose.blogspot.com First published in the San Diego Business Journal, 1998 ... still true today www.BreastImplantAwareness.org/Smokescreen.htm http://ilena-rosenthal.blogspot.com The Silicone Smokescreen The purpose of law is to prevent the strong from always having their way. ~~Ovid, 43 BC -- 18 AD Ovid must be spinning in his grave! For 35 years, silicone manufacturers have been selling harmful breast implants -- products the FDA never approved. (update: in November, 2006, after 40 years, the FDA caved in to industry demands and gave 'safety approval' with many unenforceable conditions to Inamed & Mentor for silicone breast implants. Dr. Sidney Wolfe said it best: The approval makes a mockery of the legal standard that requires “reasonable assurance of safety.”) Following in the footsteps of their cousins --The Tobacco Barons -- the mighty Dows and other silicone manufacturers have run roughshod over the*legal system. They followed the winning formula: Bury all incriminating evidence. Deny its existence. Make the victims prove your product is not safe. Even then, deny it. Put profit over human life. Deny it. Create an incestuous relationship with the AMA and the FDA. Deny it. Hire expensive PR firms to sway public opinion. Purchase favorable media with mega-advertising dollars. Deny it. Sell sex. Above all, create a "smokescreen" to confuse and confound the issue and protect your bottom line. Repeatedly claim that "there is no scientific proof that smoking (or silicone) causes" disease." It's easy. Human beings make lousy lab rats. Tobacco has honed this formula beautifully for well over 50 profit-filled years. We've really "come a long way, baby." However, it wasn't until October 1996 (Science, October 18) after thousands of studies and tens of millions of smoking-related deaths, that medical science was able to identify a "missing link" between smoking and lung cancer. Finally, proof. By then was there any doubt? Already, a half a million Americans were dying annually from smoking related diseases. "Tobacco science" had proven what everyone has known for decades. Since the 60's, the silicone manufacturers, claiming no culpability, out of court and out of the public eye, s'ettled thousands of cases of implant problems with "gag" orders which kept their "dirty little secrets" hidden. When one brave woman, Mariann Hopkins, refused to be silenced and took her case to jury, former San Diegan Dan Bolton dropped a bombshell on the jury and produced vast amounts of damning evidence from Dow's own files. Included were concealed studies showing how for years, Dow Corning knew, denied and hid the serious dangers. Dow lost all appeals, and the Supreme Court eventually upheld the verdict of fraud. One of the studies that surfaced was the Dow sponsored, 1975 ACTA from Sweden which indicated that silicone crosses the placental barrier. As far reaching as this fact is, to date, physicians nationwide continue to assure implanted women that it is perfectly safe to carry and nurse babies. Not one OB/GYN can tell me on what scientific studies these assurances are based. None exists. Retired professor of Health Education, Henrietta Farber is appalled at the lack of information given women today as to the true risks of implants. A survivor of double mastectomies and a series of disastrous implant surgeries, she is shocked that Dr. Anne Wallace, UCSD Plastic Surgeon, still quotes small, manufacturer financed studies as "proof" of implant safety. "Similar studies, could not have shown any correlation between smoking and cancer. Dr. Wallace ignores newer studies indicating that 34% of post mastectomy patients required additional surgery within the first five years after implantation." Dr. Wallace, whose recent lecture aired on UCSD-TV, described saline implants as "bags of water," never mentioning the fungus, mold and bacterial infections known to flourish in these degradable silicone envelopes. Mrs. Farber added, "Over 33,000 women have filed complaints of serious complications to the FDA about their saline implants. People believe incorrectly that they have been approved by the FDA for safety." However, on KNSD-TV, "Dirty Doctor" Dean Edell, describes saline implants as "perfectly safe, perfectly fine." He has also been heard proclaiming that he hopes that "implanted women never get a penny" from the makers of their defective products. Oh yes, the pennies. Dow spent $191 million defending itself in the three years prior to declaring bankruptcy in 1992 and crashing the huge class action suit. Meanwhile, while safely in "bankruptcy protection" Dow Corning enjoyed profits of $61 million in 1996, while Papa Dow Chemical earned $452 million in the first quarter of 1997. Concurrently, here in San Diego County, there are estimated hundreds of women with no funds to have their disintegrating and ruptured implants removed. Many are too ill with multiple autoimmune diseases to care for themselves and their families. Brilliant as they were, The Dows made some early serious calculation errors as to "cost benefit." Using strategy modeled after the exploding Pinto gas tanks, as the numbers of ruptured implants surfaced, they hid the details and continued to claim falsified rupture figures of only 1-5%. Well-respected UCSD Radiologist, Dr. Michael Middleton, presented details of research done on 1,200 women to the Annual Meeting of the Radiological Society of North America in November, 1995. He explained that in these studies on women implanted between 10 and 12 years, "The rupture rate for non polyurethane-coated implants was 31%, compared to 91% for polyurethane-coated implants." The latter were taken off the market in 1991 after it was discovered that the polyurethane breaks down to TDA, a known carcinogen. I've heard of no women, however, who received a "recall notice." The infamous class action suits have been brilliant stalling devices to keep the money where the manufacturers want it. Mentor Corporation of Santa Barbara, threatening bankruptcy, forced all recipients to settle with a "take it or leave it" offer. Their 1996 earnings were $23.8 million. One of their customers, a 43 year old San Diegan woman who had had 3 sets of failed implants, Mentor¹s being one, has now reluctantly been forced into receiving public assistance. She has had 12 implant related surgeries, has accumulated over $120,000 in medical bills, and lives in constant pain. Her total settlement from Mentor -- $379.90. "It is unbelievable to me, that women dying, and those who will suffer agonizing pain for the remainder of their lives are barred from seeking legal recourse through our court system." For this reason, explains Joan Huffman, Executive Director of La Jolla based Research Update, they have sponsored Assembly Bill 1609, which recently received an affirmative vote from the Senate Judiciary Committee. "Women harmed by breast implants deserve access to the court system." "Silicone Science" like "Tobacco Science" can rage in controversy for decades. And just like tobacco, the evidence is the victims and their failed health. They know now what science may not figure out (or admit to) for years. With insurers such as Blue Cross/Blue Shield denying benefits to "women with a history of implants," this is a public health catastrophe in the making. And the tax payer, as always, will have to pick up the tab. May Ovid rest in peace. Ilena Rosenthal ©1997 |
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Merck Mouth, Myrl Jeffcoat, claims Gardasil can "Return them to Health" ... FALSE FALSE FALSE FALSE FALSE FALSE FALSE
Myrl has spent years running around Usenet and Yahoo groups trying to
distract from the core serious issues of the failing health of the women harmed by breast implants ... the perfect "insider" for her buddies at Quackwatch / NCAHF / snake-oil vigilante shills. www.BreastImplantAwareness.org/ www.BreastImplantInfo.org/ www.BreastImplantAwareness.org/Patty.html http://kathynyebreastimplants.homestead.com/ http://breastimplantawareness.blogspot.com www.BreastImplantAwareness.org/ http://www.implanttruth.jshood.com/links.html BRAVO to Julie! I've heard from several women in my support group who think this is one of the best exposes ever written to describe the plight of implanted women ... http://thenav.ca/index/news-app/stor...plant-industry Toxic Breasts: a peek inside the breast implant industry By Julie Chadwick November 22, 2006 Few aspects of the human anatomy have generated more hype, insecurity and fetishization than the female breast. It has been used to sell products; been the object of fame and obsession, and the cause of wishful thinking and embarrassment. It has been pushed, lifted, separated and prodded into every shape imaginable, as dictated by the fickle face of fashion. However, nothing has been quite as dangerous as the trend towards a surgically enhanced bust. The possibility of changing one’s “God-given” lot must have seemed like a miracle to certain hopeful young women when the prospect of breast implants first loomed in the early 1900s. These first experimentations were not actually implants but injections—first with paraffin, with disastrous results, and later with the patient’s own fat tissue, which was quickly reabsorbed and left scarring and unsightly lumps. Both methods were abandoned by the 1920’s and by the middle of the century, the body ideal was moving away from the svelte “flat” flapper and towards the curviness of the cheesecake pin-up. With this shift came more pressure on women to conform to the ideal, and subsequently created more desire for, and interest in, surgical options. Medical knowledge gained during World War II, coupled with technological advances with synthetics led surgeons to experiment with the insertion of spongy polyurethane derivatives with names like Surgifoam and Ivalon. These too, however, proved to be unsuccessful, as breast tissue filled in the holes and contracted around the sponge, often reducing it to a hard lump that was difficult to extricate. Inspired by Japanese prostitutes that were injecting silicone directly into their breasts in an attempt to attract American sailors, doctors in the US began to experiment with liquid silicone. Through the 50s and 60s, this practice became popular with topless dancers in Las Vegas and San Francisco. Its use became more widespread as, initially, it appeared to be a less-invasive procedure that any doctor could do. It is estimated that anywhere from at least 12,000 to 50,000 women received silicone injections during its period of popularity, which began to wane in the mid-60’s. It wasn’t long before complications associated with the injection of silicone began to set in. Some of the noted clear-cut effects were pain, skin discoloration, edema, ulceration and necrosis, calcification, granulomas, migration of the fluid, infection, cysts, axillary adenopathy, disfigurement and loss of the breast, liver granulomas and dysfunction, acute pneumonitis or adult respiratory distress syndrome, pulmonary embolism, coma, and death. As Frank Gerow and Thomas Cronin, two plastic surgeons from Texas, were developing the first silicone breast implant in 1961, there was already some dissent from within the ranks. On Jan. 24 of that same year, Ethel Mullison, the Staff Associate from the Dow Corning Center for Aid to Medical Research, sent a memo to Cronin. In the letter, she states that there are problems with silicone being “injected directly into the body,” and that “if enclosed within a silicone bag, the fluids would tend to diffuse out through the walls of the silicone rubber and be absorbed into the tissues.” This problem came to be known as ‘bleed’ - the tendency of silicone to ooze out of its protective shell (also made of silicone) and behave exactly like silicone injections - with all of the attendant complications. The first woman to receive silicone breast implants was Timmie Jean Lindsey, in 1962, and the following year Dow Corning began selling their Silastic brand of implants, without any long term testing or monitoring of their effects in humans. By 1976, the state of Nevada felt compelled to make the practice of injecting silicone a felony. Today, it is not approved by the FDA for any cosmetic use. As silicone made the journey from injections to implantations, many of the earlier problems and complications proved difficult to shake. Controversy over the safety of silicone dogged the breast augmentation industry every step of the way. The awareness of potential health threats associated with breast implants rocketed its way into the public consciousness when Dow Corning was hit with multiple lawsuits in the early 90’s. However, Dow had been quietly fighting complaints and court actions for a long time. In 1976, an amendment enacted by the FDA granted the Administration new power to regulate medical devices. However, it was a little too late for implants—they had already been on the market for a number of years, and as a result had been “grandfathered” into the system. The first court settlement was quietly awarded in 1977, to the tune of $170,000 (US). Another case against Dow Corning was subsequently won in 1984, for over $1.5 million (US), during which numerous internal company documents and memos were leaked. By 1988 the FDA jumped into action and recategorized breast implants as a high-risk product. They set a deadline for manufacturers to prove the safety of implants by July of 1991. By the time the deadline arrived, another settlement was awarded —the largest yet—of $5.4 million. By September of that same year, the evidence that was submitted to the FDA was determined insufficient to judge whether breast implants were safe or unsafe, and they were required to submit further data. Three months later another case against Dow Corning was won, with $7.3 million awarded. Another 137 lawsuits were pending. In 1992, the FDA clamped down and severely limit the use of silicone breast implants. By 1995, Dow Corning was facing some 20,000 lawsuits and a global settlement suit in which about 440,000 women had registered. Dow filed for bankruptcy. The court heard plaintiffs’ testify that their ruptured and leaking implants were causing them a range of health problems including joint pain, headaches, autoimmune diseases, connective tissue diseases, arthritic-like conditions, chronic fatigue, muscle pain, and dizziness. The verdict seemed to be that there were grave problems with the use of silicone from the beginning, and that it’s containment within a silicone bag did little to limit it’s adverse effects within the body. This was the conclusion of not only the growing numbers of “implant survivors” but that of a growing body of experts as well. Dr. Pierre Blais was the former Senior Scientific Advisor for Canada’s now-defunct Department of Health and Welfare for fourteen years. He now runs Innoval Consultants, a firm engaged in the design, testing and failure analysis of high risk medical systems In his line of work he has examined over 7,000 cases of explantation, from which they have recovered over 9,000 different implants. Blais says they’ve seen “every single type that has ever been used worldwide. Some are as old as the 1950’s.” “[They’re] mostly of US manufacturing origin because they dominate the field.” Blais continues: “what we’re seeing is an unprecedented degree of poor quality. It doesn’t matter where you get them from, it doesn’t matter when they were put in, what we see consistently across all years and all types is very poor quality, frequent manufacturing defects, and in almost all cases, major problems that arose as a result of the implant. At the very least, a poor appearance; at the very worst, death. “We have a very substantial number of these implants which were removed at death. We call that necropsy.” In October of this year, Health Canada made a strange move - the decision to lift the restrictions on silicone implants that have been in place for over fifteen years, specifically for two corporations - Inamed and Mentor. What has changed between the early 90’s—when the ban was put into effect—and now? Health Canada’s Dr. Supriya Sharma told CTV Newsnet on Oct. 20 of this year that there have been many changes since the early 90’s in terms of how silicone implants are manufactured. “It’s an illusion,” stresses Blais. “Basically, the technology’s exactly the same, the materials are still the same […] the same people who were around in the 60’s, 70’s and 80’s making breast implants are still around. Only the names of the companies have changed as a result of multiple acquisitions, bankruptcies, problems, movement of the company abroad and so on.” Sharma went on to say that Health Canada believed that because the gel inside and the layers on the outside of silicone breast implants is now thicker, it is a safer product than it was in the 90’s. Blais disagrees. “It’s a total misconception,” explains Blais. First of all, “there is no such thing as ‘silicone’ in the singular. It’s thousands of different compounds, mixed very much like rubbers. [...] There is enormous variations between silicones. It’s no more descriptive a term [to say silicone] than it is to say, ‘rubber’. “In the case of breast implants, even the process to make breast implants does not ensure uniformity from implant to implant of the same batch, and we have instances where the silicones are from the same implant and yet have different properties from point to point. It’s extremely variable.” This makes it very difficult to determine the safety of silicone implants and how they behave in a woman’s body, says Blais. Even if there had been long-term testing or studies done in the 60s before silicone breast implants went on the market, Blais says that “the studies would apply specifically, only, to the batch of product that has been studied. It would not apply to anything before, and most probably nothing after.” How is it, then, that Health Canada managed to approve silicone implants with confidence? They cite reviews from the UK and the US that conclude there is “no evidence of a causal relationship between silicone gel-filled implants and a number of auto-immune diseases or other systemic illnesses.” They also cite a Canadian study that “showed that women undergoing cosmetic breast augmentation do not appear to be at an increased long-term risk of developing cancer,” and a publication published in an American journal that showed that “women undergoing cosmetic breast augmentation do not appear to be at an increased long-term risk of developing cancer.” They also established an Expert Advisory Panel to advise Health Canada in their decision. The integrity of the Expert Advisory Panel was called into question in early Nov. of 2005. The Canadian Medical Association Journal (CMAJ) reported that Nanaimo/Cowichan MP Jean Crowder was calling for the removal of three of the panel members because all three had either worked for, or accepted money from Inamed and Mentor. These were the very companies who’s breast implant license applications, and safety and efficacy data, were under review. Two panel members—Dr. Harold Brandon from Washington University and Dr. Michael Brook from McMaster University—had accepted money from Inamed to make presentations on behalf of the company at FDA hearings five months before being appointed to the Health Canada Expert Advisory Panel. “It was shameful and outrageous,” says Dr. Diana Zuckerman, president of the National Center for Policy Research for Women & Families, “but at least in the US it was clear that they were paid consultants, there to make a presentation on behalf of the company about how great the product is. In Canada, that wasn’t the case.” Panel member Dr. Mitchell Brown of Sunnybrook & Women’s College Health Sciences Centre was busy being paid to promote the (as-yet-unapproved) implants at his clinic and writing in a medical journal about “when silicone gel implants are reintroduced” a full year before they were officially given the green light by Health Canada (emphasis added). “It distresses me greatly that Health Canada has decided to lift the ban on silicone gel implants,” says Patty Faussett, who received implants in 1997 and had them out the following year after experiencing Multiple Sclerosis-type symptoms. “We’ve been shouting and waving our arms for years trying to get [experts’] attention about these very real dangers to so many women, but they have chosen to disregard the many reports of women harmed, in favor of profits for the corporations. ” Fausset says that before she had the implants, she wasn’t sick in over ten years. After having them out, she got tests back from a rheumatologist that told her that she had an elevated rheumatoid factor (80% of people with rheumatoid arthritis have this, and it is also linked with autoimmune diseases), a lowered C3 Complement and macrocytosis (the enlargement of red blood cells that is linked to liver disease, bacterial overgrowth and parasitic infestation, among other things). And here’s the catch—Patty Faussett’s implants were saline. Canada is only now lifting its ban on silicone implants—however, saline-filled implants have been on the market since the 60’s. Although saline is generally regarded as a safe alternative to silicone, Blais insists this is not the case. “The main problem with saline,” asserts Blais, “is that the companies who make them do not make the port—the valve, as it is called—secure. The result is that during the lifetime of the implant, the patient’s body fluids percolate or leak back into the implant, and this stuff rots ‘in situ’. In other words, blood, proteins and tissue which somehow finds its way into the implant becomes entrapped within the implant and sooner or later bacteria and fungi goes in too, and it uses the patient’s fluids and protiens as food. And it then grows.” Blais says the valves used in today’s saline implants are the same valves used on saline implants in 1976, and in 80% of saline implants, the valves come from the same manufacturer. Another problem that arises with saline implants is that the silicone bag around the saline is porous, and becomes more and more porous over time—notably so, according to Blais, after a period of about five years. “As more and more fluid from the patient becomes pumped into the [implant], the water part of this fluid leaks out through the bag, making the inside more and more concentrated with decaying tissue. It acts as a concentration machine where the inside is the nest for ongoing—what we call in our trade—colonization.” Following Blais down the rabbit hole of this grotesque underground world of butchered beauty, I wondered aloud what that would look like. He was only too happy to oblige with a description, remarking that the saline implants that were sent to him were “always like that.” “Even for the implants where the effect is not so ‘gross’, in other words, you don’t see a huge amount of foreign stuff stuck inside—like a bad aquarium? You find that when you look at the fluid closely. The particles and the inoculae—the ‘seeds’, so to speak, of the bacteria—are already there after a year. The amount increases with time. “Occasionally, very rarely, we will get one that is not badly colonized after five or six years but more than 80% of them have such a level of contamination on the inside that you can see it by looking at the implant at a distance of one meter. In some cases the implants are totally black.” So is there no way to make both silicone and saline implants high quality, safe products? Can’t technology save us in our quest for the perfect pair of breasts? Blais, who has been in the business of failed implants, among other things, for over a quarter of a century, doesn’t mince his words. “A breast implant—or for that matter, most implants—don’t just sit there. They cause the tissue around them to reshape, to re-form in a different way. In other words, the implant does not accommodate to the patient, the patient accommodates to the implant. “Firstly, the implant becomes surrounded by a tissue layer which gradually increases in thickness with time. Think of it as a tissue envelope, containing an implant. The space around the implant that is still within the capsule is usually a liquid. This liquid is stagnant. It’s like a marsh. There is no automatic cleansing of this fluid by body processes. “So, the liquid being stagnant in turn causes the death of the surrounding tissue. So as a result, the capsule becomes thicker and thicker. With time, there is less and less cleansing, and after about ten years, processes that are never found in living organisms without implants takes place. “For example, large quantities of very hard, glass-like calcific deposits form, and in large amounts. I’ve seen implants removed after twenty years where the surrounding tissue was like a mass of leather with the inside part consisting of [something like] crushed lightbulbs. “This is not an exception. The near-totality of implants that were put in between 1962 to about 1980 that are now being removed come out in this condition. It’s not just a statistical risk. It’s a…” Blais pauses, searching for the word, “ …guarantee. And the guarantee is that it’s the result of the way we are built.” “Now, it doesn’t stop there.” My head is reeling, and I consider asking him to slow down, but Blais is just getting warmed up. “A breast implant sits at the crossroads of a lot of machinery. The chest is not just a bag of tissue in which you can put anything. When you put an implant into a place like this, you force it between muscles, you have it sit on top of arteries, veins, lymphatic tissue and what-have-you. “So as a result, all of these other bits of machinery that we call our anatomy are changed. For example, blood flow into the chest is drastically reduced. Part of this blood is part-and-parcel of our coronary system. Basically the mammary artery, which is often very close to these implants, is affected to the point that it seizes to function and it calcifies. And that’s again, an expected [result]. “With time, the implants exert a sustained pressure. […] As a result of this sustained pressure, the ribcage gradually collapses and indents. We have patients where X-rays show incurvation or collapse of individual ribs that sit underneath the implant. And on and on it goes. It’s not rocket science, it’s just the way we are made.” With that final nail banged in the coffin, I turn to the question of how did we, as women, as a society, get to this point? In all this obsession over the appearance of our breasts—how big, how pert, how they spill over, their upward (or downward) tilt—I feel like something has been lost. We have forgotten what the biological function of breasts was in the first place. Faussett brought it home for me. “There is no doubt that the female breast has been considered one of a woman’s most alluring features. I don’t think that will ever change,” she muses, “but the difference is that in societies [in the] past, the female breast was the source of nourishment that meant life or death for an infant. The very survival of humankind depended upon the functioning human breast. In modern times, this is no longer the case. Yes, breasts are still nourishment for infants worldwide, but in our culture, we’ve made it optional to the health of the infant. Formula abounds for the woman who does not want to use her breasts as they were intended to be used. Couple the rise of the Playboy empire with the advent of easily-obtainable infant formulas, and, the breast has become more glamourous and sexy than ever before.” And of course, this glamour has a downside. “Breast implants are deceptive. They give women hope that they, too, can have glamourous, sexy breasts. Unfortunately, that is not always the case,” says Faussett. “Hard breasts are not sexy. Obviously fake breasts are not sexy. Numb breasts greatly reduce sexual pleasure. And if you happen to be one who suffers from immune system dysfunction as a result of exposure to breast implants, you can pretty much forget about sex, as the last thing you will ever feel is sexy. Instead, you will feel like you are an eighty year old woman in a much younger body as you fight to function normally. It is definitely not sexy.” However, Faussett asserts, “there is a dark side, and there is the lighter side, which I think I’ve found when I realized that my experience brought me closer to living a life that is purposeful, joyful and satisfying, and without all the baggage of insecurity about my body that I had. […] I realized my inward beauty more than ever, regardless—or in spite of—my suffering.” Addendum: as of Nov 17, the US FDA has decided it, too will be lifting the ban on silicone breast implants (but not silicone testicular implants, because of “inadequate testing”). For more information, visit the implant awareness website I am setting up at www.implanttruth.jshood.com It will include audio of the full interview with Dr. Pierre Blais, as well as links to Dr. Diana Zuckerman’s, Patty Faussett’s, Kathy Nye’s and many other survivors’ and experts’ sites, and much more. ~~~~~~~~~~~~~~ www.BreastImplantAwareness.org/ www.BreastImplantInfo.org/ www.BreastImplantAwareness.org/Patty.html http://kathynyebreastimplants.homestead.com/ |
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Merck Mouth, Myrl Jeffcoat, claims Gardasil can "Return them to Health" ... FALSE FALSE FALSE FALSE FALSE FALSE FALSE
By Health Lover, Ilena Rosenthal
http://ilenarose.blogspot.com First published in the San Diego Business Journal, 1998 ... still true today. Merck Myrl's buddies at Quackwatch hate me with such a vengence .... especially since they have a nearly half million dollar judgement against them with $312,000 still unpiad. They use Myrl ... who has proven herself to be a fatithful liar, stalker, screamer, and co-hater with the Quackwatch credo. They are attack dogs ... out to harm any who oppose the pharma / med device / chemical industry bottom lines. www.BreastImplantAwareness.org/Smokescreen.htm http://ilena-rosenthal.blogspot.com The Silicone Smokescreen The purpose of law is to prevent the strong from always having their way. ~~Ovid, 43 BC -- 18 AD Ovid must be spinning in his grave! For 35 years, silicone manufacturers have been selling harmful breast implants -- products the FDA never approved. (update: in November, 2006, after 40 years, the FDA caved in to industry demands and gave 'safety approval' with many unenforceable conditions to Inamed & Mentor for silicone breast implants. Dr. Sidney Wolfe said it best: The approval makes a mockery of the legal standard that requires “reasonable assurance of safety.”) Following in the footsteps of their cousins --The Tobacco Barons -- the mighty Dows and other silicone manufacturers have run roughshod over the*legal system. They followed the winning formula: Bury all incriminating evidence. Deny its existence. Make the victims prove your product is not safe. Even then, deny it. Put profit over human life. Deny it. Create an incestuous relationship with the AMA and the FDA. Deny it. Hire expensive PR firms to sway public opinion. Purchase favorable media with mega-advertising dollars. Deny it. Sell sex. Above all, create a "smokescreen" to confuse and confound the issue and protect your bottom line. Repeatedly claim that "there is no scientific proof that smoking (or silicone) causes" disease." It's easy. Human beings make lousy lab rats. Tobacco has honed this formula beautifully for well over 50 profit-filled years. We've really "come a long way, baby." However, it wasn't until October 1996 (Science, October 18) after thousands of studies and tens of millions of smoking-related deaths, that medical science was able to identify a "missing link" between smoking and lung cancer. Finally, proof. By then was there any doubt? Already, a half a million Americans were dying annually from smoking related diseases. "Tobacco science" had proven what everyone has known for decades. Since the 60's, the silicone manufacturers, claiming no culpability, out of court and out of the public eye, s'ettled thousands of cases of implant problems with "gag" orders which kept their "dirty little secrets" hidden. When one brave woman, Mariann Hopkins, refused to be silenced and took her case to jury, former San Diegan Dan Bolton dropped a bombshell on the jury and produced vast amounts of damning evidence from Dow's own files. Included were concealed studies showing how for years, Dow Corning knew, denied and hid the serious dangers. Dow lost all appeals, and the Supreme Court eventually upheld the verdict of fraud. One of the studies that surfaced was the Dow sponsored, 1975 ACTA from Sweden which indicated that silicone crosses the placental barrier. As far reaching as this fact is, to date, physicians nationwide continue to assure implanted women that it is perfectly safe to carry and nurse babies. Not one OB/GYN can tell me on what scientific studies these assurances are based. None exists. Retired professor of Health Education, Henrietta Farber is appalled at the lack of information given women today as to the true risks of implants. A survivor of double mastectomies and a series of disastrous implant surgeries, she is shocked that Dr. Anne Wallace, UCSD Plastic Surgeon, still quotes small, manufacturer financed studies as "proof" of implant safety. "Similar studies, could not have shown any correlation between smoking and cancer. Dr. Wallace ignores newer studies indicating that 34% of post mastectomy patients required additional surgery within the first five years after implantation." Dr. Wallace, whose recent lecture aired on UCSD-TV, described saline implants as "bags of water," never mentioning the fungus, mold and bacterial infections known to flourish in these degradable silicone envelopes. Mrs. Farber added, "Over 33,000 women have filed complaints of serious complications to the FDA about their saline implants. People believe incorrectly that they have been approved by the FDA for safety." However, on KNSD-TV, "Dirty Doctor" Dean Edell, describes saline implants as "perfectly safe, perfectly fine." He has also been heard proclaiming that he hopes that "implanted women never get a penny" from the makers of their defective products. Oh yes, the pennies. Dow spent $191 million defending itself in the three years prior to declaring bankruptcy in 1992 and crashing the huge class action suit. Meanwhile, while safely in "bankruptcy protection" Dow Corning enjoyed profits of $61 million in 1996, while Papa Dow Chemical earned $452 million in the first quarter of 1997. Concurrently, here in San Diego County, there are estimated hundreds of women with no funds to have their disintegrating and ruptured implants removed. Many are too ill with multiple autoimmune diseases to care for themselves and their families. Brilliant as they were, The Dows made some early serious calculation errors as to "cost benefit." Using strategy modeled after the exploding Pinto gas tanks, as the numbers of ruptured implants surfaced, they hid the details and continued to claim falsified rupture figures of only 1-5%. Well-respected UCSD Radiologist, Dr. Michael Middleton, presented details of research done on 1,200 women to the Annual Meeting of the Radiological Society of North America in November, 1995. He explained that in these studies on women implanted between 10 and 12 years, "The rupture rate for non polyurethane-coated implants was 31%, compared to 91% for polyurethane-coated implants." The latter were taken off the market in 1991 after it was discovered that the polyurethane breaks down to TDA, a known carcinogen. I've heard of no women, however, who received a "recall notice." The infamous class action suits have been brilliant stalling devices to keep the money where the manufacturers want it. Mentor Corporation of Santa Barbara, threatening bankruptcy, forced all recipients to settle with a "take it or leave it" offer. Their 1996 earnings were $23.8 million. One of their customers, a 43 year old San Diegan woman who had had 3 sets of failed implants, Mentor¹s being one, has now reluctantly been forced into receiving public assistance. She has had 12 implant related surgeries, has accumulated over $120,000 in medical bills, and lives in constant pain. Her total settlement from Mentor -- $379.90. "It is unbelievable to me, that women dying, and those who will suffer agonizing pain for the remainder of their lives are barred from seeking legal recourse through our court system." For this reason, explains Joan Huffman, Executive Director of La Jolla based Research Update, they have sponsored Assembly Bill 1609, which recently received an affirmative vote from the Senate Judiciary Committee. "Women harmed by breast implants deserve access to the court system." "Silicone Science" like "Tobacco Science" can rage in controversy for decades. And just like tobacco, the evidence is the victims and their failed health. They know now what science may not figure out (or admit to) for years. With insurers such as Blue Cross/Blue Shield denying benefits to "women with a history of implants," this is a public health catastrophe in the making. And the tax payer, as always, will have to pick up the tab. May Ovid rest in peace. Ilena Rosenthal ©1997 |
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Merck Mouth, Myrl Jeffcoat, claims Gardasil can "Return them to Health" ... FALSE FALSE FALSE FALSE FALSE FALSE FALSE
Subject: Women's Institute for Silicone Education and Research Date: Mon, 26 May 2008 12:39:06 -0600 Note from Health Lover, Ilena Rosenthal: www.BreastImplantAwareness.org/ Since the only other reference to this was written by Corporate Mouth, Junk Journalist Steven Milloy (close business etc friends with Andrew M Langer) ... this is beginning to seem like another attack of the corporations and their attorneys that Milloy etc. wages ... on the plaintiffs bar and health activists. The false and revealing accusation by Myrl Jeffcoat that I was paid by Burson-Marsteller is to me, akin to her claiming I worked with silicone sellers with she & Coleah having taken over the "Patrick O'leary Cause." www.BreastImplantAwareness.org/andysposse.htm http://www.BreastImplantAwareness.or...#Andrew-Langer Andrew Langer, a professional fake "sound sound expert" for years was embedding into the breast implant issue working closely with Coleah & Myrl. I further do not yet understand why for some reason Sybil Goldrich is not being directly asked since Milloy's propaganda exposing this entity was that this related to her in some way. If I were a bettin' woman ... I would bet that Milloy and Barrett and the rest of the Quackwatch / Junk Science corporate PR 'whores' ... are using Myrl & Coleah & Pam as "insiders" of the breast implant cause to help them augment their years of legal and PR attacks against plaintiff's attorneys and activities. http://www.BreastImplantAwareness.or...WatchWatch.htm On the earlier thread where Myrl Jeffcoat specifically was screeching about anti-vaccination and anti-amalgam research which was coming obviously from the voices in her head ... the most notable PR team is the Junk Science / Quackwatch Snake-oil Vigilante team that heads those (and other health issue corporate positions throughout Usenet and the rest of the internet.) http://groups.google.com/group/alt.s...18048724c6995# I will be posting more about what my studies on SKAFF (also a Milloy revelation) and the Common Benefit Fund when I catch a moment. www.BreastImplantAwareness.org/Snake-oil.htm www.BreastImplantAwareness.org/myrl.html Myrl ... the answer to your very self revealing question you keep repeating ... no I do not work with any silicone manufacturing entitity nor have I ever, and I receive no money from Burson Marsteller or any of their quacky frontgroups etc. ... nor do I receive compensation in any way from any attorney or claimants groups. www.BreastImplantAwareness.org/Andysposse.htm Myrl, Patrick O'leary, Andrew Langer, Coleah Penley Ayers, etc. etc. Very interesting ... www.BreastImplantAwareness.org/ http://ilena-rosenthal.blogspot.com Pam Dowd wrote: Women's Institute for Silicone Education and Research Anyone know what this is/was? Who was involved? Did any research ever come out of it? I had never seen this organization mentioned until recently. Pam Dowd Implant Veterans of Toxic Exposure |
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Merck Mouth, Myrl Jeffcoat, claims Gardasil can "Return them to Health" ... FALSE FALSE FALSE FALSE FALSE FALSE FALSE
Wow ... Myrl ... finally Coleah came back to battle me on this thread
with you. Whewwwwwwwwwww. You two old biddies have been promoting the quackery of my 3 losing plaintiffs for years. http://www.BreastImplantAwareness.or...sRosenthal.htm Subject: Aluminum is the new mercury Note from Health Lover, Ilena Rosenthal Director, Humantics Foundation www.ilenarose.blogspot.com I was very happy to see the title of this thread. I became aware that the aluminum industry also had a huge coverup of the dangers campaign when the Snake-oil Vigilantes and Myrl & Coleah began defending aluminum with the identical tactics used to defend mercury, various chemicals, breast implants etc. When I began posting about aluminum in every Gardasil jab ... Myrl & Coleah sprang to it's defense ... as did several others on this team .... www.BreastImplantAwareness.org/Snake-oil.htm Happy Sunday to all ... as the 7th anniversary of the well planned 911 conspiracy approaches ... may we all be protected from the perpetrators. http://ilena-rosenthal.blogspot.com Here are so earlier threads on aluminum ... and I am going to expand this subject to other relevant newsgroups. ~~~~~~~~~~~~~~~~~~~ The 'they' Jeffcoat is screaming about ... are those of us concerned with the harm being caused to many by vaccinations and the cover-up surrounding it. Myrl Jeffcoat: They yell about the aluminum content in each vaccine. . .An amount, less than in a single serving of Spinich, Parmesan Cheese, and a litany of other healty foods. " http://groups.google.com/group/alt.s...2e1e90fd0732d1 ~~~~~~~~~~ It's as if Coleah Penley Ayers is channeling Stephen Barrett himself in her "good news" about the long term accumulation of aluminum if pre-pubescent girls when she spouts this perfect Quack Logic : ~~~~~~~~~~~ Coleah: And Aluminum Hydrodine (used in Gardasil) is the safest aluminum compound (see my previous post for reference link)...yes, it is safer than what is used to purify water and that which is used as a food additive. So what is the big scary point? ~~~~~~~~~~~~~~~~~ http://www.hbci.com/~wenonah/hydro/al.htm Use: As the pure metal or as alloys (magnalium, aluminum bronze, etc.) for aircraft, utensils, apparatus, electrical conductors; instead of copper in dental alloys. The coarse powder is used in aluminothermics (thermite process); the fine powder as flashlight in Photography, in explosives, fireworks and in aluminum paints; for absorbing occluded gases in manuf. of steel. In testing for Au, As, Hg; coagulating colloidal solns. of As or Sb; pptg. Cu; reducer for determining nitrates and nitrites; instead of Zn for generating hydrogen in testing for As. Grades available: Reagent, technical. ------------------------------------------------------------------ Aluminum Toxicity The following information was compiled and submitted by Frank Hartman. "From the earliest days of food regulation, the use of alum (aluminum sulphate) in foods has been condemned. It is universally acknowledged as a poison in all countries. If the Bureau of Chemistry had been permitted to enforce the law ... no food product in the country would have any trace of ... any aluminum or saccarin. No soft drink would contain caffeine or hebromin; no bleached flour would be in interstate commerce. Our food and drugs would be wholly without adulteration ... and the health of our people would be vastly improved and their life greatly extended." From History of crime against the Food Laws (1929) by Dr. Wiley, the prime mover behind the original Pure Food Law and Director of the FDA. He resigned in disgust in 1912 over exceptions granted to the law and lack of enforcement. Aluminum has been exempted from tesitng for safety by the FDA under a convoluted logic wherein it is classified as GRAS. (Generally Regarded As Safe.) It has never been tested by the FDA on its safety and there are NO restrictions whatever on the amount or use of aluminum. There are over 2000 references in the National Library of Medicine on adverse effects of alumium. The following were extracted to provide a small sample of the range of toxicity of aluminum. Chemical Registry Aluminum toxicity has been recognized in many settings where exposure is heavy or prolonged, where renal function is limited, or where apreviously accumulated bone burden is released in stress or illness. Toxicity may include: encephalopathy (stuttering, gait disturbance, myoclonic jerks, seizures, coma, abnormal EEG) osteomalacia or aplastic bone disease ( associated with painful spontaneous fractures, hypercalcemia, tumorous calcinosis ) proximal myopathy, increased risk of infection, increased left ventricular mass and decreased myocardial function microcytic anemia with very high levels, sudden death. Aluminum is ubiquitous in our environment; it is the third most prevalent element in the earth's crust. The gastrointestinal tract is relatively impervious to aluminum, absorption normally being only about 2%. Aluminum is absorbed by a mechanism related to that for calcium. Gastric acidity and oral citrate favors absorption, and H2-blockers reduce absorption. As is true for several trace elements, transferrin is the primary protein binder and carrier for aluminum in the plasma, where 80% is protein bound and 20% is free or complexed to small molecules such as citrate. Cells appear to take up aluminum from transferrin rather than from citrate. Purified preparations of ferritin from brain and liver have been found to contain aluminum. It is not known if ferritin has a specific binding site for aluminum. Factors regulating the migration of aluminum across the blood–brain barrier are not well understood. Serum aluminum correlates with encephalopathy; red cell aluminum correlates with microcytic anemia, and bone aluminum correlates with aluminum bone disease. Basal PTH when elevated appears to protect bone and thereby favor CNS toxicity. Other factors favoring one form of toxicity over another are not well understood. Aluminum toxicity has been reported to impair the formation and release of parathyroid hormone. The parathyroid glands concentrate aluminum above levels in surrounding tissues. Treatment of aluminum toxicity in renal failure patients often reactivates hyperparathyroidism, which to a certain extent is helpful for bone remodeling and healing. Distilled Water Placed in Various Containers Distilled water was placed in metal containers and the amount of the "Metal Can" that disolved into the distilled water was measured daily using Specific Conductance readings. You can divide the SC number by 2 to get the approxamite amount of atoms in ppm ( mg / l ). 4 ppm of aluminum in human blood can cause it to colagulate. Aluminum in humans is documented to Inhibit Learning. See Below ... -------------------------------------------------------------------------------- Aluminum neurotoxicity in preterm infants receiving intravenous-feeding solutions. Bishop N.J. – Morley R. – Day J.P. – Lucas A. From: N Engl J Med (1997 May 29) 336(22):1557-61 Aluminum, a contaminant of commercial intravenous–feeding solutions, is potentially neurotoxic. We investigated the effect of perinatal exposure to intravenous aluminum on the neurologic development of infants born prematurely. RESULTS: The 90 infants who received the standard feeding solutions had a mean (± SD) Bayley Mental Development Index of 95 ±22, as compared with 98 ±20 for the 92 infants who received the aluminum-depleted solutions (P=0.39). The former were significantly more likely (39 percent, vs. 17 percent of the latter group; P=0.03) to have a Mental Development Index of less than 85, increasing their risk of subsequent educational problems. For all 157 infants without neuromotor impairment, increasing aluminum exposure was associated with a reduction in the Mental Development Index (P=0.03), with an adjusted loss of one point per day of intravenous feeding for infants receiving the standard solutions. In preterm infants, prolonged intravenous feeding with solutions containing aluminum is associated with impaired neurologic development. -------------------------------------------------------------------------------- Aluminum-containing emboli in infants treated with extracorporeal membrane oxygenation. Vogler C. – Sotelo-Avila C. – Lagunoff D. – Braun P. – Schreifels J.A. – Weber T. From: N Engl J Med (1988 Jul 14) 319(2):75-9 We found fibrin thrombi or thromboemboli at autopsy in 22 of 23 infants with respiratory failure who had been treated with venoarterial extracorporeal membrane oxygenation (ECMO). In addition, distinctive basophilic aluminum-containing emboli were found in 12 of the infants; the distribution of these emboli was similar to that of the thromboemboli, except that an aluminum-containing embolus was found in a lung in only 1 infant. Sixteen infants had pulmonary thrombi or thromboemboli. We also found friable aluminum-containing concretions adhering loosely to the mixing rods of heat exchangers that had been used to warm the blood flowing through the ECMO circuit; such concretions were not present on unused mixing rods. We propose that these aluminum-containing concretions developed as the silicone coating of the heat exchanger wore away and aluminum metal was exposed to warm, oxygenated blood and that fragments of aluminum-containing concretions formed emboli. This hypothesis is supported by the fact that aluminum-containing emboli were generally not present in the lungs, which are bypassed by ECMO. -------------------------------------------------------------------------------- Sequential serum aluminum and urine aluminum: creatinine ratio and tissue aluminum loading in infants with fractures/rickets. Koo W.W. – Krug-Wispe S.K. – Succop P. – Bendon R. – Kaplan L.A. From: Pediatrics (1992 May) 89(5 Pt 1):877-81 Aluminum toxicity is associated with the development of bone disorders, including fractures, osteopenia, and osteomalacia. Fifty-one infants with a mean (± SEM) birth weight of 1007 ±34 g, gestational age of 28.5 +/-0.3 weeks, and serial radiographic documentation at 3, 6, 9, and 12 months for the presence (n = 16) or absence (n = 35) of fractures and/or rickets were studied at the same intervals to determine the serial changes in serum aluminum concentrations and urine aluminum-creatinine ratios. Autopsy bone samples were used to determine the presence of tissue aluminum. One infant who received aluminum-containing antacid had marked increase in serum aluminum to 83 micrograms/L while urine aluminum-creatinine ratio increased from 0.09 to a peak of 8.53. Vertebrae from three infants at autopsy (full enteral feeding was tolerated for 37 and 41 days in two infants, respectively) showed aluminum deposition in the zone of provisional calcification and along the newly formed trabecula. -------------------------------------------------------------------------------- Aluminum in parenteral solutions revisited — again. Klein G.L. From: Am J Clin Nutr (1995 Mar) 61(3):449-56 It has been a dozen years since aluminum was first shown to contaminate parenteral nutrition solutions and to be a contributing factor in the pathogenesis of metabolic bone disease in parenteral nutrition patients as well as in uremic patients. However, there are no regulations in place to effectively reduce aluminum contamination of various parenterally administered nutrients, drugs, and biologic products. The purpose of this review is fourfold: 1.) to summarize our knowledge of the adverse effects of aluminum on bone formation and mineralization in parenteral nutrition patients; 2.) to discuss the possible role of aluminum in the osteopenic bone disease of preterm infants; 3.) to show how lack of regulations covering aluminum content of parenteral solutions can lead to vulnerability of new groups of patients to aluminum toxicity, the example being given here is that of burn patients -------------------------------------------------------------------------------- Aluminum-induced anemia. From: Am J Kidney Dis (1985 Nov) 6(5):348-52 .... many questions still remain unanswered, it is clear that aluminum causes a microcytic hypoproliferative anemia and is a factor responsible for worsening anemia in patients with end-stage renal disease. Arch Dermatol (1984 Oct) 120(10):1318-22 Three patients had subcutaneous nodules at the sites of previous injections of vaccine containing tetanus toxoid, showed aluminum crystals in the nodules from two patients. From the evidence available, we believe that these nodules are a complication of inoculations with aluminum-containing vaccines. -------------------------------------------------------------------------------- Persistent subcutaneous nodules in patients hyposensitized with aluminum-containing allergen extracts. Garcia-Patos V. – Pujol R.M. – Alomar A. – Cistero A. – Curell R. – Fernandez-Figueras M.T. – de Moragas J.M. From: Arch Dermatol (1995 Dec) 131(12):1421-4 These lesions have been mainly attributed to a hypersensitivity reaction to aluminum hydroxide, which is used as an absorbing agent in many vaccines and hyposensitization preparations. Patch tests with standard antigens and aluminum compounds and histopathologic and ultrastructural studies were performed on 10 patients with persistent subcutaneous nodules on the upper part of their arms after injection of aluminum-adsorbed dust and/or pollen extracts. The nodules appeared 1 month to 6.5 years after injections. -------------------------------------------------------------------------------- Trace metals and degenerative diseases of the skeleton. Savory J. – Bertholf R.L. – Wills M.R. From: Acta Pharmacol Toxicol (Copenh) (1986) 59 Suppl 7:282-8 Aluminum related osteodystrophy is the most important manifestation of trace metal toxicity related to degenerative diseases of the skeleton. -------------------------------------------------------------------------------- Postvaccinal sarcomas in the cat: epidemiology and electron probe microanalytical identification of aluminum. Hendrick M.J. – Goldschmidt M.H. – Shofer F.S. – Wang Y.Y. – Somlyo A.P. From: Cancer Res (1992 Oct 1) 52(19):5391-4 An increase in fibrosarcomas in a biopsy population of cats in the Pennsylvania area appears to be related to the increased vaccination of cats following enactment of a mandatory rabies vaccination law. The majority of fibrosarcomas arose in sites routinely used by veterinarians for vaccination, and 42 of 198 tumors were surrounded by lymphocytes and macrophages containing foreign material identical to that previously described in postvaccinal inflammatory injection site reactions. Some of the vaccines used have aluminum-based adjuvants, and macrophages surrounding three tumors contained aluminum oxide identified by electron probe microanalysis and imaged by energy-filtered electron microscopy. Persistence of inflammatory and immunological reactions associated with aluminum may predispose the cat to a derangement of its fibrous connective tissue repair response, leading to neoplasia. -------------------------------------------------------------------------------- Aspects of aluminum toxicity. Hewitt C.D. – Savory J. – Wills M.R. From: Clin Lab Med (1990 Jun) 10(2):403-22 Attention was first drawn to the potential role of aluminum as a toxic metal over 50 years ago, but was dismissed as a toxic agent as recently as 15 years ago. The accumulation of aluminum, in some patients with chronic renal failure, is associated with the development of toxic phenomena; dialysis encephalopathy, osteomalacic dialysis osteodystrophy, and an anemia. Aluminum accumulation also occurs in patients who are not on dialysis, predominantly infants and children with immature or impaired renal function. Aluminum has also been implicated as a toxic agent in the etiology of Alzheimer's disease, Guamiam amyotrophic lateral sclerosis, and parkinsonism-dementia. -------------------------------------------------------------------------------- Soft tissue sarcoma associated with aluminum oxide ceramic total hip arthroplasty. A case report. Ryu R.K. – Bovill E.G. Jr – Skinner H.B. – Murray W.R. From: Clin Orthop (1987 Mar)(216):207-12 Malignant tumors around fracture fixation implants have been reported sporadically for many years. Recently, however, reports of sarcomatous degeneration around a standard cemented hip arthroplasty and around cobalt-chromium-bearing hip arthroplasties raise new questions of the malignant potential of metallic ends prostheses. Sarcomatous changes around aluminum oxide ceramics seem not to have been reported in the literature. The present report may be the first documented case of an aggressive soft tissue sarcoma detected 15 months after the patient had an uncemented ceramic total hip arthroplasty. If a causal relationship exists, the incidence of this phenomenon in the United States is 250 times greater than would be expected from statistics on soft tissue sarcoma at the hip. -------------------------------------------------------------------------------- Aluminum-induced granulomas in a tattoo. McFadden N. – Lyberg T. – Hensten-Pettersen A. From: J Am Acad Dermatol (1989 May) 20(5 Pt 2):903-8 Aluminum was the only nonorganic element present in the test site tissue. This is the first report of confirmed aluminum-induced, delayed-hypersensitivity granulomas in a tattoo. -------------------------------------------------------------------------------- Delayed healing in full-thickness wounds treated with aluminum chloride solution. A histologic study with evaporimetry correlation. Sawchuk W.S. – Friedman K.J. – Manning T. – Pinnell S.R. From: J Am Acad Dermatol (1986 Nov) 15(5 Pt 1):982-9 Wounds were treated either with 30% aluminum chloride solution or ferric subsulfate solution or were allowed to clot with minimal pressure from a gauze pad. Delay in reepithelialization was noted histologically both in wounds treated with aluminum chloride and in those treated with ferric subsulfate compared to controls. Presumably this delay was the result of tissue necrosis caused by these hemostatic agents, resulting in slightly larger and less cosmetically acceptable scars. Plots of evaporimetry data revealed a biphasic pattern of water loss during healing, with an initial rapid decline in water loss followed by a much slower decline. -------------------------------------------------------------------------------- Aluminium and injection site reactions. Culora G.A. – Ramsay A.D. – Theaker J.M. From: J Clin Pathol (1996 Oct) 49(10):844-7 To alert pathologists to the spectrum of histological appearances that may be seen in injection site reactions related to aluminium, showed unusual features not described previously. In one, there was a sclerosing lipogranuloma-like reaction with unlined cystic spaces containing crystalline material. The other case presented as a large symptomatic subcutaneous swelling which icroscopically showed diffuse and wide-spread involvement of the subcutis by a lymphoid infiltrate with prominent lymphoid follicles. CONCLUSIONS: This report highlights the changes encountered in aluminium injection site reactions and emphasises that the lesions have a wider range of histological appearances than described previously. -------------------------------------------------------------------------------- Aluminum and gallium arrest formation of cerebrospinal fluid by the mechanism of OH- depletion. Vogh B.P. – Godman D.R. – Maren T.H. From: J Pharmacol Exp Ther (1985 Jun) 233(3):715-21 AlCl3 or GaCl3 was added to artificial cerebrospinal fluid and perfused through the cerebral ventricles of the rat. Depending on the metal and its concentration (1-10 mM) the pH of the perfusate ranged from 7.2 to 3.5. At 10 mM metal chloride, yielding pH 4.7 (Al) or 3.5 (Ga), formation of cerebrospinal fluid was suppressed 100%. This mechanism may also account for the antiperspirant action of Al salts. -------------------------------------------------------------------------------- Aluminum toxicity and albumin. Kelly A.T. – Short B.L. – Rains T.C. – May J.C. – Progar J.J. From: ASAIO Trans (1989 Jul-Sep) 35(3):674-6 During a study of priming solutions for extracorporeal membrane oxygenation (ECMO) in the intensive care nursery, it was discovered that those solutions using certain brands of 25% albumin contained aluminum levels within the toxic range. When the brand was changed to a brand known to have a lower aluminum (Al) content, a marked drop in priming solution Al levels was measured. -------------------------------------------------------------------------------- The role of aluminium for adverse reactions and immunogenicity of diphtheria-tetanus booster vaccine. Mark A. – Granstrom M. From: Acta Paediatr (1994 Feb) 83(2):159-63 235 schoolchildren aged 10 years received either a regular, aluminium-adsorbed diphtheria-tetanus vaccine or the same vaccine in fluid form, in order to investigate if local side effects could be diminished by exclusion of aluminium. System reactions were rare and local reactions frequent in both groups but larger local reactions were even more pronounced in the non-adsorbed vaccine group. -------------------------------------------------------------------------------- Potroom palsy? Neurologic disorder in three aluminum smelter workers. Heyer N.J. From: Arch Intern Med (1985 Nov) 145(11):1972-5 We studied three patients with a progressive neurologic disorder, all of whom had worked for over 12 years in the same potroom of an aluminum smelting plant. All had incoordination and an intention tremor. Two of the three patients had cognitive deficits, and the most severely affected patient also had spastic paraparesis. None had involvement of the peripheral nervous system. Despite extensive evaluations, the cause of these patients' problems remains obscure. Neurotoxic effects of aluminum in animals are directed at the central nervous system, and theoretically long-term low-level exposure to aluminum in the potroom could explain the findings in our patients. -------------------------------------------------------------------------------- Reducing aluminum: an occupation possibly associated with bladder cancer Theriault G. – De Guire L. – Cordier S. From: Can Med Assoc J (1981) 124(4):419-422,425 These findings suggest that employment in an aluminum reduction plant accounts for part of the excess of bladder cancer in the region studied. (Author abstract) (85 Refs) -------------------------------------------------------------------------------- Immunohistochemical study of microtubule-associated protein 2 and ubiquitin in chronically aluminum-intoxicated rabbit brain. Takeda M. – Tatebayashi Y. – Tanimukai S. – Nakamura Y. – Tanaka T. – Nishimura T. From: Acta Neuropathol (Berl) (1991) 82(5):346-52 Experimental neurofibrillary change was produced in rabbit brain by daily subcutaneous aluminum tartrate injection for 40 days. -------------------------------------------------------------------------------- Neurotoxic effects of aluminium on embryonic chick brain cultures. From: Acta Neuropathol (Berl) (1994) 88(4):359-66 Toxic damage of brain cells by aluminium (Al) is discussed as a possible factor in the development of neurodegenerative disorders in humans. Effects of Al on cell viability (lysosomal and mitochondrial activity) and differentiation (synthesis of cell-specific proteins) were found to the brain area specific with the highest sensitivity observed in optic tectum. -------------------------------------------------------------------------------- Aluminium in tooth pastes and Alzheimer's disease. Verbeeck R.M. – Driessens F.C. – Rotgans J. From: Acta Stomatol Belg (1990 Jun) 87(2):141-4 The role of aluminium from tooth pastes may be even more important than that from the drinking water. -------------------------------------------------------------------------------- Persistent subcutaneous nodules in children hyposensitized with aluminium-containing allergen extracts. Frost L. – Johansen P. – Pedersen S. – Veien N. – Ostergaard P.A. – Nielsen M.H. From: Allergy (1985 Jul) 40(5):368-72 A follow-up study of 202 children who had received hyposensitization with aluminium-containingallergens showed that 1-3 years after cessation of hyposensitization 13 children still had severely treatment-resistant subcutaneous nodules in their forearms. Because of their long persistence the nodules of six children were studied in detail. Histologically, the nodules showed infiltration with lymphocytes (forming germinal centres), macrophages, plasma cells, mast cells and a few eosinophils. In five patients aluminium crystals were found scattered between the cells and, in addition, the phagosomes of the macrophages contained aluminium. Patch tests for aluminium were positive in four of the six patients. -------------------------------------------------------------------------------- Contact sensitivity to aluminium in a patient hyposensitized with aluminium precipitated grass pollen. Clemmensen O. – Knudsen H.E. From: Contact Dermatitis (1980 Aug) 6(5):305-8 Standard patch testing of a patient with eczema revealed positive reactions to the aluminium discs used for testing. -------------------------------------------------------------------------------- Behavioural effects of gestational exposure to aluminium. Rankin J. – Sedowofia K. – Clayton R. – Manning A. From: Ann Ist Super Sanita (1993) 29(1):147-52 The involvement of aluminium in the aetiology of a number of human pathological diseases has altered its status from being a nontoxic, nonabsorbable, harmless element. This maybe of particular concern to the developing foetus which is more susceptible to agents and at lower levels than the adult. Little attention has been given to aluminium's potential reproductive toxicity until recently and further research is required for a full evaluation of its toxicity. Our preliminary results demonstrate behavioural and neurochemical alterations in the offspring of mice exposed to aluminium during gestation. Further, the effects of such exposure are also present in the adult animal suggesting persistent changes in behaviour following prenatal exposure. -------------------------------------------------------------------------------- The absence of extracellular calcium potentiates the killing of cultured hepatocytes by aluminum maltolate. Snyder J.W. – Serroni A. – Savory J. – Farber J.L. From: Arch Biochem Biophys (1995 Jan 10) 316(1):434-42 This data defines a new model in which aluminum kills liver cells by a mechanisms distinct from previously recognized pathways of lethal cell injury. It is hypothesized that aluminum binds to cytoskeletal proteins intimately associated with the plasma membrane. This interaction eventually disrupts the permeability barrier function of the cell membrane, an event that heralds the death of the hepatocyte. -------------------------------------------------------------------------------- Sensitization to aluminium by aluminium-precipitated dust and pollen extracts. Castelain P.Y. – Castelain M. – Vervloet D. – Garbe L. – Mallet B. From: Contact Dermatitis (1988 Jul) 19(1):58-60 .... the means of sensitization was the inoculation of aluminium-precipitated pollen or dust extracts for hyposensitization. We conclude that aluminium allergy is not exceptional. -------------------------------------------------------------------------------- Allergy to non-toxoid constituents of vaccines and implications for patch testing. Cox N.H. – Moss C. – Forsyth A. From: Contact Dermatitis (1988 Mar) 18(3):143-6 Aluminium allergy causes false positive patch test reactions and we propose methods of patch testing patients with symptoms at vaccination sites in order to avoid this problem. -------------------------------------------------------------------------------- Aluminium allergy in patients hyposensitized with aluminium-precipitated antigen extracts. Lopez S. – Pelaez A. – Navarro L.A. – Montesinos E. – Morales C. – Carda C. Aluminum precipitated antigen solutions, a small percentage of patients develop persistent subcutaneous nodules at the injection site; the existence of delayed sensitivity to aluminium has been implicated in the pathogenesis of these nodules. -------------------------------------------------------------------------------- Aluminium allergy. Veien N.K. – Hattel T. – Justesen O. – Norholm A. From: Contact Dermatitis (1986 Nov) 15(5):295-7 13 children ranging in age from 1 to 13 years and 1 adult patient had positive patch tests to 2% AlCl3 in water. 13 of them had pruritic excoriated papules, 9 at sites of hyposensitization therapy with aluminium-bound pollen extracts, and 4 at sites of childhood immunization with an aluminium-bound vaccine (Di-Te-Pol). -------------------------------------------------------------------------------- Vaccination granulomas and aluminium allergy: course and prognostic factors. Kaaber K. – Nielsen A.O. – Veien N.K. From: Contact Dermatitis (1992 May) 26(5):304-6 21 children who had cutaneous granulomas following immunization with a vaccine containing aluminium hydroxide, and who had positive patch tests to aqueous aluminium chloride and/or to a Finn Chamber, were followed for 1 to 8 years. During the period of observation, the symptoms cleared in 5 children, improved in 11, and remained unchanged in 5. -------------------------------------------------------------------------------- Short-term experimental acidification of a Welsh stream: toxicity of different forms of aluminium at low pH to fish and invertebrates. McCahon C.P. – Pascoe D. From: Arch Environ Contam Toxicol (1989 Jan-Apr) 18(1-2):233-42 Minimal effects were observed in the control and acid zones whilst large mortalities and reduced feeding were recorded in the acid and aluminium zone. -------------------------------------------------------------------------------- H Differentiated neuroblastoma cells are more susceptible to aluminium toxicity than developing cells. E. Meiri From: Arch Toxicol (1989) 63(3):231-7 Two specific questions were addressed: 1.) Can differentiated cells maintain their normal excitable function when exposed to aluminium? 2.) Can proper development of electrophysiological properties be achieved in its presence? We report that aluminium caused premature onset of deterioration in fully differentiated cells. Within 4-6 days they depolarized from -29.3 ±0.9 mV to levels lower than -15 mV; compound polyphasic action potentials were gradually replaced by slow monophasic spikes before the final loss of excitable properties and structural deformations was noticed. -------------------------------------------------------------------------------- Reversal of an aluminum-induced behavioral deficit by administration of deferoxamine. Connor D.J. – Harrell L.E. – Jope R.S. From: Behav Neurosci (1989 Aug) 103(4):779-83 The behavioral deficit was not due to nonspecific effects caused by lower fluid consumption. Partial reversal of the deficit was produced by discontinuing aluminum treatment, 2 weeks prior to testing. -------------------------------------------------------------------------------- Aluminum-induced neurofibrillary degeneration disrupts acquisition of the rabbit's classically conditioned nictitating membrane response. Pendlebury W.W. – Perl D.P. – Schwentker A. – Pingree T.M. – Solomon P.R. From: Behav Neurosci (1988 Oct) 102(5):615-20 Aluminum intoxicated rabbits, in contrast, did not acquire the conditioned response over the 4 days of testing. This disruption of conditioning in aluminum-treated rabbits could not be attributed to deficits in sensory or motor processes or to illness. Neuropathological analysis revealed widespread neurofibrillary tangle formation in aluminum-treated animals. -------------------------------------------------------------------------------- Aluminum, a neurotoxin which affects diverse metabolic reactions. Joshi J.G. From: Biofactors (1990 Jul) 2(3):163-9 Experimental evidence is summarized to support the hypothesis that chronic exposure to low levels of aluminum may lead to neurological disorders. -------------------------------------------------------------------------------- Distribution of aluminum in different brain regions and body organs of rat. Vasishta R.K. – Gill K.D. From: Biol Trace Elem Res (1996 May) 52(2):181-92 In the present study, an attempt has been made to investigate the distribution of aluminum in different regions of brain and body organs of male albino rats, following subacute and acute aluminum exposure. Aluminum was observed to accumulate in all regions of the brain with maximum accumulation in the hippocampus. Aluminum was also seen to compartmentalize in almost all the tissues of the body to varying extents, and the highest accumulation was in the spleen. -------------------------------------------------------------------------------- Ti-6Al-4V ion solution inhibition of osteogenic cell phenotype as a function of differentiation timecourse in vitro. Thompson G.J. – Puleo D.A. From: Biomaterials (1996 Oct) 17(20):1949-54 These results indicate that ions associated with Ti-6Al-4V alloy inhibited the normal differentiation of bone marrow stromal cells to mature osteoblasts in vitro, suggesting that ions released from implants in vivo may contribute to implant failure by impairing normal bone deposition. -------------------------------------------------------------------------------- Aluminium release from glass ionomer cements during early water exposure in vitro. Andersson O.H. – Dahl J.E. From: Biomaterials (1994 Sep) 15(11):882-8 Aluminium is a major constituent of glass ionomer cements. During mixing and setting aluminium is released from the glass into the polyalkeonic acid solution. Part of this aluminium may not combine with the polyalkeonic acid, but may be released from the cement. The aluminium release from auto-cured and light-cured glass ionomer cements during early water exposure was studied. The former cements released more aluminium than the latter. It is suggested that the considerable release of aluminium from glass ionomer cements during early water exposure may explain the reported lack of mineralization of predentin in the pulp beneath glass ionomer cements. This would correspond to the inhibiting effect of aluminium on bone mineralization. -------------------------------------------------------------------------------- Impaired control of information transfer at an isolated synapse treated by aluminum: is it related to dementia? Banin E. – Meiri H. From: Brain Res (1987 Oct 13) 423(1-2):359-63 These results indicate that aluminum at concentrations similar to those found in the diseased brain of demented patients modulates synaptic transmission. -------------------------------------------------------------------------------- Chronic aluminum-induced motor neuron degeneration: clinical, neuropathological and molecular biological aspects. Strong M.J. – Garruto R.M. From: Can J Neurol Sci (1991 Aug) 18(3 Suppl):428-31 Aluminum chloride induces aggregates of phosphorylated neurofilament that mimics the intraneuronal inclusions of amyotrophic lateral sclerosis. -------------------------------------------------------------------------------- Some commonly unrecognized manifestations of metabolic arthropathies. Cobby M.J. – Martel W. From: Clin Imaging (1992 Jan-Mar) 16(1):1-14 The metabolic arthropathies are characterized by the deposition of abnormal substances in or around joints. Certain features of some of these arthropathies and their significance have only recently been recognized and others have been insufficiently emphasized. An important group of conditions are the arthropathies related to renal failure and its treatment, namely, aluminum toxicity, periarticular calcification and crystal deposition, hyperparathyroidism, and dialysis-related amyloidosis. Crystal deposition diseases, specifically, gouty arthritis, calcium pyrophosphate deposition, and calcium hydroxyapatite deposition, are also reviewed. -------------------------------------------------------------------------------- Sepsis: a cause of aluminum release from tissue stores associated with acute neurological dysfunction and mortality. Davenport A. – Williams P.S. – Roberts N.B. – Bone J.M. From: Clin Nephrol (1988 Jul) 30(1):48-51 We report six cases of patients with renal failure and exposure to aluminum who developed septicemia. In all cases the serum aluminum increased markedly. This may have contributed to the neurological dysfunction seen in five, and the deaths of four of the patients. We suggest that the rise in serum aluminum was due to the release of tissue-bound aluminum, resulting in an increase in free, diffusable aluminum and that this jeopardized both neurological function and immunocompetence. -------------------------------------------------------------------------------- Estimates