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#51
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What would happen if we stopped Vaccinations....
On May 22, 9
Are you intentionally trying to be dishonest with that article? That not true and you know it . The real question is are you? "Investigators in these trials have hit their mark soundly: the vaccine showed significant efficacy against anogenital and cervical lesions related to vaccine type in women with no evidence of previous exposure to vaccine-specific types; the vaccine also appeared to be safe." You accurately quoted That. That means it is safe and effective. that's your opinion and it is not shared by the authors of the article "Why is vaccine efficacy modest in the entire cohort? One factor is the apparent lack of efficacy among subjects with evidence of previous exposure to HPV types included in the vaccine." Well you quoted that right?? This simply states that the vaccine is not very effective in women that have had previous exposure to HPV. Which is why they should get the vaccine before they begin sexual activity. ....Thats the distortion the authors say nothing like that. I asume you either do not understand what you read or do not care to translate it correctly. Maybe you got that from a commercial or some other source. "What can be inferred from these data about the potential effect of vaccination among girls 11 and 12 years of age? The FUTURE trials did not enroll subjects in this age group. