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ABC propaganda on aspartame
Subj: Dr. Karl on your ABC web site who put outs propaganda on
aspartame instead of facts of its absolute known toxicity Date: 9/5/04 10:19:31 PM Eastern Daylight Time From: (Dr. Betty Martini) To: (ABC CORPORATE_AFFAIRS5) Dear Kieran Doyle: How can you make such a statement. Is the aspartame industry giving you advertising money? The toxicity of aspartame has been proven beyond any shadow of a doubt. There are four support groups on line just taking care of the sick and disabled on this neurotoxin. There are numerous medical texts on the toxicity of aspartame: www.sunsentpress.com H. J. Roberts, M.D. This includes the medical text, Aspartame Disease: An Ignored Epidemic - 1038 pages of diseases and symptoms triggered by this neurotoxin. www.russellblaylockmd.com Russell Blaylock, M.D., Excitotoxins: The Taste That Kills about this neurotoxin Aspartame Detoxification Centers in the US, Canada and Brazil Mission Possible Operations in 50 states and 22 countries of the world warning consumers of this poison. A quarter of a million web sites with articles on the toxicity 92 per cent of independent, peer reviewed scientific studies showing the problems aspartame causes (See Dr. Walton's report on www.dorway.com on this research which he showed on 60 Minutes) Lawsuits filed against 14 of the largest companies in the world for poisoning the public on aspartame knowingly - www.wnho.net also click on aspartame FDA records showing including a Board of Inquiry report showing the asked that aspartame not be approved. (Donald Rumsfeld called in his markers to get it approved. Dr. Hayes over-ruled the Board of Inquiry. Rumsfeld was on President Reagan's transition team. After he appointed Dr. Hayes because no FDA Commissioner would allow it on the market for 16 years, he was so afraid he wouldn't get to the FDA in time before the current Commissioner put a stop to approval, he wrote an executive order making this Commissioner powerless. What clout!) FDA had also asked for the indictment of the manufacturer but both US Prosecutors hired on with the defense team and the statute of limitations expired. Your Dr. Karl is talking about when I lectured for the World Environmental Conference and my invitation to speak is on www.dorway.com/nomarkle.html So since there is proof and the medical text lists all the diseases I lectured on how can you look at the evidence and say it doesn't exist. Even a new movie, Sweet Misery: A Poisoned World ) has just been made with the world experts telling the true story of aspartame and its toxicity with proven research. Two other movies are in the making exposing this global plague. Now either explain why you say no evidence of toxicity exists when we have given you that evidence, or be assured this information will be put all over the Internet. I'm ashamed of ABC for allowing misinformation to stumble the public. I see you are in Australia, and Sandra Cabot, M.D., is Mission Possible Australia and lectures all over the world on the toxicity of aspartame. You can contact her at or One of the two is valid. I'm shocked to see this misinformation continued as if the evidence wasn't provided. Shame on ABC. I would like to know who is the President and his email address. Dr. Betty Martini, Founder, Mission Possible International, 9270 River Club Parkway, Duluth, Georgia 30097 770 242-2599 www.dorway.com and www.wnho.net (warning the world off aspartame) At 09:53 PM 9/5/2004, ABC CORPORATE_AFFAIRS5 wrote: Dear Dr Martini Thank you for your email of 8 August 2004. The ABC has investigated your concerns and reviewed the content of the journals and websites referenced in your email. However, the ABC cannot agree that Dr Karl has misinformed its audience. Having comprehensively reviewed your literature and Dr Karl's original references, the ABC believes that no medical evidence has been presented to support the claims about the toxicity of the substance. Nevertheless, please be assured that your views have been noted. Your sincerely Kieran Doyle ABC Audience and Consumer Affairs Below is the result of your feedback form. It was submitted by Dr. Betty Martini ) on Sunday, August 08, 2004 at 05:21:33 --------------------------------------------------------------------------- From: http://www.abc.net.au/contact/ locationS: Outside Australia program: Dr. Karl on your ABC web site comments: The Dr. Karl on the web site is giving out misinformation. I'm the one who lectured for the World Environmental Conference and everything I lectured on has been documented in the medical text on the global plague of Aspartame Disease: Aspartame Disease: An Ignored Epidemic, www.sunsentpress.com by world expert H. J. Roberts, M.D. Lawsuits have already been filed against some of the largest companies in the world for poisoning the public on the subject. Here is one of my posts I would appreciate you adding to your web site to counteract Dr. Karl's misinformation. Please reply to me. Dr. Betty Martini, ASPARTAME: NO HOAX, CRIME OF THE CENTURY (FRONT GROUPS IN VIOLATION OF TITLE 18, SECTION 1001 WHEN THEY LIE ABOUT THE ASPARTAME ISSUE AND STUMBLE OTHERS) By Dr. Betty Martini Mission Possible International 9270 River Club Parkway Duluth, Georgia 30097 Telephone: 770-242-2599 E-Mail: Web Site: http://www.dorway.com 18 July 2004 This is in repose to the posting that aspartame being harmful is nothing more than a hoax at: http://www.snopes.com/toxins/aspartame.asp Dear Whoever you are who doesn't want to sign their name: First of all, I'm Dr. Betty Martini, Founder of Mission Possible International, a worldwide volunteer force in 50 states and over 22 countries of the world getting information from world experts on aspartame to the general public to alert them of the dangers. Who are you who goes to "front groups" to get information. Snoops and Urban Legends are in violation of Title 18, Section 1001 of the Criminal Code for stumbling the people. Obviously, we've sent them my invitation to speak for the World Environmental Conference, and confirmation by Dr. Clarice Gaylord that I did speak, who is with the EPA and gave the keynote address. That information is on http://www.dorway.com/nomarkle.html Secondly, its all a mute point since H. J. Roberts, M.D. has declared Aspartame Disease to be a global plague and published the medical text, Aspartame Disease: An Ignored Epidemic, http://www.sunsentpress.com or 1-800-827-7991. This 1038 page medical text documents everything I lectured on from MS and lupus to diabetes and brain tumors. Not only that but its even documented in a new movie, Sweet Misery: A Poisoned World. You can get a copy from Sound And Fury Productions ) It has the world experts on aspartame in it, Doctors Roberts, Blaylock, Walton, Olney, Bowen and even a former FDA Investigator, Arthur Evangelista explaining how deadly aspartame is. Furthermore, suit have now been filed against some of the world's largest companies for poisoning the public with aspartame including Coke, Pepsi, Slimfast, Atria - General Foods, Walmart, Bayer, etc., etc. Read it all on http://www.wnho.net Also, Dr. Blaylock, a neurosurgeon, just released a paper on the MS and Aspartame connection with new research. I'll send it to you. And here is a note from Ed Johnson to Snoops and Urban Legends who worked for the Justice Department. I don't know whether you're just someone who is ignorant and didn't realize there are people who take money to lie. These guys have been told for years and sent all confirming information. In fact, a new book just recently came out by Michael Barbee that exposes this. It's called Politically Incorrect Nutrition. Regarding this issue, and on page 49 it says: "Betty Martini is an aspartame activist. She created quite a stir in l995 when a letter she wrote, based on her talks at the World Environmental Conference that year, found it way to the Internet as the "Nancy Markle" letter. It was widely circulated and shocked the world. She clearly laid out the dangers of aspartame consumption and showed how government and corporate interests put profits ahead of public health." ."She was attacked, however, by some who felt the information belonged to the category of "urban legend" or "urban rumor." One prominent critic said that she left too many unanswered questions. When Ms. Martini answered those questions, her critic refused to put them on his web site." "Another so-called "exposer of junk science" who tried to discredit her position over the Internet was, in fact, a former lobbyist for the tobacco industry and directed an organization created by Philip Morris to attack the EPA's position on second-hand smoke. He and other shills working for industry front-groups have formed much of Ms. Martini's opposition." So you see, they didn't get away with it. They have all been exposed now and I'm surprised you didn't know or are you somebody who just wanted to see what we send out when somebody has read their lies? You notice I'm sending them a copy of those notes. Did you know there is a name for those "who do it for money"! Since my lecturing for the World Environmental Conference has been confirmed why would one call it a hoax unless they were paid to do so? But I'm glad to get those notes so I can refer them again to the Justice Department where they have been reported many times for being in violation of Title 18, Section 1001. Personally, I have no respect for those who lie. And below is what we send out when people are lied to. I'll send you separately, the new paper on the MS and Aspartame connection with current research substantiating the issue. The Idaho Observer has put out 24 page booklets for distributing on Aspartame Disease, although they have changed the name to Rumsfeld Disease, since he got it approved with a lot of politics when the FDA said to revoke the petition for approval. Get the movie and find out just how far he went. The reason Snoops and Urban Legends have failed is that my number is all over the Internet and web sites so anything can call and get the facts. And we have all the documentation. Be sure to also check the Aspartame Toxicity Center, http://www.holisticmed.com/aspartame Dr. Betty Martini Founder, Mission Possible International 9270 River Club Parkway Duluth, Georgia 30097 770-242-2599 http://www.dorway.com http://www.whno.net |
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"john" wrote in message ... Subj: Dr. Karl on your ABC web site who put outs propaganda on aspartame instead of facts of its absolute known toxicity Date: 9/5/04 10:19:31 PM Eastern Daylight Time From: (Dr. Betty Martini) That is deceptive. Betty Martini ihas an honorary doctoratre from an unaccredited Bible college. In no way does it confer any special expertise on her. To: (ABC CORPORATE_AFFAIRS5) Dear Kieran Doyle: How can you make such a statement. Is the aspartame industry giving you advertising money? The toxicity of aspartame has been proven beyond any shadow of a doubt. There are four support groups on line just taking care of the sick and disabled on this neurotoxin. There are numerous medical texts on the toxicity of aspartame: www.sunsentpress.com H. J. Roberts, M.D. This includes the medical text, Aspartame Disease: An Ignored Epidemic - 1038 pages of diseases and symptoms triggered by this neurotoxin. www.russellblaylockmd.com Russell Blaylock, M.D., Excitotoxins: The Taste That Kills about this neurotoxin Aspartame Detoxification Centers in the US, Canada and Brazil Mission Possible Operations in 50 states and 22 countries of the world warning consumers of this poison. A quarter of a million web sites with articles on the toxicity 92 per cent of independent, peer reviewed scientific studies showing the problems aspartame causes (See Dr. Walton's report on www.dorway.com on this research which he showed on 60 Minutes) Lawsuits filed against 14 of the largest companies in the world for poisoning the public on aspartame knowingly - www.wnho.net also click on aspartame FDA records showing including a Board of Inquiry report showing the asked that aspartame not be approved. (Donald Rumsfeld called in his markers to get it approved. Dr. Hayes over-ruled the Board of Inquiry. Rumsfeld was on President Reagan's transition team. After he appointed Dr. Hayes because no FDA Commissioner would allow it on the market for 16 years, he was so afraid he wouldn't get to the FDA in time before the current Commissioner put a stop to approval, he wrote an executive order making this Commissioner powerless. What clout!) FDA had also asked for the indictment of the manufacturer but both US Prosecutors hired on with the defense team and the statute of limitations expired. Your Dr. Karl is talking about when I lectured for the World Environmental Conference and my invitation to speak is on www.dorway.com/nomarkle.html So since there is proof and the medical text lists all the diseases I lectured on how can you look at the evidence and say it doesn't exist. Even a new movie, Sweet Misery: A Poisoned World ) has just been made with the world experts telling the true story of aspartame and its toxicity with proven research. Two other movies are in the making exposing this global plague. Now either explain why you say no evidence of toxicity exists when we have given you that evidence, or be assured this information will be put all over the Internet. I'm ashamed of ABC for allowing misinformation to stumble the public. I see you are in Australia, and Sandra Cabot, M.D., is Mission Possible Australia and lectures all over the world on the toxicity of aspartame. You can contact her at or One of the two is valid. I'm shocked to see this misinformation continued as if the evidence wasn't provided. Shame on ABC. I would like to know who is the President and his email address. Dr. Betty Martini, Founder, Mission Possible International, 9270 River Club Parkway, Duluth, Georgia 30097 770 242-2599 www.dorway.com and www.wnho.net (warning the world off aspartame) At 09:53 PM 9/5/2004, ABC CORPORATE_AFFAIRS5 wrote: Dear Dr Martini Thank you for your email of 8 August 2004. The ABC has investigated your concerns and reviewed the content of the journals and websites referenced in your email. However, the ABC cannot agree that Dr Karl has misinformed its audience. Having comprehensively reviewed your literature and Dr Karl's original references, the ABC believes that no medical evidence has been presented to support the claims about the toxicity of the substance. Nevertheless, please be assured that your views have been noted. Your sincerely Kieran Doyle ABC Audience and Consumer Affairs Below is the result of your feedback form. It was submitted by Dr. Betty Martini ) on Sunday, August 08, 2004 at 05:21:33 --------------------------------------------------------------------------- From: http://www.abc.net.au/contact/ locationS: Outside Australia program: Dr. Karl on your ABC web site comments: The Dr. Karl on the web site is giving out misinformation. I'm the one who lectured for the World Environmental Conference and everything I lectured on has been documented in the medical text on the global plague of Aspartame Disease: Aspartame Disease: An Ignored Epidemic, www.sunsentpress.com by world expert H. J. Roberts, M.D. Lawsuits have already been filed against some of the largest companies in the world for poisoning the public on the subject. Here is one of my posts I would appreciate you adding to your web site to counteract Dr. Karl's misinformation. Please reply to me. Dr. Betty Martini, ASPARTAME: NO HOAX, CRIME OF THE CENTURY (FRONT GROUPS IN VIOLATION OF TITLE 18, SECTION 1001 WHEN THEY LIE ABOUT THE ASPARTAME ISSUE AND STUMBLE OTHERS) By Dr. Betty Martini Mission Possible International 9270 River Club Parkway Duluth, Georgia 30097 Telephone: 770-242-2599 E-Mail: Web Site: http://www.dorway.com 18 July 2004 This is in repose to the posting that aspartame being harmful is nothing more than a hoax at: http://www.snopes.com/toxins/aspartame.asp Dear Whoever you are who doesn't want to sign their name: First of all, I'm Dr. Betty Martini, Founder of Mission Possible International, a worldwide volunteer force in 50 states and over 22 countries of the world getting information from world experts on aspartame to the general public to alert them of the dangers. Who are you who goes to "front groups" to get information. Snoops and Urban Legends are in violation of Title 18, Section 1001 of the Criminal Code for stumbling the people. Obviously, we've sent them my invitation to speak for the World Environmental Conference, and confirmation by Dr. Clarice Gaylord that I did speak, who is with the EPA and gave the keynote address. That information is on http://www.dorway.com/nomarkle.html Secondly, its all a mute point since H. J. Roberts, M.D. has declared Aspartame Disease to be a global plague and published the medical text, Aspartame Disease: An Ignored Epidemic, http://www.sunsentpress.com or 1-800-827-7991. This 1038 page medical text documents everything I lectured on from MS and lupus to diabetes and brain tumors. Not only that but its even documented in a new movie, Sweet Misery: A Poisoned World. You can get a copy from Sound And Fury Productions ) It has the world experts on aspartame in it, Doctors Roberts, Blaylock, Walton, Olney, Bowen and even a former FDA Investigator, Arthur Evangelista explaining how deadly aspartame is. Furthermore, suit have now been filed against some of the world's largest companies for poisoning the public with aspartame including Coke, Pepsi, Slimfast, Atria - General Foods, Walmart, Bayer, etc., etc. Read it all on http://www.wnho.net Also, Dr. Blaylock, a neurosurgeon, just released a paper on the MS and Aspartame connection with new research. I'll send it to you. And here is a note from Ed Johnson to Snoops and Urban Legends who worked for the Justice Department. I don't know whether you're just someone who is ignorant and didn't realize there are people who take money to lie. These guys have been told for years and sent all confirming information. In fact, a new book just recently came out by Michael Barbee that exposes this. It's called Politically Incorrect Nutrition. Regarding this issue, and on page 49 it says: "Betty Martini is an aspartame activist. She created quite a stir in l995 when a letter she wrote, based on her talks at the World Environmental Conference that year, found it way to the Internet as the "Nancy Markle" letter. It was widely circulated and shocked the world. She clearly laid out the dangers of aspartame consumption and showed how government and corporate interests put profits ahead of public health." ."She was attacked, however, by some who felt the information belonged to the category of "urban legend" or "urban rumor." One prominent critic said that she left too many unanswered questions. When Ms. Martini answered those questions, her critic refused to put them on his web site." "Another so-called "exposer of junk science" who tried to discredit her position over the Internet was, in fact, a former lobbyist for the tobacco industry and directed an organization created by Philip Morris to attack the EPA's position on second-hand smoke. He and other shills working for industry front-groups have formed much of Ms. Martini's opposition." So you see, they didn't get away with it. They have all been exposed now and I'm surprised you didn't know or are you somebody who just wanted to see what we send out when somebody has read their lies? You notice I'm sending them a copy of those notes. Did you know there is a name for those "who do it for money"! Since my lecturing for the World Environmental Conference has been confirmed why would one call it a hoax unless they were paid to do so? But I'm glad to get those notes so I can refer them again to the Justice Department where they have been reported many times for being in violation of Title 18, Section 1001. Personally, I have no respect for those who lie. And below is what we send out when people are lied to. I'll send you separately, the new paper on the MS and Aspartame connection with current research substantiating the issue. The Idaho Observer has put out 24 page booklets for distributing on Aspartame Disease, although they have changed the name to Rumsfeld Disease, since he got it approved with a lot of politics when the FDA said to revoke the petition for approval. Get the movie and find out just how far he went. The reason Snoops and Urban Legends have failed is that my number is all over the Internet and web sites so anything can call and get the facts. And we have all the documentation. Be sure to also check the Aspartame Toxicity Center, http://www.holisticmed.com/aspartame Dr. Betty Martini Founder, Mission Possible International 9270 River Club Parkway Duluth, Georgia 30097 770-242-2599 http://www.dorway.com http://www.whno.net |
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My email to Mr. Doyle: Dear Mr. Doyle I have copied, below, an email that was allegedly sent to you from a person calling herself "Dr. Betty Martini" a well known inter loon. Ms. Martini's "doctorate" was issued by an unaccredited Boble college in the United States and does not confer on her the imprimatur of knowledge. Allow me to take this opportunity to suggest a program on Internet Loons, Nuts and Scams. It could run over sever nights, as their are so many. Mark Probert "john" wrote in message ... Subj: Dr. Karl on your ABC web site who put outs propaganda on aspartame instead of facts of its absolute known toxicity Date: 9/5/04 10:19:31 PM Eastern Daylight Time From: (Dr. Betty Martini) To: (ABC CORPORATE_AFFAIRS5) Dear Kieran Doyle: How can you make such a statement. Is the aspartame industry giving you advertising money? The toxicity of aspartame has been proven beyond any shadow of a doubt. There are four support groups on line just taking care of the sick and disabled on this neurotoxin. There are numerous medical texts on the toxicity of aspartame: www.sunsentpress.com H. J. Roberts, M.D. This includes the medical text, Aspartame Disease: An Ignored Epidemic - 1038 pages of diseases and symptoms triggered by this neurotoxin. www.russellblaylockmd.com Russell Blaylock, M.D., Excitotoxins: The Taste That Kills about this neurotoxin Aspartame Detoxification Centers in the US, Canada and Brazil Mission Possible Operations in 50 states and 22 countries of the world warning consumers of this poison. A quarter of a million web sites with articles on the toxicity 92 per cent of independent, peer reviewed scientific studies showing the problems aspartame causes (See Dr. Walton's report on www.dorway.com on this research which he showed on 60 Minutes) Lawsuits filed against 14 of the largest companies in the world for poisoning the public on aspartame knowingly - www.wnho.net also click on aspartame FDA records showing including a Board of Inquiry report showing the asked that aspartame not be approved. (Donald Rumsfeld called in his markers to get it approved. Dr. Hayes over-ruled the Board of Inquiry. Rumsfeld was on President Reagan's transition team. After he appointed Dr. Hayes because no FDA Commissioner would allow it on the market for 16 years, he was so afraid he wouldn't get to the FDA in time before the current Commissioner put a stop to approval, he wrote an executive order making this Commissioner powerless. What clout!) FDA had also asked for the indictment of the manufacturer but both US Prosecutors hired on with the defense team and the statute of limitations expired. Your Dr. Karl is talking about when I lectured for the World Environmental Conference and my invitation to speak is on www.dorway.com/nomarkle.html So since there is proof and the medical text lists all the diseases I lectured on how can you look at the evidence and say it doesn't exist. Even a new movie, Sweet Misery: A Poisoned World ) has just been made with the world experts telling the true story of aspartame and its toxicity with proven research. Two other movies are in the making exposing this global plague. Now either explain why you say no evidence of toxicity exists when we have given you that evidence, or be assured this information will be put all over the Internet. I'm ashamed of ABC for allowing misinformation to stumble the public. I see you are in Australia, and Sandra Cabot, M.D., is Mission Possible Australia and lectures all over the world on the toxicity of aspartame. You can contact her at or One of the two is valid. I'm shocked to see this misinformation continued as if the evidence wasn't provided. Shame on ABC. I would like to know who is the President and his email address. Dr. Betty Martini, Founder, Mission Possible International, 9270 River Club Parkway, Duluth, Georgia 30097 770 242-2599 www.dorway.com and www.wnho.net (warning the world off aspartame) At 09:53 PM 9/5/2004, ABC CORPORATE_AFFAIRS5 wrote: Dear Dr Martini Thank you for your email of 8 August 2004. The ABC has investigated your concerns and reviewed the content of the journals and websites referenced in your email. However, the ABC cannot agree that Dr Karl has misinformed its audience. Having comprehensively reviewed your literature and Dr Karl's original references, the ABC believes that no medical evidence has been presented to support the claims about the toxicity of the substance. Nevertheless, please be assured that your views have been noted. Your sincerely Kieran Doyle ABC Audience and Consumer Affairs Below is the result of your feedback form. It was submitted by Dr. Betty Martini ) on Sunday, August 08, 2004 at 05:21:33 --------------------------------------------------------------------------- From: http://www.abc.net.au/contact/ locationS: Outside Australia program: Dr. Karl on your ABC web site comments: The Dr. Karl on the web site is giving out misinformation. I'm the one who lectured for the World Environmental Conference and everything I lectured on has been documented in the medical text on the global plague of Aspartame Disease: Aspartame Disease: An Ignored Epidemic, www.sunsentpress.com by world expert H. J. Roberts, M.D. Lawsuits have already been filed against some of the largest companies in the world for poisoning the public on the subject. Here is one of my posts I would appreciate you adding to your web site to counteract Dr. Karl's misinformation. Please reply to me. Dr. Betty Martini, ASPARTAME: NO HOAX, CRIME OF THE CENTURY (FRONT GROUPS IN VIOLATION OF TITLE 18, SECTION 1001 WHEN THEY LIE ABOUT THE ASPARTAME ISSUE AND STUMBLE OTHERS) By Dr. Betty Martini Mission Possible International 9270 River Club Parkway Duluth, Georgia 30097 Telephone: 770-242-2599 E-Mail: Web Site: http://www.dorway.com 18 July 2004 This is in repose to the posting that aspartame being harmful is nothing more than a hoax at: http://www.snopes.com/toxins/aspartame.asp Dear Whoever you are who doesn't want to sign their name: First of all, I'm Dr. Betty Martini, Founder of Mission Possible International, a worldwide volunteer force in 50 states and over 22 countries of the world getting information from world experts on aspartame to the general public to alert them of the dangers. Who are you who goes to "front groups" to get information. Snoops and Urban Legends are in violation of Title 18, Section 1001 of the Criminal Code for stumbling the people. Obviously, we've sent them my invitation to speak for the World Environmental Conference, and confirmation by Dr. Clarice Gaylord that I did speak, who is with the EPA and gave the keynote address. That information is on http://www.dorway.com/nomarkle.html Secondly, its all a mute point since H. J. Roberts, M.D. has declared Aspartame Disease to be a global plague and published the medical text, Aspartame Disease: An Ignored Epidemic, http://www.sunsentpress.com or 1-800-827-7991. This 1038 page medical text documents everything I lectured on from MS and lupus to diabetes and brain tumors. Not only that but its even documented in a new movie, Sweet Misery: A Poisoned World. You can get a copy from Sound And Fury Productions ) It has the world experts on aspartame in it, Doctors Roberts, Blaylock, Walton, Olney, Bowen and even a former FDA Investigator, Arthur Evangelista explaining how deadly aspartame is. Furthermore, suit have now been filed against some of the world's largest companies for poisoning the public with aspartame including Coke, Pepsi, Slimfast, Atria - General Foods, Walmart, Bayer, etc., etc. Read it all on http://www.wnho.net Also, Dr. Blaylock, a neurosurgeon, just released a paper on the MS and Aspartame connection with new research. I'll send it to you. And here is a note from Ed Johnson to Snoops and Urban Legends who worked for the Justice Department. I don't know whether you're just someone who is ignorant and didn't realize there are people who take money to lie. These guys have been told for years and sent all confirming information. In fact, a new book just recently came out by Michael Barbee that exposes this. It's called Politically Incorrect Nutrition. Regarding this issue, and on page 49 it says: "Betty Martini is an aspartame activist. She created quite a stir in l995 when a letter she wrote, based on her talks at the World Environmental Conference that year, found it way to the Internet as the "Nancy Markle" letter. It was widely circulated and shocked the world. She clearly laid out the dangers of aspartame consumption and showed how government and corporate interests put profits ahead of public health." ."She was attacked, however, by some who felt the information belonged to the category of "urban legend" or "urban rumor." One prominent critic said that she left too many unanswered questions. When Ms. Martini answered those questions, her critic refused to put them on his web site." "Another so-called "exposer of junk science" who tried to discredit her position over the Internet was, in fact, a former lobbyist for the tobacco industry and directed an organization created by Philip Morris to attack the EPA's position on second-hand smoke. He and other shills working for industry front-groups have formed much of Ms. Martini's opposition." So you see, they didn't get away with it. They have all been exposed now and I'm surprised you didn't know or are you somebody who just wanted to see what we send out when somebody has read their lies? You notice I'm sending them a copy of those notes. Did you know there is a name for those "who do it for money"! Since my lecturing for the World Environmental Conference has been confirmed why would one call it a hoax unless they were paid to do so? But I'm glad to get those notes so I can refer them again to the Justice Department where they have been reported many times for being in violation of Title 18, Section 1001. Personally, I have no respect for those who lie. And below is what we send out when people are lied to. I'll send you separately, the new paper on the MS and Aspartame connection with current research substantiating the issue. The Idaho Observer has put out 24 page booklets for distributing on Aspartame Disease, although they have changed the name to Rumsfeld Disease, since he got it approved with a lot of politics when the FDA said to revoke the petition for approval. Get the movie and find out just how far he went. The reason Snoops and Urban Legends have failed is that my number is all over the Internet and web sites so anything can call and get the facts. And we have all the documentation. Be sure to also check the Aspartame Toxicity Center, http://www.holisticmed.com/aspartame Dr. Betty Martini Founder, Mission Possible International 9270 River Club Parkway Duluth, Georgia 30097 770-242-2599 http://www.dorway.com http://www.whno.net |
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"john" wrote in message ... Subj: Dr. Karl on your ABC web site who put outs propaganda on aspartame instead of facts of its absolute known toxicity Date: 9/5/04 10:19:31 PM Eastern Daylight Time From: (Dr. Betty Martini) To: (ABC CORPORATE_AFFAIRS5) Dear Kieran Doyle: How can you make such a statement. Is the aspartame industry giving you advertising money? The toxicity of aspartame has been proven beyond any shadow of a doubt. True. The toxicity has been proven to be nill. There are four support groups on line just taking care of the sick and disabled on this neurotoxin. Incorrect. There are four support groups online to give people who are sick and disable something to focus their energies on, regardless of whether or not aspartame is toxic. It isn't. There are numerous medical texts on the toxicity of aspartame: No, there are two books written by assholes and published by vanity presses. www.sunsentpress.com H. J. Roberts, M.D. This includes the medical text, Aspartame Disease: An Ignored Epidemic - 1038 pages of diseases and symptoms triggered by this neurotoxin. www.russellblaylockmd.com Russell Blaylock, M.D., Excitotoxins: The Taste That Kills about this neurotoxin Aspartame Detoxification Centers in the US, Canada and Brazil Mission Possible Operations in 50 states and 22 countries of the world warning consumers of this poison. This should be called mission stupid. Because aspartame is not toxic. A quarter of a million web sites with articles on the toxicity Stupidity in numbers is still stupidity. 92 per cent of independent, peer reviewed scientific studies showing the problems aspartame causes (See Dr. Walton's report on www.dorway.com on this research which he showed on 60 Minutes) The Dorway. com site is amongst the stupist on the internet. Lawsuits filed against 14 of the largest companies in the world for poisoning the public on aspartame knowingly - www.wnho.net also click on aspartame so what? Lawsuits are about getting money from deep pockets, not the truth. FDA records showing including a Board of Inquiry report showing the asked that aspartame not be approved. (Donald Rumsfeld called in his markers to get it approved. Dr. Hayes over-ruled the Board of Inquiry. Rumsfeld was on President Reagan's transition team. After he appointed Dr. Hayes because no FDA Commissioner would allow it on the market for 16 years, he was so afraid he wouldn't get to the FDA in time before the current Commissioner put a stop to approval, he wrote an executive order making this Commissioner powerless. What clout!) FDA had also asked for the indictment of the manufacturer but both US Prosecutors hired on with the defense team and the statute of limitations expired. Your Dr. Karl is talking about when I lectured for the World Environmental Conference and my invitation to speak is on www.dorway.com/nomarkle.html So since there is proof and the medical text lists all the diseases I lectured on how can you look at the evidence and say it doesn't exist. The evidence exists. It is unrealiable and of poor quality. The person who is showing us this is evidence is an asshole. Even a new movie, Sweet Misery: A Poisoned World ) has just been made with the world experts telling the true story of aspartame and its toxicity with proven research. Two other movies are in the making exposing this global plague. The real global plagues are ignorance and obesity. Now either explain why you say no evidence of toxicity exists when we have given you that evidence, or be assured this information will be put all over the Internet. I'm ashamed of ABC for allowing misinformation to stumble the public. I am proud of ABC for telling the truth. I see you are in Australia, and Sandra Cabot, M.D., is Mission Possible Australia and lectures all over the world on the toxicity of aspartame. You can contact her at or One of the two is valid. They are gullible in australia, too. I'm shocked to see this misinformation continued as if the evidence wasn't provided. Shame on ABC. I would like to know who is the President and his email address. Yes, I am shocked too. Ms Martini (with the mail order doctorate) is still throwing this **** around. Dr. Betty Martini, Founder, Mission Possible International, 9270 River Club Parkway, Duluth, Georgia 30097 770 242-2599 www.dorway.com and www.wnho.net (warning the world off aspartame) At 09:53 PM 9/5/2004, ABC CORPORATE_AFFAIRS5 wrote: Dear Dr Martini Thank you for your email of 8 August 2004. The ABC has investigated your concerns and reviewed the content of the journals and websites referenced in your email. However, the ABC cannot agree that Dr Karl has misinformed its audience. Having comprehensively reviewed your literature and Dr Karl's original references, the ABC believes that no medical evidence has been presented to support the claims about the toxicity of the substance. Nevertheless, please be assured that your views have been noted. Your sincerely Kieran Doyle ABC Audience and Consumer Affairs Good answer Kieran. ABC has the right to its opinion. And, in this case, it choose the right one. But thank you Ms Martini for sharing yours, no matter how stupid. Below is the result of your feedback form. It was submitted by Dr. Betty Martini ) on Sunday, August 08, 2004 at 05:21:33 --------------------------------------------------------------------------- From: http://www.abc.net.au/contact/ locationS: Outside Australia program: Dr. Karl on your ABC web site comments: The Dr. Karl on the web site is giving out misinformation. I'm the one who lectured for the World Environmental Conference and everything I lectured on has been documented in the medical text on the global plague of Aspartame Disease: Aspartame Disease: An Ignored Epidemic, www.sunsentpress.com by world expert H. J. Roberts, M.D. Lawsuits have already been filed against some of the largest companies in the world for poisoning the public on the subject. Here is one of my posts I would appreciate you adding to your web site to counteract Dr. Karl's misinformation. Please reply to me. Dr. Betty Martini, ASPARTAME: NO HOAX, CRIME OF THE CENTURY (FRONT GROUPS IN VIOLATION OF TITLE 18, SECTION 1001 WHEN THEY LIE ABOUT THE ASPARTAME ISSUE AND STUMBLE OTHERS) By Dr. Betty Martini Mission Possible International 9270 River Club Parkway Duluth, Georgia 30097 Telephone: 770-242-2599 E-Mail: Web Site: http://www.dorway.com 18 July 2004 This is in repose to the posting that aspartame being harmful is nothing more than a hoax at: http://www.snopes.com/toxins/aspartame.asp Dear Whoever you are who doesn't want to sign their name: First of all, I'm Dr. Betty Martini, Founder of Mission Possible International, a worldwide volunteer force in 50 states and over 22 countries of the world getting information from world experts on aspartame to the general public to alert them of the dangers. Who are you who goes to "front groups" to get information. Snoops and Urban Legends are in violation of Title 18, Section 1001 of the Criminal Code for stumbling the people. Obviously, we've sent them my invitation to speak for the World Environmental Conference, and confirmation by Dr. Clarice Gaylord that I did speak, who is with the EPA and gave the keynote address. That information is on http://www.dorway.com/nomarkle.html Secondly, its all a mute point since H. J. Roberts, M.D. has declared Aspartame Disease to be a global plague and published the medical text, Aspartame Disease: An Ignored Epidemic, http://www.sunsentpress.com or 1-800-827-7991. How about if I declare George Bush a total bung hole? While, in this case, my declaration would be accurate, a declaration does not mean much. H.J. Roberts can declare himself the best doctor in the world, but so what? Evidence speaks, and the evidence shows aspartame to be safe. This 1038 page medical text documents everything I lectured on from MS and lupus to diabetes and brain tumors. Not only that but its even documented in a new movie, Sweet Misery: A Poisoned World. You can get a copy from Sound And Fury Productions ) It has the world experts on aspartame in it, Doctors Roberts, Blaylock, Walton, Olney, Bowen and even a former FDA Investigator, Arthur Evangelista explaining how deadly aspartame is. Dr. Bowen? Isn't the biggest asshole in alternatvie medicine? But he is in stupid company with the other doctors. Furthermore, suit have now been filed against some of the world's largest companies for poisoning the public with aspartame including Coke, Pepsi, Slimfast, Atria - General Foods, Walmart, Bayer, etc., etc. Read it all on http://www.wnho.net Too bad. Filing a lawsuit doesn't mean crap. A bunch of bogus lawsuits have been filed. Also, Dr. Blaylock, a neurosurgeon, just released a paper on the MS and Aspartame connection with new research. I'll send it to you. And here is a note from Ed Johnson to Snoops and Urban Legends who worked for the Justice Department. I don't know whether you're just someone who is ignorant and didn't realize there are people who take money to lie. These guys have been told for years and sent all confirming information. In fact, a new book just recently came out by Michael Barbee that exposes this. It's called Politically Incorrect Nutrition. Regarding this issue, and on page 49 it says: "Betty Martini is an aspartame activist. She created quite a stir in l995 when a letter she wrote, based on her talks at the World Environmental Conference that year, found it way to the Internet as the "Nancy Markle" letter. It was widely circulated and shocked the world. She clearly laid out the dangers of aspartame consumption and showed how government and corporate interests put profits ahead of public health." She clearly laid out her gullibility and stupidity ."She was attacked, however, by some who felt the information belonged to the category of "urban legend" or "urban rumor." One prominent critic said that she left too many unanswered questions. When Ms. Martini answered those questions, her critic refused to put them on his web site." perhaps, because, she is a clueless twit? "Another so-called "exposer of junk science" who tried to discredit her position over the Internet was, in fact, a former lobbyist for the tobacco industry and directed an organization created by Philip Morris to attack the EPA's position on second-hand smoke. He and other shills working for industry front-groups have formed much of Ms. Martini's opposition." So you see, they didn't get away with it. They have all been exposed now and I'm surprised you didn't know or are you somebody who just wanted to see what we send out when somebody has read their lies? You notice I'm sending them a copy of those notes. Did you know there is a name for those "who do it for money"! Since my lecturing for the World Environmental Conference has been confirmed why would one call it a hoax unless they were paid to do so? But I'm glad to get those notes so I can refer them again to the Justice Department where they have been reported many times for being in violation of Title 18, Section 1001. Personally, I have no respect for those who lie. And below is what we send out when people are lied to. I'll send you separately, the new paper on the MS and Aspartame connection with current research substantiating the issue. The Idaho Observer has put out 24 page booklets for distributing on Aspartame Disease, although they have changed the name to Rumsfeld Disease, since he got it approved with a lot of politics when the FDA said to revoke the petition for approval. Get the movie and find out just how far he went. The reason Snoops and Urban Legends have failed is that my number is all over the Internet and web sites so anything can call and get the facts. And we have all the documentation. Be sure to also check the Aspartame Toxicity Center, http://www.holisticmed.com/aspartame Dr. Betty Martini Founder, Mission Possible International 9270 River Club Parkway Duluth, Georgia 30097 770-242-2599 http://www.dorway.com http://www.whno.net I still think it should be called "Mission Stupid." It fits the mission and the founder well. Jeff |
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Extract: Inspite of decades of scientific research attesting to the safety of aspartame, negative allegations about the safety of aspartame have appeared in the media and on the internet for a number of years. Some of the most common allegations and the scientific facts refuting them are as follows.... http://www.hc-sc.gc.ca/food-aliment/...partame02.html Article begins here.. http://www.hc-sc.gc.ca/food-aliment/...partame01.html |
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Not-A-Doctor Martini claimed for years that Aspartame would cause a pandemic
of blindness. I am still wating. "CWatters" wrote in message ... Extract: Inspite of decades of scientific research attesting to the safety of aspartame, negative allegations about the safety of aspartame have appeared in the media and on the internet for a number of years. Some of the most common allegations and the scientific facts refuting them are as follows.... http://www.hc-sc.gc.ca/food-aliment/...partame02.html Article begins here.. http://www.hc-sc.gc.ca/food-aliment/...partame01.html |
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French Study Confirms Safety Of Aspartame
---------------------------------------------------------------------------- ---- Food Insight NewsBite May/June 2002 Recently, after an extensive evaluation of the scientific literature on the sweetener aspartame, a committee of independent scientific experts selected by the French Food Safety Agency (AFSSA) reaffirmed the safety of aspartame. http://www.ific.org/foodinsight/2002...amenbfi302.cfm |
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"CWatters" wrote in message ... French Study Confirms Safety Of Aspartame -------------------------------------------------------------------------- -- Yeah, Independent my ass. Watch the DVD Sweet Misery http://www.whale.to/w/excitotoxins.html You are acting like a real pharma agent |
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"john" wrote in message ... "CWatters" wrote in message ... French Study Confirms Safety Of Aspartame -------------------------------------------------------------------------- -- Yeah, Independent my ass. Watch the DVD Sweet Misery http://www.whale.to/w/excitotoxins.html You are acting like a real pharma agent Or someone who is able to seperate fact from fiction. The whaleto site counts as stupidity. The author is to ashamed to put her name on it. And she clearly doesn't have a clue about the science or medicine. Jeff |
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http://groups.yahoo.com/group/aspartameNM/message/927 Donald Rumsfeld, 1977 head of Searle Corp., got aspartame FDA approval: Turner: Murray 2002.12.23 rmforall A very detailed, highly credible account of the dubious approval process for aspartame in July, 1981 is part of the just released two-hour documentary "Sweet Misery, A Poisoned World: An Industry Case Study of a Food Supply In Crisis" by Cori Brackett: http://www.soundandfuryproductions.com/ 520-624-9710 2301 East Broadway, Suite 111 Tucson, AZ 85719 ************************************************** ************ http://groups.yahoo.com/group/aspartameNM/message/1088 Murray, full plain text & critique: chronic aspartame in rats affects memory, brain cholinergic receptors, and brain chemistry, Christian B, McConnaughey M et al, 2004 May: 2004.06.05 rmforall Pharmacol Biochem Behav. 2004 May; 78(1): 121-7. Chronic aspartame affects T-maze performance, brain cholinergic receptors and Na(+),K(+)-ATPase in rats. Christian B, McConnaughey K, Bethea E, Brantley S, Coffey A, Hammond L, Harrell S, Metcalf K, Muehlenbein D, Spruill W, Brinson L, McConnaughey M. Department of Pharmacology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA; North Carolina School of Science and Mathematics, Durham, NC 27811. http://www.ecu.edu/pharmacology/facu...onnaughey.html Mona M. McConnaughey, Ph.D. Research Assistant Professor Department: PHARMACOLOGY & TOXICOLOGY Office: Brody Medical Science 6E-120A 252-744-2756 This study demonstrated that chronic aspartame consumption in rats can lead to altered T-maze performance and increased muscarinic cholinergic receptor densities in certain brain regions. Control and treated rats were trained in a T-maze to a particular side and then periodically tested to see how well they retained the learned response. Rats that had received aspartame (250 mg/kg/day) in the drinking water for 3 or 4 months showed a significant increase in time to reach the reward in the T-maze, suggesting a possible effect on memory due to the artificial sweetener. Using [(3)H]quinuclidinyl benzilate (QNB) (1 nM) to label muscarinic cholinergic receptors and atropine (10(-6) M) to determine nonspecific binding in whole-brain preparations, aspartame-treated rats showed a 31% increase in receptor numbers when compared to controls. In aspartame-treated rats, there was a significant increase in muscarinic receptor densities in the frontal cortex, midcortex, posterior cortex, hippocampus, hypothalamus and cerebellum of 80%, 60%, 61%, 65%, 66% and 60%, respectively. The midbrain was the only area where preparations from aspartame-treated rats showed a significant increase in Na(+),K(+)-ATPase activity. It can be concluded from these data that long-term consumption of aspartame can affect T-maze performance in rats and alter receptor densities or enzymes in brain. PMID: 15159141 http://groups.yahoo.com/group/aspartameNM/message/1067 eyelid contact dermatitis by formaldehyde from aspartame, AM Hill & DV Belsito, Nov 2003: Murray 2004.03.30 rmforall [ 150 KB ] "A 60-year-old Caucasian woman presented with a 6-month history of eyelid dermatitis... By strictly avoiding formaldehyde and all formaldehyde releasers for the next 3 weeks, she improved only slightly. Her problem, however, was subsequently solved when a local pharmacist advised her to avoid aspartame. She had begun using an aspartame-based artificial sweetener 5 months prior to the onset of her dermatitis. [ 12 months of low-level aspartame use until stopping. ] Within 1 week of discontinuing the aspartame, her eyelid dermatitis resolved completely and has not recurred over 18 months without specific treatment.... Our patient was consuming an average of 80 mg (1.13 mg/kg) of aspartame daily, well below the levels previously studied." [ A packet of tabletop sweetener gives 37 mg aspartame, while a 12 oz diet soda gives 200 mg aspartame. An aspartame reactor can have immediate strong symtoms from an under-the-tongue wafer with 4 mg aspartame. ] ************************************************** ************ http://groups.yahoo.com/group/aspartameNM/message/1106 hangover research relevant to toxicity of 11% methanol in aspartame (formaldehyde, formic acid): Calder I (full text): Jones AW: also some methanol from fruit pectin in colon: Murray 2004.09.11 rmforall Rich Murray, MA Room For All 1943 Otowi Road, Santa Fe, New Mexico 87505 USA 505-501-2298 [ NutraSweet, Equal, Canderel, Benevia, E951 ] Since no adaquate data has ever been published on the exact disposition of the toxic metabolites, formaldehyde and formic acid, in specific tissues in humans of the readily released 11% methanol component of aspartame, the many studies on morning-after hangover from the methanol impurity in alcohol drinks are the main available resource to date. Jones AW (1987) found next-morning hangover from red wine with 100 to 150 mg methanol (9.5% w/v ethanol; 100 mg/l methanol = 0.01%, one part in ten thousand). The expert review by Monte WC (1984) states: "An alcoholic consuming 1500 calories a day from alcoholic sources alone may consume between 0 and 600 mg of methanol each day depending on his choice of beverages (Table 1)...." Table 1 lists red wine as having 128 mg/l methanol, about one part in ten thousand. Fully 11% of aspartame is methanol -- 1,120 mg aspartame in 2 L diet soda, almost six 12-oz cans, gives 123 mg methanol (wood alcohol) -- the same amount that produces hangover from red wine. Other strong formaldehyde sources are tobacco and wood smoke, and the particleboard and new furniture, carpet, and drapes especially concentrated in mobile homes. Similar potent levels of methanol, and its inevitable products in the human body, formaldehyde and formic acid, can also ensue from degradation of fruit pectins in the colon: Alcohol Clin Exp Res. 1997 Aug; 21(5): 939-43. Endogenous production of methanol after the consumption of fruit. Lindinger W, Taucher J, Jordan A, Hansel A, Vogel W. Institut fur Ionenphysik, Leopold Franzens Universitat Innsbruck, Austria. After the consumption of fruit, the concentration of methanol in the human body increases by as much as an order of magnitude. This is due to the degradation of natural pectin (which is esterified with methyl alcohol) in the human colon. In vivo tests performed by means of proton-transfer-reaction mass spectrometry show that consumed pectin in either a pure form (10 to 15 g) or a natural form (in 1 kg of apples) induces a significant increase of methanol in the breath (and by inference in the blood) of humans. The amount generated from pectin (0.4 to 1.4 mg) is approximately equivalent to the total daily endogenous production (measured to be 0.3 to 0.6 mg/day) or that obtained from 0.3 liters of 80-proof brandy (calculated to be 0.5 mg). [ typos corrected, g actually is mg for ethanol, methanol ] This dietary pectin may contribute to the development of nonalcoholic cirrhosis of the liver. PMID: 9267548 Alcohol Clin Exp Res. 1995 Oct; 19(5): 1147-50. Methanol in human breath. Taucher J, Lagg A, Hansel A, Vogel W, Lindinger W. Institut fur Ionenphysik, Universitat Innsbruck, Austria. Using proton transfer reaction-mass spectrometry for trace gas analysis of the human breath, the concentrations of methanol and ethanol have been measured for various test persons consuming alcoholic beverages and various amounts of fruits, respectively. The methanol concentrations increased from a natural (physiological) level of approximately 0.4 ppm up to approximately 2 ppm a few hours after eating about 1/2 kg of fruits, and about the same concentration was reached after drinking of 100 ml brandy containing 24% volume of ethanol and 0.19% volume of methanol. [ 24 ml = 64 mg ethanol and 0.19 ml = 0.33 mg methanol ] PMID: 8561283 These three potent dietary sources of methanol, formaldehyde, and formic acid, which impact many people, and cause the same symptoms in vulnerable and sensitized people, are ignored in the following prestigious, official source: http://groups.yahoo.com/group/aspartameNM/message/1108 faults in 1999 July EPA 468-page formaldehyde profile: Elzbieta Skrzydlewska PhD, Assc. Prof., Medical U. of Bialystok, Poland, abstracts -- ethanol, methanol, formaldehyde, formic acid, acetaldehyde, lipid peroxidation, green tea, aging, Lyme disease: Murray 2004.08.08 rmforall http://groups.yahoo.com/group/aspartameNM/message/1109 Toxicological Profile for Formaldehyde 1/4 plain text, start to 111 of 468 pages USA DHHS PHS ATSDR 1999 July: Murray 2004.08.30 rmforall An editorial review by Ian Calder, F.R.C.A., "Hangovers: not the ethanol-- perhaps the methanol", British Medical Journal 1997 Jan 4; 314(7073): 2 [ Tel/Fax: 0171 720 9279 Consultant Anaesthetist at the National Hospital for Neurology and Neurosurgery, London WCIN 3BG, UK ] http://bmj.bmjjournals.com/search.dtl search to get free full text ] , states: "In fact, ethanol itself may play only a minor part in producing the thirst, headache, fatigue, nausea, sweating, tremor, remorse, and anxiety that hangover sufferers report.... [ Also, dizziness is common. ] "Between a quarter and a half of drinkers claim not to experience hangover symptoms despite having been intoxicated. (three citations)" The symptom list is similar to reports by aspartame reactors. If only a fraction of aspartame users happen to be vulnerable to the methanol, that would account well for the disbelief by those who are not aspartame reactors, as well as the scientific difficulty in proving aspartame toxicity in the general population. Research can study whether the hangover prone are also vulnerable to aspartame, methanol, formaldehyde, and formic acid, and determine the specific biochemistry for different groups. Hangover treatments may help aspartame reactors. For instance, adaquate folic acid (folate) helps humans eliminate toxic products from methanol. Reprod Toxicol. 1996 Nov-Dec; 10(6): 455-63. Influence of dietary folic acid on the developmental toxicity of methanol and the frequency of chromosomal breakage in the CD-1 mouse. Fu SS, Sakanashi TM, Rogers JM, Hong KH, Keen CL. Department of Nutrition, University of California, Davis 95616, USA. "These results show that marginal folate deficiency in pregnant dams significantly increases the teratogenicity of MeOH." PMID: 8946559 There are no reports of hangover from heavy use of orange juice, 34 mg/l methanol, since the methanol in many fruits and vegetables is locked up in complex pectin molecules, not released by human digestion. (Monte WC 1984) I've never found any reports by aspartame reactors, who are often sensitive even to a single breath mint or stick of chewing gum (0.4 to 0.8 mg methanol), of having the same symptoms from fruits or vegetables. Pharmacol Toxicol. 1987 Mar; 60(3): 217-20. Elimination half-life of methanol during hangover. Jones AW. Department of Forensic Toxicology, University Hospital, SE-581 85 Linkoping, Sweden. This paper reports the elimination half-life of methanol in human volunteers. Experiments were made during the morning after the subjects had consumed 1000-1500 ml red wine (9.5% w/v ethanol, 100 mg/l methanol) the previous evening. [ 100 to 150 mg methanol ] The washout of methanol from the body coincided with the onset of hangover. The concentrations of ethanol and methanol in blood were determined indirectly by analysis of end-expired alveolar air. In the morning when blood-ethanol dropped below the Km of liver alcohol dehydrogenase (ADH) of about 100 mg/l (2.2 mM), the disappearance half-life of ethanol was 21, 22, 18 and 15 min. in 4 test subjects respectively. The corresponding elimination half-lives of methanol were 213, 110, 133 and 142 min. in these same individuals. The experimental design outlined in this paper can be used to obtain useful data on elimination kinetics of methanol in human volunteers without undue ethical limitations. Circumstantial evidence is presented to link methanol or its toxic metabolic products, formaldehyde and formic acid, with the pathogenesis of hangover. PMID: 3588516 http://groups.yahoo.com/group/aspartameNM/message/1047 Avoiding Hangover Hell 2003.12.31 Mark Sherman, AP writer: Robert Swift, MD [ formaldehyde from methanol in aspartame ]: Murray 2004.01.16 rmforall http://groups.yahoo.com/group/aspartameNM/message/1048 hangovers from formaldehyde from methanol (aspartame?): Schwarcz: Linsley: Murray 2004.01.18 http://groups.yahoo.com/group/aspartameNM/message/1099 Diagnose-Me.com: formaldehyde from 11 % methanol part of aspartame: recent abstracts for methanol and hangovers: Murray 2004.07.10 rmforall http://bmj.bmjjournals.com/search.dtl search to get free full text British Medial Journal 1997 (4 January); 314(7073): 2. Ian Calder, F.R.C.A. [ Tel/Fax: 0171 720 9279 Consultant Anaesthetist at the National Hospital for Neurology and Neurosurgery, London WCIN 3BG, UK ] Editorials Hangovers: Not the ethanol - perhaps the methanol "Wine is only sweet to happy men," wrote an unhappy John Keats to his sweetheart.(1) His observation seems to have been vindicated. Harburg et al found that psychosocial factors such as guilt about drinking, a neurotic personality, becoming angry or depressed while drinking, and having suffered "negative life events" in the past 12 months are better predictors of symptoms of hangover than the amount of ethanol drunk.(2) In fact, ethanol itself may play only a minor part in producing the thirst, headache, fatigue, nausea, sweating, tremor, remorse, and anxiety that hangover sufferers report. Hangover symptoms are worst at a time when almost all ethanol and its metabolite acetaldehyde have been cleared from the blood, and peak blood ethanol or acetaldehyde levels are not related to the severity of hangover.(3 ) Between a quarter and a half of drinkers claim not to experience hangover symptoms despite having been intoxicated.(2, 3, 4) Congeners - complex organic molecules such as polyphenols, higher alcohols including methanol, and histamine, which occur in varying amounts in ethanolic drinks - are probably more to blame than ethanol. Chapman found that hangover symptoms were almost twice as common in volunteers who drank 1.5 ml/kg [ body weight ] of bourbon whiskey - which has methanol concentrations of 26 mg/l - as in those drinking the same dose of vodka ( 3.9 mg of methanol per litre ). (5) [ For a 60 kg person, this would be 90 mg bourbon, 0.09 l, giving 2.34 mg methanol, which led to twice as many symptoms as the 0.35 mg methanol from vodka. The bourbon gave as about as much methanol as an ounce of diet soda. ] Pawan compared the hangover produced by different types of drink (but only one brand of each) in his study of 20 volunteers. The severity of hangover symptoms declined in the order of brandy, red wine, rum, whisky, white wine, gin, vodka, and pure ethanol.(6) Vodka and pure ethanol caused only mild headaches in two volunteers. Jones has suggested that it is the metabolism of methanol to formaldehyde and formic acid that causes symptoms of hangover, with quicker methanol metabolisers suffering more.(7) The justification for this suggestion is threefold: the types of drink associated with more severe hangovers contain higher levels of methanol; the time course of methanol metabolism corresponds to the onset of symptoms; and a small dose of ethanol, which blocks the formation of formaldehyde and formic acid, provides an effective treatment for hangovers ("the hair of the dog"). The economic and social consequences of hangovers are probably considerable but difficult to quantify. Performance accuracy is impaired synergistically by sleep deprivation and hangover.(8) Drivers perform less well in simulators when tested the morning after drinking ethanol.(9) Making driving with a hangover a criminal offence might be logical, but is probably impractical in the absence of a simple diagnostic test like breath alcohol. Many pathophysiological disturbances occur during hangover, including dehydration; metabolic acidosis; hypoglycaemia; disturbed prostaglandin synthesis; abnormal secretion of vasopressin, cortisol, aldosterone, renin, and testosterone; increased cardiac output; tachycardia; and vasodilatation. Hypoglycaemia and acidosis can be treated with fructose or glucose,(9) and the cardiovascular abnormalities with ß blockade,(10) but symptoms are not alleviated. However, rehydration and anti-inflammatory analgesics are helpful, particularly if treatment is started before bedtime.(11) A completely effective treatment is probably unattainable (since so many factors - such as lack of sleep, active or passive smoking, dietary indiscretions, unaccustomed physical activity, intermittent upper airway obstruction, and emotional disturbances - must play a part) and is arguably undesirable since the fear of hangover prompts most people to moderate their ethanol intake.(4 ) Even moderate amounts of ethanol can be damaging,(12) so a penalty for consumption is in our interests. Perhaps those who aspire to be one of Dr Johnson's "heroes" by drinking brandy (13) are sensible as well as brave. Ian Calder, Consultant anaesthetist, Department of Neuroanaesthesia, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG UK 1. Keats J. Letter to Fanny Brawne. In: Tripp RT, ed. The international thesaurus of quotations. England: Penguin, 1976: 266. 2. Harburg E, Gunn R, Gleiberman L, DiFranceisco W, Schork A. Psychosocial factors, alcohol use and hangover signs among social drinkers: a reappraisal. J Clin Epidemiol 1993; 46: 413-22. [Medline] 3. Ylikahri RH, Huttunen M, Eriksson CJ, Nikkila EA. Metabolic studies on the pathogenesis of hangover. Eur J Clin Invest 1974; 4: 93-100. 4. Smith CM, Barnes GM. Signs and symptoms of hangover; prevalence and relationship to alcohol use in a generally adult population. Drug Alcohol Depend 1983; 11: 249-69. [Medline] 5. Chapman LF. Experimental induction of hangover. Q J Stud Alcohol 1970; 5: 67-85. [Medline] 6. Pawan GLS. Alcoholic drinks and hangover effects. Proc Nutr Soc 1973; 32: 15A. 7. Jones AW. Elimination half-life of methanol during hangover. Pharmacol Toxicol 1987; 60; 217-20. 8. Peeke SC, Callaway E, Jones RT, Stone GC, Doyle J. Combined effect of alcohol and sleep deprivation in normal young adults. Psychopharmacol 1980; 67: 279-87. [Medline] 9. Seppala T, Leino T, Linnoila M, Huttunen MO, Ylikahri RH. Effects of hangover on psychomotor skills related to driving: modification by fructose and glucose. Acta Pharmacol Toxicol 1976; 38: 209-18. 10. Bogin RM, Nostrant TT, Young MJ. Propranolol for the treatment of the alcoholic hangover. Am J Drug Alcohol Abuse 1986; 12: 279-84. 11. Khan MA, Jensen K, Krogh HJ. Alcohol induced hangover. A double blind comparison of pyritinol and placebo in preventing hangover symptoms. Q J Stud Alcohol 1973; 34: 1195-201. [Medline] 12. Karhunen PJ, Erkinjuntti T, Laippala P. Moderate alcohol consumption and loss of cerebellar Purkinje cells. BMJ 1994; 308: 1663-7. 13. Boswell J. Life of Johnson. April 7th 1779. Oxford University Press: Oxford, 1970. This article has been cited by other articles: M. H. Pittler, A. R. White, C. Stevinson, and E. Ernst. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial Can. Med. Assoc. J., December 9, 2003; 169(12): 1269 - 1273. [Abstract] [Full Text] [PDF] W. T Thompson, M. E Cupples, C. H Sibbett, D. I Skan, and T. Bradley. Challenge of culture, conscience, and contract to general practitioners' care of their own health: qualitative study BMJ, September 29, 2001; 323(7315): 728 - 731. [Abstract] [Full Text] [PDF] Š 2004 BMJ Publishing Group Ltd ************************************************** ************ http://groups.yahoo.com/group/aspartameNM/message/1100 research on aspartame (methanol, formaldehyde, formic acid) toxicity: Murray 2004.09.11 rmforall Rich Murray, MA Room For All 1943 Otowi Road, Santa Fe, New Mexico 87505 USA 505-501-2298 [ NutraSweet, Equal, Canderel, Benevia, E951 ] http://groups.yahoo.com/group/aspartameNM/message/927 Donald Rumsfeld, 1977 head of Searle Corp., got aspartame FDA approval: Turner: Murray 2002.12.23 rmforall A very detailed, highly credible account of the dubious approval process for aspartame in July, 1981 is part of the just released two-hour documentary "Sweet Misery, A Poisoned World: An Industry Case Study of a Food Supply In Crisis" by Cori Brackett: http://www.soundandfuryproductions.com/ 520-624-9710 2301 East Broadway, Suite 111 Tucson, AZ 85719 http://groups.yahoo.com/group/aspartameNM/messages 128 members, 1,112 posts in a public searchable archive http://groups.yahoo.com/group/aspartame/messages 828 members, 17,321 posts in a public, searchable archive Poor memory is one of the main early complaints of aspartame reactors, who are often people who use over 6 cans ( 2 L) diet soda daily for years. The 6 experimental rats in this recent economical, focused study by McConnaughey M et al (2004 May), drank a comparable level for 4 months, about 13% of a 30-month lifespan. It is an excellent introduction to the main issues. Only after 3 months did the 6 aspartame rats show almost a doubling of time to run a single-choice maze. At 4 months, there was almost another doubling of delay: "...two of the treated rats even went to the wrong side of the T-maze, totally forgetting where the reward was." These are very powerful, worrisome results. There were highly significant, neurologically relevant changes in certain brain receptor densities, and changes in brain chemistry. With 70 citations, the relevant scientific literature is well summarized. Many other studies, often industry funded, often used single doses or too short durations of exposure, along with lower doses, thus rarely proving memory deficits. The funding source for this extremely valuable study is not given. It used a team of talented high school students. The fact that certain brain receptor densitities increased, and that memory deficit increase took 3 months to be significant, may reflect the paradox of hormesis, the complex ability of organisms to make themselves stronger in response to low levels of toxins: http://groups.yahoo.com/group/aspartameNM/message/1055 hormesis: possible benefits of low-level aspartame (methanol, formaldehyde) use: Calabrese: Soffritti: Murray 2004.03.11 rmforall The most toxic part of the fragile aspartame molecule is its 11% methanol component. It is an open secret, admitted in a number of published studies for three decades, that methanol is converted within hours by the liver into formaldehyde and formic acid, both potent, cumulative toxins that affect all cell types. Few know that the classic "morning after" hangover from dark wines and liquors is largely due to formaldehyde and formic acid from methanol contamination, not the ethanol itself. The actual disposition of these toxins in the tissues of human aspartame reactors has never been determined, or, if determined, never publicly published. The study should be replicated, using methanol, formaldehyde, and formic acid to verify if the same results obtain. If blood and tissue samples have been stored, then the fast, cheap, automated, highly sensitive Comet assay, often used to prove DNA damage from formaldehyde, can be used to replicate the results by Yu F. Sakaki (2002), whose intripid and much published team in Japan has found DNA damage, testing 8 tissues from single non-lethal doses of aspartame (near-significant high levels of DNA damage in 5 tissues) and 38 other additives in groups of just 4 mice: http://groups.yahoo.com/group/aspartameNM/message/935 Comet assay finds DNA damage from sucralose, cyclamate, saccharin in mice: Sasaki YF & Tsuda S Aug 2002: Murray 2003.01.01 rmforall [ Also borderline evidence, in this pilot study of 39 food additives, using test groups of 4 mice, for DNA damage from for stomach, colon, liver, bladder, and lung 3 hr after oral dose of 2000 mg/kg aspartame-- a very high dose. Methanol is the only component of aspartame that can lead to DNA damage. ] http://groups.yahoo.com/group/aspartameNM/message/1108 faults in 1999 July EPA 468-page formaldehyde profile: Elzbieta Skrzydlewska PhD, Assc. Prof., Medical U. of Bialystok, Poland, abstracts -- ethanol, methanol, formaldehyde, formic acid, acetaldehyde, lipid peroxidation, green tea, aging, Lyme disease: Murray 2004.08.08 rmforall http://groups.yahoo.com/group/aspartameNM/message/1088 Murray, full plain text & critique: chronic aspartame in rats affects memory, brain cholinergic receptors, and brain chemistry, Christian B, McConnaughey M et al, 2004 May: 2004.06.05 rmforall Pharmacol Biochem Behav. 2004 May; 78(1): 121-7. Chronic aspartame affects T-maze performance, brain cholinergic receptors and Na(+),K(+)-ATPase in rats. Christian B, McConnaughey K, Bethea E, Brantley S, Coffey A, Hammond L, Harrell S, Metcalf K, Muehlenbein D, Spruill W, Brinson L, McConnaughey M. Department of Pharmacology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA; North Carolina School of Science and Mathematics, Durham, NC 27811. http://www.ecu.edu/pharmacology/facu...onnaughey.html Mona M. McConnaughey, Ph.D. Research Assistant Professor Department: PHARMACOLOGY & TOXICOLOGY Office: Brody Medical Science 6E-120A 252-744-2756 This study demonstrated that chronic aspartame consumption in rats can lead to altered T-maze performance and increased muscarinic cholinergic receptor densities in certain brain regions. Control and treated rats were trained in a T-maze to a particular side and then periodically tested to see how well they retained the learned response. Rats that had received aspartame (250 mg/kg/day) in the drinking water for 3 or 4 months showed a significant increase in time to reach the reward in the T-maze, suggesting a possible effect on memory due to the artificial sweetener. Using [(3)H]quinuclidinyl benzilate (QNB) (1 nM) to label muscarinic cholinergic receptors and atropine (10(-6) M) to determine nonspecific binding in whole-brain preparations, aspartame-treated rats showed a 31% increase in receptor numbers when compared to controls. In aspartame-treated rats, there was a significant increase in muscarinic receptor densities in the frontal cortex, midcortex, posterior cortex, hippocampus, hypothalamus and cerebellum of 80%, 60%, 61%, 65%, 66% and 60%, respectively. The midbrain was the only area where preparations from aspartame-treated rats showed a significant increase in Na(+),K(+)-ATPase activity. It can be concluded from these data that long-term consumption of aspartame can affect T-maze performance in rats and alter receptor densities or enzymes in brain. PMID: 15159141 http://groups.yahoo.com/group/aspartameNM/message/1067 eyelid contact dermatitis by formaldehyde from aspartame, AM Hill & DV Belsito, Nov 2003: Murray 2004.03.30 rmforall [ 150 KB ] "A 60-year-old Caucasian woman presented with a 6-month history of eyelid dermatitis... By strictly avoiding formaldehyde and all formaldehyde releasers for the next 3 weeks, she improved only slightly. Her problem, however, was subsequently solved when a local pharmacist advised her to avoid aspartame. She had begun using an aspartame-based artificial sweetener 5 months prior to the onset of her dermatitis. [ 12 months of low-level aspartame use until stopping. ] Within 1 week of discontinuing the aspartame, her eyelid dermatitis resolved completely and has not recurred over 18 months without specific treatment.... Our patient was consuming an average of 80 mg (1.13 mg/kg) of aspartame daily, well below the levels previously studied." [ A packet of tabletop sweetener gives 37 mg aspartame, while a 12 oz diet soda gives 200 mg aspartame. An aspartame reactor can have immediate strong symtoms from an under-the-tongue wafer with 4 mg aspartame. ] http://groups.yahoo.com/group/aspartameNM/message/1039 three-page review: aspartame (methanol, formaldehyde) toxicity: Murray 2003.11.22 rmforall http://groups.yahoo.com/group/aspartameNM/message/1026 brief aspartame review: formaldehyde toxicity: Murray 2003.09.11 rmforall http://groups.yahoo.com/group/aspartameNM/message/1025 aspartame & formaldehyde toxicity: Murray 2003.09.09 rmforall http://groups.yahoo.com/group/aspartameNM/message/1094 the 11% methanol component of aspartame becomes formaldehyde, now ruled a carcinogen by WHO International Agency for Research on Cancer: Murray 2004.06.16 rmforall http://groups.yahoo.com/group/aspartameNM/message/1084 26 stevia safety abstracts since 1993: aspartame vs stevia debate on alt.support.diabetes, George Schmidt, OD: Murray 2004.05.25 rmforall A Searle Laboratories team in 1976 reported that in 4 monkeys fed aspartame, by 12 hours: "...the major fraction (70%) of the [aspartate] label appeared in the expired air (Fig.6)...Urinary and fecal 14C [ aspartate derived ] amounted to 4--6% of the administered [ aspartate ] label." This gives a total of a maximum 76% excreted aspartate from the aspartame, indicating that 24% of this excitotoxin was retained in the body. It is reasonable to conclude that daily use of aspartame must lead to substantial accumulation of this excitotoxin, aspartate, in body tissues. Their 1979 review said: "Aspartame... is hydrolyzed in the gut to yield aspartic acid, phenylalanine, and methanol.... Aspartate may also be incorporated into body constitutents such as other amino acids, proteins, pyrimidines, asparagine, and N-acetylaspartic acid." J Environ Pathol Toxicol. 1979 Mar-Apr; 2(4): 979-85. A review of the metabolism of the aspartyl moiety of aspartame in experimental animals and man. Ranney RE, Oppermann JA. Department of Drug Metabolism and Radiochemistry, Searle Laboratories, Skokie, Illinois. Division of G.D. Searle and Co. Box 5110, Chicago, IL 60680 Aspartame (3-amino-N-(alpha-carboxyphenethyl) succinamic acid, methyl ester; the methyl ester of aspartylphenylalanine, SC-18862) is hydrolyzed in the gut to yield aspartic acid, phenylalanine, and methanol. This review of the literature describes the metabolic paths followed by aspartate in its conversion to CO2 or its incorporation into body constituents. About 70 percent of 14C from [asp-14C]-aspartame is converted in the monkey to 14CO2. Some of the aspartate is converted at the intestinal mucosal level to alanine by decarboxylation. This amino acid may be oxidized to CO2 by entering the tricarboxylic acid cycle via pyruvate and acetyl CoA. In addition, transamination of aspartate to oxaloacetate permits this product also to enter the tricarboxylic acid cycle. Aspartate may also be incorporated into body constitutents such as other amino acids, proteins, pyrimidines, asparagine, and N-acetylaspartic acid. It is concluded that the aspartate moiety of aspartame is metabolized in a manner similar to that of dietary aspartic acid. Publication Types: Review PMID: 376770 It is certain that high levels of aspartame use, above 2 liters daily for months and years, must lead to chronic formaldehyde-formic acid toxicity. Fully 11% of aspartame is methanol-- 1,120 mg aspartame in 2 L diet soda, almost six 12-oz cans, gives 123 mg methanol (wood alcohol). The methanol is immediately released into the body after drinking-- unlike the large levels of methanol locked up in complex molecules inside many fruits and vegetables. Within hours, the liver turns much of the methanol into formaldehyde, and then much of that into formic acid, both of which in time are partially eliminated as carbon dioxide and water. However, about 30% of the methanol remains in the body as cumulative durable toxic metabolites of formaldehyde and formic acid-- 37 mg daily, a gram every month, accumulating in and affecting every tissue. If only 10% of the methanol is retained daily as formaldehyde, that would give 12 mg daily formaldehyde accumulation-- about 60 times more than the 0.2 mg from 10% retention of the 2 mg EPA daily limit for formaldehyde in drinking water. Bear in mind that the EPA limit for formaldehyde in drinking water is 1 ppm, or 2 mg daily for a typical daily consumption of 2 L of water. http://groups.yahoo.com/group/aspartameNM/message/835 ATSDR: EPA limit 1 ppm formaldehyde in drinking water July 1999: Murray 2002.05.30 rmforall This long-term low-level chronic toxic exposure leads to typical patterns of increasingly severe complex symptoms, starting with headache, fatigue, joint pain, irritability, memory loss, rashes, and leading to vision and eye problems, and even seizures. In many cases there is addiction. Probably there are immune system disorders, with a hypersensitivity to these toxins and other chemicals. J. Nutrition 1973 Oct; 103(10): 1454-1459. Metabolism of aspartame in monkeys. Oppermann JA, Muldoon E, Ranney RE. Dept. of Biochemistry, Searle Laboratories, Division of G.D. Searle and Co. Box 5110, Chicago, IL 60680 They found that about 70% of the radioactive methanol in aspartame put into the stomachs of 3 to 7 kg monkeys was eliminated within 8 hours, with little additional elimination, as carbon dioxide in exhaled air and as water in the urine. They did not mention that this meant that about 30% of the methanol must transform into formaldehyde and then into formic acid, both of which must remain as toxic products in all parts of the body. They did not report any studies on the distribution of radioactivity in body tissues, except that blood plasma proteins after 4 days held 4% of the initial methanol. This study did not monitor long-term use of aspartame. The low oral dose of aspartame and for methanol was 0.068 mmol/kg, about 1 part per million [ppm] of the acute toxicity level of 2,000 mg/kg, 67,000 mmol/kg, used by McMartin (1979). Two L daily use of diet soda provides 123 mg methanol, 2 mg/kg for a 60 kg person, a dose of 67 mmole/kg, a thousand times more than the dose in this study. By eight hours excretion of the dose in air and urine had leveled off at 67.1 +-2.1% as CO2 in the exhaled air and 1.57+-0.32% in the urine, so 68.7% was excreted, and 31.3% was retained. This data is the average of 4 monkeys. "...the 14C in the feces was negligible." "That fraction not so excreted (about 31%) was converted to body constituents through the one-carbon metabolic pool." "All radioactivity measurements were counted to +-1% accuracy..." This indicates that the results could not be claimed to have a precision of a tenth of a percent. OK, so this is a nit-pick-- but I believe espousing spurious accuracy is a sign of scientific insecurity. The abstract ends, "It was concluded that aspartame was digested to its three constituents that were then absorbed as natural constituents of the diet. Thus, the concept is very subtly insinuated that methanol, as a constituent of aspartame, is absorbed as a natural constituent of the diet." "Dietary methanol is derived in large part from fresh fruits and vegetables." This is a serious error, since the large amounts of methanol in fresh fruits and vegetables, locked up in complex pectin molecules, are not released by normal human digestion. ( Monte WC, 1984) Nowhere in this report are mentioned the dread words, "formaldehyde" and "formic acid". Of course, methanol and formaldehyde toxicity studies are highly relevant to the issue of aspartame toxicity. [ Aspartame has to be turned into its toxic products, formaldehyde and formic acid, in the body, before it is toxic, so some pro-aspartame reseach studies test aspartame outside the body, and then proclaim that they have proved that it is not toxic. ] http://groups.yahoo.com/group/aspartameNM/message/915 formaldehyde toxicity: Thrasher & Kilburn: Shaham: EPA: Gold: Wilson: CIIN: Murray 2002.12.12 rmforall Thrasher (2001): "The major difference is that the Japanese demonstrated the incorporation of FA and its metabolites into the placenta and fetus. The quantity of radioactivity remaining in maternal and fetal tissues at 48 hours was 26.9% of the administered dose." [ Ref. 14-16 ] Arch Environ Health 2001 Jul-Aug; 56(4): 300-11. Embryo toxicity and teratogenicity of formaldehyde. [100 references] Thrasher JD, Kilburn KH. Sam-1 Trust, Alto, New Mexico, USA. http://www.drthrasher.org/formaldehy..._toxicity.html full text http://www.drthrasher.org/formaldehyde_1990.html full text Jack Dwayne Thrasher, Alan Broughton, Roberta Madison. Immune activation and autoantibodies in humans with long-term inhalation exposure to formaldehyde. Archives of Environmental Health. 1990; 45: 217-223. "Immune activation, autoantibodies, and anti-HCHO-HSA antibodies are associated with long-term formaldehyde inhalation." PMID: 2400243 Confirming evidence and a general theory are given by Pall (2002): http://groups.yahoo.com/group/aspartameNM/message/909 testable theory of MCS type diseases, vicious cycle of nitric oxide & peroxynitrite: MSG: formaldehyde-methanol-aspartame: Martin L. Pall: Murray: 2002.12.09 rmforall Environ Health Perspect. 2003 Sep; 111(12): 1461-4. Elevated nitric oxide/peroxynitrite theory of multiple chemical sensitivity: central role of N-methyl-D-aspartate receptors in the sensitivity mechanism. Pall ML. School of Molecular Biosciences, 301 Abelson Hall, Washington State University, Pullman, WA 99164, USA. The elevated nitric oxide/peroxynitrite and the neural sensitization theories of multiple chemical sensitivity (MCS) are extended here to propose a central mechanism for the exquisite sensitivity to organic solvents apparently induced by previous chemical exposure in MCS. This mechanism is centered on the activation of N-methyl-D-aspartate (NMDA) receptors by organic solvents producing elevated nitric oxide and peroxynitrite, leading in turn to increased stimulating of and hypersensitivity of NMDA receptors. In this way, organic solvent exposure may produce progressive sensitivity to organic solvents. Pesticides such as organophosphates and carbamates may act via muscarinic stimulation to produce a similar biochemical and sensitivity response. Accessory mechanisms of sensitivity may involve both increased blood-brain barrier permeability, induced by peroxynitrite, and cytochrome P450 inhibition by nitric oxide. The NMDA hyperactivity/hypersensitivity and excessive nitric oxide/peroxynitrite view of MCS provides answers to many of the most puzzling aspects of MCS while building on previous studies and views of this condition. PMID: 12948884 Prof. Pall describes processes by which an initial trigger exposure, such as carbon monoxide or formaldehyde, can generate hypersensitivity to many substances. He himself had recovered from a sudden, debilitating attack of multiple chemical sensitivity in June/July 1997. http://groups.yahoo.com/group/aspartameNM/message/1055 hormesis: possible benefits of low-level aspartame (methanol, formaldehyde) use: Calabrese: Soffritti: Murray 2004.03.11 rmforall http://groups.yahoo.com/group/aspartameNM/message/1056 disorders of NMDA glutamate receptors in brain range from high activity (MCS, CF, PTSD, FM, from carbon monoxide or formaldehyde (methanol, aspartame)-- Pall) to low activity (schizophrenia-- Coyle, Goff, Javitts): Murray 2004.03.13 rmforall http://groups.yahoo.com/group/aspartameNM/message/1090 aspartame, MSG, excitotoxins, NMDA glutamate receptors, multiple sclerosis: Blaylock: Martini: Murray 2004.06.09 rmforall http://groups.yahoo.com/group/aspartameNM/message/97 Lancet website aspartame letter 1999.07.29: Excitotoxins 1999 Part 1/3 Blaylock: Murray 2000.01.14 rmforall The Medical Sentinel Journal 1999 Fall; (95 references) http://www.dorway.com/blayenn.html http://groups.yahoo.com/group/aspartameNM/message/946 Functional Therapeutics in Neurodegenerative Disease Part 1/2: Perlmutter 1999.07.15: Murray 2003.01.10 rmforall http://groups.yahoo.com/group/aspartameNM/message/1034 Brain cell damage from amino acid isolates (aspartame releases phenylalanine, aspartate, methanol [formaldehyde, formic acid] Bowen & Evangelista May 6 2002: Murray 2003.11.10 rmforall http://www.aspartame.ca/Brain%20Cell%20Damage.pdf Brain cell damage from amino acid isolates 5.6.2 41 references detailed 22 page review by James D. Bowen, MD and Arthur M. Evangelista, former FDA Investigator http://groups.yahoo.com/group/aspartameNM/message/628 Professional House Doctors: Singer: EPA: CPSC: formaldehyde toxicity: Murray 2001.06.10 rmforall http://groups.yahoo.com/group/aspartameNM/message/1052 DMDC: Dimethyl dicarbonate 200mg/L in drinks adds methanol 98 mg/L ( becomes formaldehyde in body ): EU Scientific Committee on Foods 2001.07.12: Murray 2004.01.22 rmforall http://groups.yahoo.com/group/aspartameNM/message/782 RTM: Smith, Terpening, Schmidt, Gums: full text: aspartame, MSG, fibromyalgia 2002.01.17 rmforall Jerry D Smith, Chris M Terpening, Siegfried OF Schmidt, and John G Gums Relief of Fibromyalgia Symptoms Following Discontinuation of Dietary Excitotoxins. The Annals of Pharmacotherapy 2001; 35(6): 702-706. Malcolm Randall Veterans Affairs Medical Center, Gainesville, FL, USA. BACKGROUND: Fibromyalgia is a common rheumatologic disorder that is often difficult to treat effectively. CASE SUMMARY: Four patients diagnosed with fibromyalgia syndrome for two to 17 years are described. All had undergone multiple treatment modalities with limited success. All had complete, or nearly complete, resolution of their symptoms within months after eliminating monosodium glutamate (MSG) or MSG plus aspartame from their diet. All patients were women with multiple comorbidities prior to elimination of MSG. All have had recurrence of symptoms whenever MSG is ingested. Siegfried O. Schmidt, MD Asst. Clinical Prof. Community Health and Family Medicine, U. Florida, Gainesville, FL Shands Hospital West Oak Clinic Gainesville, FL 32608-3629 352-376-5071 http://www.perque.com/ 800-525-7372 http://www.perque.org/Fibromyalgia.pdf A Novel Treatment for Fibromyalgia Imrpoves Clinical Outcomes in a Community-Based Study. Patricia A. Deuster, Russell M. Jaffe. Journal of Musculoskeletal Pain. 1998; Vol. 6(2): 133-149. Using blood tests, the researchers ran a panel of 350 antigens including environmental chemicals, food additives and preservatives, crustaceans, diary products, fish, fruits, grains, meats, mollusks, and oils. Normal, healthy people react to only two or less of this panel. The greatest offenders we MSG 42.5 % (17 out of 40 patients) Candida albicans 37.5 Caffeine 37 Chocolate/cocoa 37 Food colorings 37 Cola beverages 37 Cow Dairy Products 25 Sulfite/metabisulfite 22.5 Xylene 22.5 Yogurt 22.5 Aspartame 20 BHA 20 Cadmium 20 Lead 20 Tylenol 20 Yeast 20 Sodium benzoate 20 Orange 20 C. Trocho (1998): "In all, the rats retained, 6 hours after administration, about 5% of the label, half of it in the liver." They used a very low level of aspartame ingestion, 10 mg/kg, for rats, which have a much greater tolerance for aspartame than humans. So, the corresponding level for humans would be about 1 or 2 mg/kg. Many headache studies in humans used doses of about 30 mg/kg daily. http://groups.yahoo.com/group/aspartameNM/message/925 aspartame puts formaldehyde adducts into tissues, Part 1/2 full text, Trocho & Alemany 1998.06.26: Murray 2002.12.22 rmforall http://ww.presidiotex.com/barcelona/index.html full text Formaldehyde derived from dietary aspartame binds to tissue components in vivo. Life Sci June 26 1998; 63(5): 337-49. Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain. http://www.bq.ub.es/cindex.html Línies de Recerca: Toxicitat de l'aspartame http://www.bq.ub.es/grupno/grup-no.html Sra. Carme Trocho, Sra. Rosario Pardo, Dra. Immaculada Rafecas, Sr. Jordi Virgili, Dr. Xavier Remesar, Dr. Jose Antonio Fernandez-Lopez, Dr. Mariā Alemany [male] Fac. Biologia Tel.: (93)4021521, FAX: (93)4021559 Sra. Carme Trocho "Trok-ho" Fac. Biologia Tel.: (93)4021544, FAX: (93)4021559 ; Abstract: Adult male rats were given an oral dose of 10 mg/kg aspartame, 14C-labeled in the methanol carbon. At timed intervals of up to 6 hours, the radioactivity in plasma and several organs was investigated. Most of the radioactivity found (98% in plasma, 75% in liver) was bound to protein. Label present in liver, plasma and kidney was in the range of 1-2% of total radioactivity administered per g or mL, changing little with time. Other organs (brown and white adipose tissues, muscle, brain, cornea and retina) contained levels of label in the range of 1/12th to 1/10th of that of liver. In all, the rats retained, 6 hours after administration, about 5% of the label, half of it in the liver. The specific radioactivity of tissue protein, RNA and DNA was quite uniform. The protein label was concentrated in amino acids, different from methionine, and largely coincident with the result of protein exposure to labeled formaldehyde. DNA radioactivity was essentially in a single different adduct base, different from the normal bases present in DNA. The nature of the tissue label accumulated was, thus, a direct consequence of formaldehyde binding to tissue structures. The administration of labeled aspartame to a group of cirrhotic rats resulted in comparable label retention by tissue components, which suggests that liver function (or its defect) has little effect on formaldehyde formation from aspartame and binding to biological components. The chronic treatment of a series of rats with 200 mg/kg of non-labeled aspartame during 10 days results in the accumulation of even more label when given the radioactive bolus, suggesting that the amount of formaldehyde adducts coming from aspartame in tissue proteins and nucleic acids may be cumulative. It is concluded that aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts. PMID: 9714421 [ Extracts ] "The high label presence in plasma and liver is in agreement with the carriage of the label from the intestine to the liver via the portal vein. The high label levels in kidney and, to a minor extent, in brown adipose tissue and brain are probably a consequence of their high blood flows (45). Even in white adipose tissue, the levels of radioactivity found 6 hours after oral administration were 1/25th those of liver. Cornea and retina, both tissues known to metabolize actively methanol (21,28) showed low levels of retained label. In any case, the binding of methanol-derived carbon to tissue proteins was widespread, affecting all systems, fully reaching even sensitive targets such as the brain and retina.... The amount of label recovered in tissue components was quite high in all the groups, but especially in the NA rats. In them, the liver alone retained, for a long time, more than 2 % of the methanol carbon given in a single oral dose of aspartame, and the rest of the body stored an additional 2 % or more. These are indeed extremely high levels for adducts of formaldehyde, a substance responsible of chronic deleterious effects (33), that has also been considered carcinogenic (34,47). The repeated occurrence of claims that aspartame produces headache and other neurological and psychological secondary effects-- more often than not challenged by careful analysis-- (5, 9, 10, 15, 48) may eventually find at least a partial explanation in the permanence of the formaldehyde label, since formaldehyde intoxication can induce similar effects (49). The cumulative effects derived from the incorporation of label in the chronic administration model suggests that regular intake of aspartame may result in the progressive accumulation of formaldehyde adducts. It may be further speculated that the formation of adducts can help to explain the chronic effects aspartame consumption may induce on sensitive tissues such as brain (6, 9, 19, 50). In any case, the possible negative effects that the accumulation of formaldehyde adducts can induce is, obviously, long-term. The alteration of protein integrity and function may needs some time to induce substantial effects. The damage to nucleic acids, mainly to DNA, may eventually induce cell death and/or mutations. The results presented suggest that the conversion of aspartame methanol into formaldehyde adducts in significant amounts in vivo should to be taken into account because of the widespread utilization of this sweetener. Further epidemiological and long-term studies are needed to determine the extent of the hazard that aspartame consumption poses for humans." http://groups.yahoo.com/group/aspartameNM/message/864 Butchko, Tephly, McMartin: Alemany: aspartame formaldehyde adducts in rats: Murray 2002.09.08 rmforall Prof. Alemany vigorously affirms the validity of the Trocho study against criticism: Butchko, HH et al [24 authors], Aspartame: review of safety. Regul. Toxicol. Pharmacol. 2002 April 1; 35 (2 Pt 2): S1-93, review available for $35, [an industry paid organ]. Butchko: "When all the research on aspartame, including evaluations in both the premarketing and postmarketing periods, is examined as a whole, it is clear that aspartame is safe, and there are no unresolved questions regarding its safety under conditions of intended use." [ They repeatedly pass on the ageless industry deceit that the methanol in fruits and vegetables is as as biochemically available as that in aspartame-- see the 1984 rebuttal by W.C. Monte. ] In the same report, Schiffman concludes on page S49, not citing any research after 1997, "Thus, the weight of the scientific evidence indicates that aspartame does not cause headache." Dr. Susan S. Schiffman, Dept. of Psychiatry, Duke University 919-684-3303, 660-5657 http://groups.yahoo.com/group/aspartameNM/message/911 RTP ties to industry criticized by CSPI: Murray: 2002.12.09 rmforall http://groups.yahoo.com/group/aspartameNM/message/846 aspartame in Merck Maxalt-MLT worsens migraine, AstraZeneca Zomig, Eli Lilly Zyprexa, J&J Merck Pepcid AC (Famotidine 10mg) Chewable Tab, Pfizer Cool Mint Listerine Pocketpaks: Murray 2002.07.16 rmforall Migraine MLT-Down: an unusual presentation of migraine in patients with aspartame-triggered headaches. Newman LC, Lipton RB Headache 2001 Oct; 41(9): 899-901. [ Merck 10-mg Maxalt-MLT, for migraine, has 3.75 mg aspartame, while 12 oz diet soda has 200 mg. ] Headache Institute, St. Lukes-Roosevelt Hospital Center, New York, NY Department of Neurology Albert Einstein College of Medicine, Bronx, NY Innovative Medical Research http://groups.yahoo.com/group/aspartameNM/message/855 Blumenthall & Vance: aspartame chewing gum headaches Nov 1997: Murray 2002.07.28 rmforall Harvey J. Blumenthal, MD, Dwight A Vance, RPh Chewing Gum Headaches. Headache 1997 Nov-Dec; 37(10): 665-6. Department of Neurology, University of Oklahoma College of Medicine, Tulsa, USA. Aspartame, a popular dietetic sweetener, may provoke headache in some susceptible individuals. Herein, we describe three cases of young women with migraine who reported their headaches could be provoked by chewing gum sweetened with aspartame. [ 6-8 mg aspartame per stick chewing gum ] Subject: Murray: Butchko: Tephly: critique of Trocho report Apr 2002 8.29.2 Date: Fri, 30 Aug 2002 09:49:56 +0200 From: Mariā Alemany To: Rich Murray References: 1 Dear Rich, Thank you for the opportunity to say something about the "paper" by Tephly that followed our study on the incorporation of aspartame-derived methanol label into DNA and protein of rats. I don't know if responding to that publication is worth the effort. Surprisingly, a serious journal, such as Life Sciences published a rebuttal of our previous paper as a normal "research paper", but including no new information neither experimental work. This is only a sample of the "scientific" power of the advocates of aspartame. Anybody can extract conclusions from this anomaly, but it seems to me that there was nothing new in that pamphlet that may add information to what we already explained in our paper. The responses to the questions raised by Tephly are already in our paper, which means that either that it was not read or, worst, it was misread. The presence of aspartame-derived label in DNA and protein adducts is unquestionable and unquestioned, and agrees with previous studies. Then, what importance has the mechanism of incorporation? There were adducts, and they represent loss of function and mutation. That was our thesis. The reference to previous studies showing very low levels of formaldehyde in blood do not refute our data. First of all, measuring formaldehyde is tricky, and in any case, the circulating levels would be below the current limit of detection for most of the methods used. That is the current explanation for the low levels of methanol in plasma after aspartame loading: they are zero, using most of the methods available for methanol, since the expected levels are currently below the limit of detection... In addition, it is not logical to expect to find measurable levels of formaldehyde in a medium (blood) containing a huge amount of protein. Formaldehyde reacts immediately with proteins because it is highly reactive: that is the reason why we have found it in cell protein and DNA. It is absurd to expect it to forfeit binding with cell proteins and go all the way into the bloodstream! Remember that formaldehyde is used to preserve corpses precisely because it binds protein (including those of putrefactive bacteria) and prevents its degradation. The "alternative" point expressed by Tephly, suggesting that aspartame methanol-label goes all the way into formic acid and the C1 pathway was thoroughly refuted by us, using experimental data. There was no labelled methionine nor thymine in protein and DNA respectively in the rat protein we recovered from rats treated with aspartame. This means--unequivocally-- that the label present in DNA and protein adducts was NOT incorporated into amino acids or nucleic acid bases. The only explanation for our data was that the label was in the form of formaldehyde adducts. If this explanation does not satisfy other scientists, they are free to repeat the experiment and show where we went wrong, or to probe and prove experimentally their hypotheses. Otherwise, our results stand unchecked and, consequently, should be deemed true. I hope that this information will help any attentive reader understand why we have left for good this field of study. Best regards. ------------------------------ Prof. Dr. Mariā Alemany Grup de Recerca Nitrogen-Obesitat Departament de Nutriciķ i Bromatologia Facultat de Biologia, Universitat de Barcelona Av. Diagonal, 645; 08028 Barcelona Espanya/Espaņa/Spain tel. +34 93 403 4606; fax: +34 93 403 7064; E-mail: Life Sci 1999; 65(13): PL157-60. [ letter, usually not peer reviewed ] Comments on the purported generation of formaldehyde and adduct formation from the sweetener aspartame. Tephly TR Thomas R. Tephly 319-335-7979 Department of Pharmacology The University of Iowa, Iowa City 52242, USA. A recent paper by Trocho et al. (1) describes experiments meant to show that formaldehyde adducts are formed when rats are administered the sweetener aspartame. These authors assume that the methanol carbon of aspartame generates formaldehyde which then forms adducts with protein, DNA, and RNA. Doses employed range widely. In this letter, studies which have been published previously and which were not cited by these authors are reviewed in order to put into perspective the disposition of methanol and formaldehyde in monkeys and humans, species relevant to the toxicity of methanol and its toxic metabolite, formic acid. PMID: 10503962, UI: 99431287 [ A number of pro-aspartame studies by Tephly and associates, invariably funded by the aspartame industry (Monsanto, NutraSweet) are criticized in detail at: http://www.HolisticMed.com/aspartame Aspartame Toxicity Information Center Mark D. Gold 12 East Side Drive #2-18 Concord, NH 03301 603-225-2100 http://www.holisticmed.com/aspartame.../methanol.html "Scientific Abuse in Aspartame Research" Gold points out that industry methanol assays were too insensitive to properly measure blood methanol levels. ] http://groups.yahoo.com/group/aspartameNM/message/1016 President Bush & formaldehyde (aspartame) toxicity: Ramazzini Foundation carcinogenicity results Dec 2002: Soffritti: Murray 2003.08.03 rmforall p. 88 "The sweetening agent aspartame hydrolyzes in the gastrointestinal tract to become free methyl alcohol, which is metabolized in the liver to formaldehyde, formic acid, and CO2. (11)" Medinsky MA & Dorman DC. 1994; Assessing risks of low-level methanol exposure. CIIT Act. 14: 1-7. Ann N Y Acad Sci. 2002 Dec; 982: 87-105. Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats. Soffritti M, Belpoggi F, Lambertin L, Lauriola M, Padovani M, Maltoni C. Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Formaldehyde was administered for 104 weeks in drinking water supplied ad libitum at concentrations of 1500, 1000, 500, 100, 50, 10, or 0 mg/L to groups of 50 male and 50 female Sprague-Dawley rats beginning at seven weeks of age. Control animals (100 males and 100 females) received tap water only. Acetaldehyde was administered to 50 male and 50 female Sprague-Dawley rats beginning at six weeks of age at concentrations of 2,500, 1,500, 500, 250, 50, or 0 mg/L. Animals were kept under observation until spontaneous death. Formaldehyde and acetaldehyde were found to produce an increase in total malignant tumors in the treated groups and showed specific carcinogenic effects on various organs and tissues. PMID: 12562630 Ann N Y Acad Sci. 2002 Dec; 982: 46-69. Results of long-term experimental studies on the carcinogenicity of methyl alcohol and ethyl alcohol in rats. Soffritti M, Belpoggi F, Cevolani D, Guarino M, Padovani M, Maltoni C. Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Methyl alcohol was administered in drinking water supplied ad libitum at doses of 20,000, 5,000, 500, or 0 ppm to groups of male and female Sprague-Dawley rats 8 weeks old at the start of the experiment. Animals were kept under observation until spontaneous death. Ethyl alcohol was administered by ingestion in drinking water at a concentration of 10% or 0% supplied ad libitum to groups of male and female Sprague-Dawley rats; breeders and offspring were included in the experiment. Treatment started at 39 weeks of age (breeders), 7 days before mating, or from embryo life (offspring) and lasted until their spontaneous death. Under tested experimental conditions, methyl alcohol and ethyl alcohol were demonstrated to be carcinogenic for various organs and tissues. They must also be considered multipotential carcinogenic agents. In addition to causing other tumors, ethyl alcohol induced malignant tumors of the oral cavity, tongue, and lips. These sites have been shown to be target organs in man by epidemiologic studies. Publication Types: Review Review, Tutorial PMID: 12562628 Surely the authors deliberately emphasized that aspartame is well-known to be a source of formaldehyde, which is an extremely potent, cumulative toxin, with complex, multiple effects on all tissues and organs. This is even more significant, considering that they have already tested aspartame, but not yet released the results: p. 29-32 Table 1: The Ramazzinni Foundation Cancer Program Project of [200] Long-Term Carcinogenicity Bioassays: Agents Studied No. No. of Bioassays Species No. Route of Exposure 108. "Coca-Cola" 4 Rat 1,999 Ingestion, Transplantal Route 109. "Pepsi-Cola" 1 Rat 400 Ingestion 110. Sucrose 1 Rat 400 Ingestion 111. Caffeine 1 Rat 800 Ingestion 112. Aspartame 1 Rat 1,800 Ingestion http://members.nyas.org/events/confe...f_02_0429.html Soffritti said that Coca-Cola showed no carcinogenicity. It may be time to disclose these important aspartame results. Finally, an intripid and much published team in Japan has found DNA damage in 8 tissues from single non-lethal doses of aspartame (near-significant high levels of DNA damage in 5 tissues) and many other additives in groups of just 4 mice: Mutat Res 2002 Aug 26; 519(1-2): 103-19 The comet assay with 8 mouse organs: results with 39 currently used food additives. Sasaki YF, Kawaguchi S, Kamaya A, Oh****a M, Kabasawa K, Iwama K, Taniguchi K, Tsuda S. Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Tamonoki Uwanotai 16-1, Aomori 039-1192, Japan. ; We determined the genotoxicity of 39 chemicals currently in use as food additives. They fell into six categories-dyes, color fixatives and preservatives, preservatives, antioxidants, fungicides, and sweeteners. We tested groups of four male ddY mice once orally with each additive at up to 0.5xLD(50) or the limit dose (2000 mg/kg) and performed the comet assay on the glandular stomach, colon, liver, kidney, urinary bladder, lung, brain, and bone marrow 3 and 24 h after treatment. Of all the additives, dyes were the most genotoxic. Amaranth, Allura Red, New Coccine, Tartrazine, Erythrosine, Phloxine, and Rose Bengal induced dose-related DNA damage in the glandular stomach, colon, and/or urinary bladder. All seven dyes induced DNA damage in the gastrointestinal organs at a low dose (10 or 100 mg/kg). Among them, Amaranth, Allura Red, New Coccine, and Tartrazine induced DNA damage in the colon at close to the acceptable daily intakes (ADIs). Two antioxidants (butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT)), three fungicides (biphenyl, sodium o-phenylphenol, and thiabendazole), and four sweeteners (sodium cyclamate, saccharin, sodium saccharin, and sucralose) also induced DNA damage in gastrointestinal organs. Based on these results, we believe that more extensive assessment of food additives in current use is warranted. PMID: 12160896 http://groups.yahoo.com/group/aspartameNM/message/934 24 recent formaldehyde toxicity [Comet assay] reports: Murray 2002.12.31 rmforall http://groups.yahoo.com/group/aspartameNM/message/935 Comet assay finds DNA damage from sucralose, cyclamate, saccharin in mice: Sasaki YF & Tsuda S Aug 2002: Murray 2003.01.01 rmforall [ Also borderline evidence, in this pilot study of 39 food additives, using test groups of 4 mice, for DNA damage from for stomach, colon, liver, bladder, and lung 3 hr after oral dose of 2000 mg/kg aspartame-- a very high dose. Methanol is the only component of aspartame that can lead to DNA damage. ] http://groups.yahoo.com/group/aspartameNM/message/961 genotoxins, Comet assay in mice: Ace-K, stevia fine; aspartame poor; sucralose, cyclamate, saccharin bad: Y.F. Sasaki Aug 2002: Murray 2003.01.27 rmforall [A detailed look at the data] ] J Toxicol Sci. 2002 Dec; 27 Suppl 1: 1-8. [Genotoxicity studies of stevia extract and steviol by the comet assay] [Article in Japanese] Sekihashi K, Saitoh H, Sasaki Y. Safety Research Institute for Chemical Compounds Co., Ltd., 363-24 Shin-ei, Kiyota-ku, Sapporo 004-0839, Japan. The genotoxicity of steviol, a metabolite of stevia extract, was evaluated for its genotoxic potential using the comet assay. In an in vitro study, steviol at 62.5, 125, 250, and 500 micrograms/ml did not damage the nuclear DNA of TK6 and WTK1 cells in the presence and absence of S9 mix. In vivo studies of steviol were conducted by two independent organizations. Mice were sacrificed 3 and 24 hr after one oral administration of steviol at 250, 500, 1000, and 2000 mg/kg. DNA damage in multiple mouse organs was measured by the comet assay as modified by us. After oral treatment, stomach, colon, liver, kidney and testis DNA were not damaged. The in vivo genotoxicity of stevia extract was also evaluated for its genotoxic potential using the comet assay. Mice were sacrificed 3 and 24 hr after oral administration of stevia extract at 250, 500, 1000, and 2000 mg/kg. Stomach, colon and liver DNA were not damaged. As all studies showed negative responses, stevia extract and steviol are concluded to not have DNA-damaging activity in cultured cells and mouse organs. PMID: 12533916 http://groups.yahoo.com/group/aspartameNM/message/1018 aspartame toxicity coverup increases danger of corporate meltdown: Michael C. Carakostas of Coca-Cola: Murray 2003.08.11 rmforall http://www.isrtp.org/new_members/members1.htm The International Society of Regulatory Toxicology and Pharmacology Carakostas, Michael C., DVM, PhD Director/Scientific & Regulatory Affairs The Coca-Cola Company PO Drawer 1734 Atlanta, GA 30301 T. 404/676-4234 F. 404/676-7166 E-mail: http://www2.coca-cola.com/ourcompany...aspartame.html [photo] Aspartame: The world agrees it's safe By Michael Carakostas, DVM, PhD Director, Scientific and Regulatory Affairs, Coca-Cola It is commendable that Carakostas mentions the core problem, albeit disparagingly, and overlaid with multiple untruths: "During digestion, aspartame yields a very small amount of methanol-- as do many other food substances. The body converts this methanol to formaldehyde, which is instantly converted to formate. Formate is quickly eliminated as carbon dioxide and water." Carakostas deceptively make claims, unsupported by research, that the amount of methanol from aspartame is "very small", that many foods release as much, and that little of the inevitable formaldehyde or formic acid toxic products accumulate in body tissues. This executive, with a PhD in veterinary science, is deceiving people about very serious multiple toxicities. Thus, there is evidence here cited from 1973 to 2004 that research and reviews by immense vested interests about aspartame must be scrutinized with the greatest skepticism. The greatest Internet myth about aspartame is this: "Aspartame is the most thoroughly tested food additive in history." http://groups.yahoo.com/group/aspartameNM/message/857 www.dorway.com: original documents and long reviews of flaws in aspartame toxicity research: Murray 2002.07.31 rmforall http://groups.yahoo.com/group/aspartameNM/message/858 Samuels: Strong: Roberts: Gold: flaws in double-blind studies re aspartame and MSG toxicity: Murray 2002.08.01 rmforall "Survey of aspartame studies: correlation of outcome and funding sources," 1998, unpublished: http://www.dorway.com/peerrev.html Walton found 166 separate published studies in the peer reviewed medical literature, which had relevance for questions of human safety. The 74 studies funded by industry all (100%) attested to aspartame's safety, whereas of the 92 non-industry funded studies, 84 (91%) identified a problem. Six of the seven non-industry funded studies that were favorable to aspartame safety were from the FDA, which has a public record that shows a strong pro-industry bias. Ralph G. Walton, MD, Prof. of Clinical Psychology, Northeastern Ohio Universities, College of Medicine, Dept. of Psychiatry, Youngstown, OH 44501, Chairman, The Center for Behavioral Medicine, Northside Medical Center, 500 Gypsy Lane, P.O. Box 240 Youngstown, OH 44501 330-740-3621 http://www.neoucom.edu/DEPTS/Psychiatry/walton.htm http://groups.yahoo.com/group/aspartameNM/message/622 Gold: Koehler: Walton: Van Den Eeden: Leon: aspartame toxicity: Murray 2001.06.04 rmforall four double-blind studies Headache 1988 Feb; 28(1): 10-4 The effect of aspartame on migraine headache. Koehler SM, Glaros A PMID: 3277925, UI: 88138777 Shirley M. Koehler, Ph.D. Department of Psychology Brooks Rehabilitation Hospital 3599 University Boulevard, South Jacksonville, Florida 32216 (904) 858-7650 Alan Glaros 816-235-2074 They conducted a double-blind study of patients, ages 18-55, who had a medical diagnosis of classical migraines (normally having 1-3 migraines in 4-weeks), who were not on medications (other than analgesics), and who suspected that aspartame had a negative effect on their migraine headaches. The subjects were given 1200 mg daily, aspartame or placebo, for four weeks, about 17 mg/kg. The placebo group had no increase in headaches. Approximately half of the subjects (5 of 11) who took aspartame had a large, statistically significant (p = 0.02), increase in migraine headache frequency, but not in intensity or duration, compared to baseline or placebo. Only 11 of 25 subjects completed the program: 8 dropped out, 4 began new medications, 2 had incomplete records. They were at home. Since 1/3 of the subjects dropped out, they may have been choosing to avoid headaches-- were they unpaid? To achieve statistical signifance with only 11 subjects hints that the incidence rate from aspartame is very high, about 1/2, for migraine cases who believe that they are hurt by aspartame. http://groups.yahoo.com/group/aspartameNM/message/1077 eight depressed people react strongly to aspartame, Prof. Ralph G. Walton, MD, 1993 double-blind study, full text: Murray 2004.04.26 rmforall Walton, RG, "Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population," 1993, with Robert Hudak and Ruth J. Green-Waite, Biological Psychiatry, 34 (1), 13-17. Ralph G. Walton, MD, Prof. of Clinical Psychology, Northeastern Ohio Universities, College of Medicine, Dept. of Psychiatry, Youngstown, OH 44501, Chairman, The Center for Behavioral Medicine, Northside Medical Center, 500 Gypsy Lane, P.O. Box 240 Youngstown, OH 44501 330-740-3621 http://www.neoucom.edu/DEPTS/Psychiatry/walton.htm Eight depressed patients, ages 24-60, and five non-depressed controls, ages 24-56, employed at the hospital, were given for 7 days either aspartame or a placebo, and then after a 3 day break, given the opposite. Each got 2100 mg aspartame daily, 30 mg/kg bodyweight, equal to 10-12 cans of diet soda daily, about a gallon. Despite the very small number of subjects, the results were dramatic and statistically significant. The eight depressed patients reported with aspartame, compared to placebo, much higher levels of nervousness, trouble remembering, nausea, depression, temper, and malaise. (For each symptom, p0.01) The five normals did not report strong enough differences between aspartame and placebo to be significant. Initially, the study was to be on a group of 40, but was halted by the Institutional Review Board because of severe reactions among 3 of the depressed patients. Again, statistical significance with only 8 depressed patients: "In this study, patients most often began to report significant symptoms after day 2 or 3." The incidence rate is very high, indeed, about 1/3. The most common symptoms are entirely typical of thousands of case histories. Stephen K. Van Den Eeden, T.D. Koepsell, W.T. Longstreth, Jr, G. van Belle, J.R. Daling, B. McKnight, "Aspartame ingestion and headaches: a randomized crossover trial," 1994, Neurology, 44, 1787-93 Steven K. Van Den Eeden,PhD 550-450-2202 Division of Research, Kaiser Permanente Medical Care Program 3505 Broadway, Oakland, CA 94611-5714 http://www.dor.kaiser.org/dorhtml/in...Den_Eeden.html In their introduction, they comment: "In addition, the FDA had received over 5,000 complaints as of July, 1991 in a passive surveillance system to monitor adverse side effects. (17) Neurologic problems constitute the primary complaints in these and several other case series, with headaches accounting for 18 to 45 %,depending on the case series reported. (17-19)" Subjects, ages 18-57, were recruited who believed they got headaches from aspartame, but were otherwise mentally and physically healthy. They were paid $ 15 total, and were at home. Of the 44 subjects, 32 contributed data to the 38-day trials: a week of inert placebo, a week of either aspartame or placebo, followed by a week of the opposite, and then this two-week cycle repeated. The daily dose was about 30 mg/kg. "The proportion of days subjects reported having a headache was higher during aspartame treatment compared with placebo treatment (aspartame = 0.33, placebo = 0.24; p = 0.04) (table 5)". Of the 12 subjects not included in the data, 7 reported adverse symptoms before withdrawing. Again, statistical significance with a moderate number of healthy subjects, willing to be recruited by a newspaper ad, who believed aspartame hurt them. The number of headaches for each subject for each treatment week are given: it appears that 4 subjects had the strongest increase in headaches from the run-in week or placebo week to their first week on aspartame, jumping from 0 to 5, 1 to 6, 1 to 4, 0 to 5 headaches per week. So, about 4 of the 44 healthy people recruited for the study, who believed aspartame hurt them, had a stong increase in headaches from the first week of daily asparame exposure, while 7 reported adverse symptoms before leaving, a total of 11 out of 44, an incidence ratio of 1/4. This is sky high, if we consider that, if the incidence ratio for the about two hundred million users in the USA is 1 of 100, that is 2 million cases. It is plausible that the incidence ratio lies between 1 and 10 out of 100 for continuous daily exposure. These three flames should have set off alarm bells, with extensive follow-up studies and much more careful study of thousands of case histories. But these little flares were adroitly smothered by thick blankets of industry funded fluff: http://groups.yahoo.com/group/aspartameNM/message/623 Simmons: Gold: Schiffman: Spiers: aspartame toxicity: Murray 2001.06.04 rmforall two double-blind studies http://www.dorway.com/tldaddic.html 5-page review Roberts HJ Aspartame (NutraSweet) addiction. Townsend Letter 2000 Jan; http://www.sunsentpress.com/ Sunshine Sentinel Press P.O.Box 17799 West Palm Beach, FL 33416 800-814-9800 561-588-7628 561-547-8008 fax http://groups.yahoo.com/group/aspartameNM/message/669 1038-page medical text "Aspartame Disease: An Ignored Epidemic" published May 30 2001 $ 60.00 postpaid data from 1200 cases available at http://www.amazon.com over 600 references from standard medical research http://groups.yahoo.com/group/aspartameNM/message/790 Moseley: review Roberts "Aspartame Disease: An Ignored Epidemic": Murray 2002.02.07 rmforall Roberts, Hyman J., 1924- , Useful insights for diagnosis, treatment and public heath: an updated anthology of original research, 2002, 798 pages, aspartame disease, pages 627-685, 778-780 http://groups.yahoo.com/group/aspartameNM/message/859 Roberts: the life work of a brilliant clinician: aspartame toxicity: Murray 2002.08.02 rmforall http://groups.yahoo.com/group/aspartameNM/message/1070 critique of aspartame review, French Food Safety Agency AFSSA 2002.05.07 aspartamgb.pdf (18 pages, in English), Martin Hirsch: Murray 2004.04.13 http://groups.yahoo.com/group/aspartameNM/message/957 safety of aspartame Part 1/2 12.4.2: EC HCPD-G SCF: Murray 2003.01.12 rmforall EU Scientific Committee on Food, a whitewash http://groups.yahoo.com/group/aspartameNM/message/1045 http://www.holisticmed.com/aspartame...2-response.htm Mark Gold exhaustively critiques European Commission Scientific Committee on Food re aspartame ( 2002.12.04 ): 59 pages, 230 references http://groups.yahoo.com/group/aspartameNM/message/989 On 2003.04.10 the European Union Parliament voted 440 to 20 to approve sucralose, limit cyclamates & reevaluate aspartame & stevia: Murray 2003.04.12 rmforall There is an astonishing amount of positive research about stevia, banned in the EU, and not allowed to be claimed as a sweetener in the USA: http://www.eatright.org/Nutritive(1).pdf J Am Diet Assoc. 2004 Feb; 104(2): 255-75. Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners. American Dietetic Association. http://groups.yahoo.com/group/aspartameNM/message/1068 critique of aspartame review by American Dietetic Association Feb 2004, Valerie B. Duffy & Madeleine J. Sigman-Grant: Murray 2004.05.14 rmforall http://www.dorway.com ( David O. Rietz, died 2003 ) over 12,000 print pages Mission-Possible-USA Betty Martini 770-242-2599 http://www.dorway.com/asprlink.html many links http://www.dorway.com/nslawsuit.txt Jeff Martin, Attorney http://www.dorway.com/doctors.txt What many informed doctors are saying/have said about aspartame Mary Nash Stoddard Toxicology Sourcebook: "Deadly Deception Story of Aspartame" Aspartame Consumer Safety Network and Pilot Hotline [since 1987] PO Box 780634 Dallas TX 75378-0634 phone: 214.387.4001 http://www.aspartamesafety.com http://www.sweetpoison.com/ http://www.sweetpoison.com/food-additives-to-avoid.html Dr. Janet Starr Hull, PhD, CN http://groups.yahoo.com/group/aspartameNM/message/805 Ive: UK Daily Mirror Magazine: aspartame toxicity: Murray 2002.02.18 rmforall http://groups.yahoo.com/group/aspartameNM/message/1016 President Bush & formaldehyde (aspartame) toxicity: Ramazzini Foundation carcinogenicity results Dec 2002: Soffritti: Murray 2003.08.03 rmforall http://groups.yahoo.com/group/aspartameNM/message/874 re "dry drunk": Bisbort: danger to President Bush from aspartame toxicity: Murray: 2002.02.24 2002.09.29 rmforall http://groups.yahoo.com/group/aspartameNM/message/1065 politicians and celebrities hooked on diet sodas (aspartame): Murray 2004.03.24 rmforall http://groups.yahoo.com/group/aspartameNM/message/1101 John Edwards gives up Diet Coke: The Cult of Diet Coke, Eric Gillin: Murray 2004.07.12 rmforall http://groups.yahoo.com/group/aspartameNM/message/1102 John Edwards still drinks Diet Coke (aspartame): TIME Europe July 19 issue: Murray 2004.07.12 rmforall http://groups.yahoo.com/group/aspartameNM/message/876 hyperthyroidism (Graves disease) in George and Barbara Bush, 1991-- aspartame toxicity? Roberts 1997: Murray 2002.10.09 rmforall http://www.dorway.com/upipart1.txt http://groups.yahoo.com/group/aspartameNM/message/262 aspartame expose 96K Oct 1987 Part 1/3: Gregory Gordon, UPI reporter: Murray 2000.07.10 rmforall http://www.dorway.com/enclosur.html http://groups.yahoo.com/group/aspartameNM/message/53 aspartame history Part 1/4 1964-1976: Gold: Murray 1999.11.06 rmforall http://groups.yahoo.com/group/aspartameNM/message/928 revolving door, Monsanto, FDA, EPA: NGIN: Murray 2002.12.23 rmforall http://groups.yahoo.com/group/aspartameNM/message/841 RTM: Merisant Co., MSD Capital, Dell Computer Corp., NutraSweet Co., JW Childs Assc.: aspartame-neotame toxicity 2002.07.10 rmforall http://google.com gives 247,000 websites for "aspartame" , with the top 8 of 10 listings being anti-aspartame, while http://groups.google.com finds on 700 MB of posts from 20 years of Usenet groups, 92,300 posts, the top 10 being anti-aspartame. http://news.google.com 33 recent aspartame items from 4500 sources. http://www.AllTheWeb.com gives 43,913, the top 8 of 10 anti. http://teoma.com/index.asp gives 78,200 websites, top 8 of 10 anti. http://www.ncbi.nlm.nih.gov/PubMed lists 763 aspartame items. Many scientific studies and case histories report: * headaches * many body and joint pains (or burning, tingling, tremors, twitching, spasms, cramps, stiffness, numbness, difficulty swallowing) * fever, fatigue, swollen glands * "mind fog", "feel unreal", poor memory, confusion, anxiety, irritability, depression, mania, insomnia, dizziness, slurred speech, sexual problems, poor vision, hearing (deafness, tinnitus), or taste * red face, itching, rashes, allergic dermatitis, hair loss, burning eyes or throat, dry eyes or mouth, mouth sores, burning tongue * obesity, bloating, edema, anorexia, poor appetite or excessive hunger or thirst * breathing problems, shortness of breath * nausea, diarrhea or constipation * coldness * sweating * racing heart, low or high blood pressure, erratic blood sugar levels * hypothryroidism or hyperthyroidism * seizures * birth defects * brain cancers * addiction * aggrivates diabetes, autism, allergies, lupus, ADHD, fibromyalgia, chronic fatigue syndrome, multiple chemical sensitivity, multiple sclerosis, pseudotumor cerebri and interstitial cystitis (bladder pain). ************************************************** ********* http://groups.yahoo.com/group/aspartameNM/message/870 Aspartame: Methanol and the Public Interest 1984: Monte: Murray 2002.09.23 rmforall Dr. Woodrow C. Monte Aspartame: methanol, and the public health. Journal of Applied Nutrition 1984; 36 (1): 42-54. (62 references) Professsor of Food Science [retired 1992] Arizona State University, Tempe, Arizona 85287 The methanol from 2 L of diet soda, 5.6 12-oz cans, 20 mg/can, is 112 mg, 10% of the aspartame. The EPA limit for water is 7.8 mg daily for methanol (wood alcohol), a deadly cumulative poison. Many users drink 1-2 L daily. The reported symptoms are entirely consistent with chronic methanol toxicity. (Fresh orange juice has 34 mg/L, but, like all juices, has 16 times more ethanol, which strongly protects against methanol.) "The greater toxicity of methanol to man is deeply rooted in the limited biochemical pathways available to humans for detoxification. The loss of uricase (EC 1.7.3.3.), formyl-tetrahydrofolate synthetase (EC 6.3.4.3.) (42) and other enzymes (18) during evolution sets man apart from all laboratory animals including the monkey (42). There is no generally accepted animal model for methanol toxicity (42, 59). Humans suffer "toxic syndrome" (54) at a minimum lethal dose of 1 gm/kg, much less than that of monkeys, 3-6 g/kg (42, 59). The minimum lethal dose of methanol in the rat, rabbit, and dog is 9.5, 7.0 , and 8.0 g/kg, respectively (43); ethyl alcohol is more toxic than methanol to these test animals (43)." "Fruit and vegetables contain pectin with variable methyl ester content. However, the human has no digestive enzymes for pectin (6, 25) particularly the pectin esterase required for its hydrolysis to methanol (26). Fermentation in the gut may cause disappearance of pectin (6) but the production of free methanol is not guaranteed by fermentation (3). In fact, bacteria in the colon probably reduce methanol directly to formic acid or carbon dioxide (6) (aspartame is completely absorbed before reaching the colon). Heating of pectins has been shown to cause virtually no demethoxylation; even temperatures of 120 deg C produced only traces of methanol (3). Methanol evolved during cooking of high pectin foods (7) has been accounted for in the volatile fraction during boiling and is quickly lost to the atmosphere (49). Entrapment of these volatiles probably accounts for the elevation in methanol levels of certain fruits and vegetable products during canning (31, 33)." "An alcoholic consuming 1500 calories a day from alcoholic sources alone may consume between 0 and 600 mg of methanol each day depending on his choice of beverages (Table 1)...." Table 1 lists red wine as having 128 mg/l methanol, about one part in ten thousand. Recent research [see links at end of post] supports his focus on the methanol to formaldehyde toxic process: "The United States Environmental Protection Agency in their Multimedia Environmental Goals for Environmental Assessment recommends a minimum acute toxicity concentration of methanol in drinking water at 3.9 parts per million, with a recommended limit of consumption below 7.8 mg/day (8). This report clearly indicates that methanol: "...is considered a cumulative poison due to the low rate of excretion once it is absorbed. In the body, methanol is oxidized to formaldehyde and formic acid; both of these metabolites are toxic." (8)... Recently the toxic role of formaldehyde (in methanol toxicity) has been questioned (34). No skeptic can overlook the fact that, metabolically, formaldehyde must be formed as an intermediate to formic acid production (54). Formaldehyde has a high reactivity which may be why it has not been found in humans or other primates during methanol poisoning (59).... If formaldehyde is produced from methanol and does have a reasonable half life within certain cells in the poisoned organism the chronic toxicological ramifications could be grave. Formaldehyde is a known carcinogen (57) producing squanous-cell carcinomas by inhalation exposure in experimental animals (22). The available epidemiological studies do not provide adequate data for assessing the carcinogenicity of formaldehyde in man (22, 24, 57). However, reaction of formaldehyde with deoxyribonucleic acid (DNA) has resulted in irreversible denaturation that could interfere with DNA replication and result in mutation (37)..." http://www.dorway.com/barua.html Dr. J. Barua (ophthalmic surgeon), Dr. Arun Bal (surgeon) Emerging facts about aspartame. Journal Of The Diabetic Association Of India 1995; 35 (4): (79 references) "...the total amount of methanol absorbed will be approximately 10% of aspartame ingested. An EPA assessment of methanol states that methanol, 'is considered a cumulative poison due to the low rate of excretion once it is absorbed. The absorbed methanol is then slowly converted to formaldehyde...'" "Reaction of formaldehyde with DNA has been observed, by spectrophotometry and electron microscopy, to result in irreversible denaturation." "DKP [from aspartame] has been implicated in the occurence of brain tumors." ************************************************** ************ http://groups.yahoo.com/group/aspartameNM/message/939 aspartame (aspartic acid, phenylalanine) binding to DNA: Karikas July 1998: Murray 2003.01.05 rmforall Karikas GA, Schulpis KH, Reclos GJ, Kokotos G Measurement of molecular interaction of aspartame and its metabolites with DNA. Clin Biochem 1998 Jul; 31(5): 405-7. Dept. of Chemistry, University of Athens, Greece http://www.chem.uoa.gr K.H. Schulpis ; G.J. Reclos http://groups.yahoo.com/group/aspartameNM/message/960 aspartame & MSG: possible role in autoimmune hepatitis: Prandota Jan 2003: Murray 2003.01.15 rmforall http://groups.yahoo.com/group/aspartameNM/message/938 aspartame harms mice brain cells: Hetle & Eltervaag: 2001 thesis abstract: Sonnewald 1995 study, full text: Murray 2003.01.05 rmforall http://groups.yahoo.com/group/aspartameNM/message/346 WebMD: Barclay: Barth: survey shows aspartame hurts memory in students 2000.11.09 Timothy M. Barth Department of Psychology Texas Christian University TCU Box 298920 Fort Worth, TX 76129 Chairman, Physiological Psychology 817-921-7410 http://groups.yahoo.com/group/aspartameNM/message/760 Kovatsi L, Tsouggas M The effect of oral aspartame administration on the balance of magnesium in the rat. Magnes Res 2001 Sep;14(3): 189-94. Laboratory of Forensic Medicine & Toxicology, Faculty of Medicine Aristotle University of Thessaloniki, Greece http://groups.yahoo.com/group/aspartameNM/message/943 aspartame, cell phones, brain cancer July 1999 Hardell: Murray 2003.01.09 rmforall http://www.medscape.com/MedGenMed/braintumors Lennart Hardell, M.D., PhD, in 1999 reported in Sweden that both cell phone use and heavy aspartame use correlate with increased brain cancers +46 19 602 15 46 http://groups.yahoo.com/group/aspartameNM/message/31 Wurtman: aspartame & seizures 1985.11.09: Murray 1999.10.30 Wurtman RJ Aspartame: possible effect on seizure susceptibility. Lancet 1985 Nov 9; 2(8463): 1060. Richard J. Wurtman, Ph.D. 617-253-3091 Professor of Neuroscience Prof. of Health Sciences and Technology Massachusetts Institute of Technlogy Cambridge, Mass. 02139 http://www.truthinlabeling.org/ Truth in Labeling Campaign [MSG] Adrienne Samuels, PhD The toxicity/safety of processed free glutamic acid (MSG): a study in suppression of information. Accountability in Research 1999; 6: 259-310. 52-page review P.O. Box 2532 Darien, Illinois 60561 858-481-9333 Russell L. Blaylock, MD 601-982-1175 Madison, Mississippi "Excitotoxins: The Taste that Kills", 1977, 298 p., 493 references. "Health and Nutrition Secrets that can save your life", 2002, 459 p., 558 + 30 references, $ 30 http://www.russellblaylockmd.com/ George R. Schwartz, MD "In Bad Taste: The MSG Syndrome", 1988 http://www.healthpress.com/ PO Box 37470 Albuquerque, NM 87176 505-888-1394 Kathleen Frazier, Publisher ************************************************** ************ http://www.readthelabel.org.uk/ Additives Survivors' Network (UK) Geoff Brewer http://www.chem.ox.ac.uk/mom/aspartame/aspartame.html http://www.chm.bris.ac.uk/webproject...ers/sarah.html Sarah Rogers http://www.react.ie/Health/Nutrition/Aspartame.htm Ireland http://members.tripod.com/~mission_p...nd_branch.html http://www.aspartame.ca/indexa.html John T. Linnell http://www.cybernaute.com/earthconce...taMalcache.htm http://www.fedupwithfoodadditives.info/ Australia FAILSAFE diet http://www.bradymax.com/nzaa/ New Zealand http://www.reseauproteus.net/therapi.../aspartame.htm France http://ww2.grn.es/avalls/aspa1.htm Spain http://www.geocities.com/HotSprings/Falls/8669/ Brazil http://www.phd.com.br/aspartame.htm http://hem.passagen.se/mission.possible.sweden/ http://home.online.no/~dusan/foods/aspartame.html Norway http://www.ostara.org/aspartam/#menue Germany http://www.aspartaam.nl/info/product.html Holland, in Dutch http://www.laleva.org/ Italy 9 languages http://www.laleva.cc/alimenti/alimenti.html aspartame vs stevia 4.17.03 http://users.westnet.gr/~cgian/aspartame.htm Greece http://www.cseindia.org/html/cola-indepth/index.htm India ************************************************** ************ http://www.vegsource.com extensive vegan information htttp://www.drmcdougall.com practical, delicious healthy diet guidance http://www.vegsource.com/articles/kradjian_milk.htm Robert Kradjian MD Discusses Milk http://groups.yahoo.com/group/aspartameNM/message/971 Joel Fuhrman critique of Atkins diet in "Eat To Live": Murray 2003.03.01 rmforall http://www.hyp.ac.uk/cash/index.htm Consensus Action on Salt and Health Substitute stevia (at health food stores). Avoid all products with aspartame and MSG. Gradually reduce alcohol, sugar, caffeine (coffee, cocoa, and teas), meat, fish, eggs, milk, butter, and cheese, hydrogenated oils, trans fats, food additives and colors, fluoride, city water, salt and sodium. Enjoy organic rice, potatoes, vegetables, fruits, beans, nuts, almond butter, garlic, tumeric, with modest use of soy products and sprouted grain breads, flax seed and olive oils, vitamins and minerals, 4-8 1,000 mg fish oil capsules, and fill your jugs with deionized water. ************************************************** ************ |
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