of dietary exposure to aluminium. Pennington J.A. – Schoen S.A. From: Food Addit Contam (1995 Jan-Feb) 12(1):119-28 Daily intakes of aluminium were estimated for 14 age-sex groups based on the Food and Drug Administration's (FDA) Total Diet Study dietary exposure model. Estimates of aluminium intakes ranged from 0.7 mg/day for 6-11-month-old infants to 11.5 mg/day for 14-16-year-old males. Average intakes for adult men and women were 8-9 and 7 mg/day, respectively. The major contributors to daily intake of aluminium were foods with aluminium-containing food additives, e.g. grain products and processed cheese. -------------------------------------------------------------------------------- Transverse fractures of the spinous process of the 7th cervical vertebra in RDT patients: an Al related disease? From: Int J Artif Organs (1987 Mar) 10(2):93-6 The bone fractures had occurred suddenly while the patients were going about their daily work. These observations indicate that Al- or iron- related bone disease with secondary hyperparathyroidism can induce bone fracture by only slight stress in patients maintained on hemodialysis. -------------------------------------------------------------------------------- Risk of aluminum accumulation in patients with burns and ways to reduce it. Klein G.L. – Herndon D.N. – Rutan T.C. – Barnett J.R. – Miller N.L. – Alfrey A.C. From: J Burn Care Rehabil (1994 Jul-Aug) 15(4):354-8 Severely burned patients experience a bone lesion consisting of markedly reduced bone formation and evidence of decreased resportion. The cause of the lesion may be multifactorial, but aluminum loading, which also occurs in patients with burns, has been documented to produce this type of injury in both humans and animals. Cutaneous exposure to aluminum is greatest from baths, which may provide up to 8 mg aluminum. However, the dynamics of aluminum entry into the blood via a damaged skin barrier are unclear. Enteral exposure to aluminum is no greater than daily dietary exposure. Parenteral sources of aluminum, especially 25% human serum albumin and calcium gluconate, provide the most significant risk of loading because of direct introduction of aluminum into the circulation. Substitution with a different brand of albumin and calcium chloride can reduce the parenteral aluminum load by as much as 95% and minimize any role aluminum may play in the pathogenesis of this bone lesion. -------------------------------------------------------------------------------- Aluminum concentrations in tissues of rats: effect of soft drink packaging. Kandiah J. – Kies C. From: Biometals (1994 Jan) 7(1):57-60 Canned soft drink fed rats had significantly higher blood, liver and bone aluminum concentration than rats that were given glass bottled soft drink. Sources of Aluminum Over the Counter; Deoderants, vaginal douches, baby wipes, skin creams, suntan lotions, toothpaste, buffered asprin, some haemorrhoid and diarrhea products. Medical; Vaccinations, allergy testing, intervenous solutions, allergens, wound and antacid irrigation, ulcer treatment, blood oxygenization, bone or joint replacement and burn treatment. Foods; Aluminum cans, foils, containers, baking powder, cake mixes, frozen dough, pancake mixes, self-rising flour, grains, processed cheese. Environmental Effects of Aluminum -------------------------------------------------------------------------------- CT Aluminum in acidic surface waters: chemistry, transport, and effects. From: Environ Health Perspect (1985 Nov) 63:93-104 Ecologically significant concentrations of Al have been reported in surface waters draining "acid-sensitive" watersheds that are receiving elevated inputs of acidic deposition. It has been hypothesized that mineral acids from atmospheric deposition have remobilized Al previously precipitated within the soil during soil development. This Al is then thought to be transported to adjacent surface waters. Dissolved mononuclear Al occurs as aquo Al, as well as OH-, F-, SO4(2-), and organic complexes. Although past investigations have often ignored non-hydroxide complexes of Al, it appears that organic and F complexes are the predominant forms of Al in dilute (low ionic strength) acidic surface waters. The concentration of inorganic forms of Al increases exponentially with decreases in solution pH. This response is similar to the theoretical pH dependent solubility of Al mineral phases. The concentration of organic forms of Al, however, is strongly correlated with variations in organic carbon concentration of surface waters rather than pH. Elevated concentrations of Al in dilute acidic waters are of interest because: Al is an important pH buffer; Al may influence the cycling of important elements like P, organic carbon, and trace metals; and Al is potentially toxic to aquatic organisms. -------------------------------------------------------------------------------- Inhibition of Ca2+ uptake in freshwater carp, Cyprinus carpio, during short-term exposure to aluminum. Verbost P.M. – Lafeber F.P. – Spanings F.A. – Aarden E.M. – Wendelaar Bonga S.E. From: J Exp Zool (1992 Jun 1) 262(3):247-54 In carp exposed to pH 5.2 in fresh water, the Ca2+ influx from the water is reduced by 31% when compared to fish in water of neutral pH. At pH 5.2, the Ca2+ influx but not Na+ uptake is decreased by aluminum (Al). Al reduces Ca2+ influx dose-dependently: a maximum 55% reduction was observed after 1-2 h exposure to 200 micrograms .1(-1) (7.4 microM) Al. -------------------------------------------------------------------------------- A mechanism for acute aluminium toxicity in fish Exley C. – Chappell J.S. – Birchall J.D. From: J Theor Biol (1991 Aug 7) 151(3):417-28 Aluminium is acutely toxic to fish in acid waters. The gill is the principal target organ and death is due to a combination of ionoregulatory, osmoregulatory and respiratory dysfunction. The mechanism of epithelial cell death is proposed as a general mechanism of aluminium-induced accelerated cell death. -------------------------------------------------------------------------------- Can the mechanisms of aluminum neurotoxicity be integrated into a unified scheme? Strong M.J. – Garruto R.M. – Joshi J.G. – Mundy W.R. – Shafer T.J. From: J Toxicol Environ Health (1996 Aug 30) 48(6):599-613 Regardless of the host, the route of administration, or the speciation, aluminum is a potent neurotoxicant. In the young adult or developmentally mature host, the neuronal response to Al exposure can be dichotomized on morphological grounds. In one, intraneuronal neurofilamentous aggregates are formed, whereas in the other, significant neurochemical and neurophysiological perturbations are induced without neurofilamentous aggregate formation. Evidence is presented that the induction of neurofilamentous aggregates is a consequence of alterations in the posttranslational processing of neurofilament (NF), particularly with regard to phosphorylation state. Although Al has been reported to impact on gene expression, this does not appear to be critical to the induction of cytoskeletal pathology. In hosts responding to Al exposure without the induction of cytoskeletal pathology, impairments in glucose utilization, agonist-stimulated inositol phosphate accumulation, free radical-mediated cytotoxicity, lipid peroxidation, reduced cholinergic function, and altered protein phosphorylation have been described. The extent to which these neurochemical modifications correlate with the induction of a characteristic neurobehavioral state is unknown. In addition to these paradigms, Al is toxic in the immediate postnatal interval. Whether unique mechanisms of toxicity are involved during development remains to be determined. In this article, the mechanisms of Al neurotoxicity are reviewed and recommendations are put forth with regard to future research. Institutional address: Department of Clinical Neurological Sciences University of Western Ontario London, Canada. -------------------------------------------------------------------------------- Aluminum toxicity following intravesical alum irrigation for hemorrhagic cystitis. Kanwar V.S. – Jenkins J.J. 3rd – Mandrell B.N. – Furman W.L. From: Med Pediatr Oncol (1996 Jul) 27(1):64-7 Mental status changes in an immunosuppressed child can be due to a variety of causes; aluminum toxicity is rarely considered. We report a teenage girl with acute lymphoblastic leukemia who developed mental status changes, speech disturbance, coarse tremor, and abnormal EEG findings following intravesical 1% alum irrigation and administration of aluminum-containing antacids. All abnormalities resolved after a nine-week course of intravenous deferoxamine. -------------------------------------------------------------------------------- Progressing encephalomyelopathy with muscular atrophy, induced by aluminum powder. Bugiani O. – Ghetti B. From: Neurobiol Aging (1982 Fall) 3(3):209-22 The injection of aluminum powder into the cerebrospinal fluid of adult rabbits induced a slowly progressing encephalomyelopathy characterized at first by alteration of posture and then by myoclonic jerks and muscle weakness. Neurofibrillary degeneration was the hallmark of the disease and involved most of the gray areas. Neurogenic muscular atrophy appeared in animals sacrificed in the second and third month after injection. -------------------------------------------------------------------------------- Aluminium foil as a wound dressing Poole M.D. – Kalus A.M. – von Domarus H. From: Br J Plast Surg (1979 Apr) 32(2):145-6 ISBN: 0007-1226 Aluminium foil has been found to be an extremely useful and painless way of dressing wounds prior to delayed skin grafting. However, it is not recommended for use on skin-graft donor sites as it delays epithelial healing. -------------------------------------------------------------------------------- From: History of crime against the Food Laws (1929) by Dr. Riley, the prime mover behind the original Pure Food Law and Director of the FDA. He resigned in disgust in 1912 over exceptions granted to the law and lack of enforcement. Aluminum has been exempted from testing for safety by the FDA under a convoluted logic wherein it is classified as GRAS. (Generally Regarded As Safe.) It has never been tested by the FDA on its safety and there are NO restrictions whatever on the amount or use of aluminum. Diseases Associated with Aluminium Intoxication H. Tomlinson, M.B., Ch.B., MRCS., LRCP -------------------------------------------------------------------------------- Aluminum is known to inhibit cell division during the "S Phase" at levels less than 4 ppm. Aluminum toxicity is a widespread problem in all forms of life, including humans, animals, fish, plants and trees, and causes widespread degradation of the environment and health. Over 7,000 reference articles on aluminum toxicity existed in various data bases as of 1936, (Today, there are more than a million.) all recognizing the toxicity. |
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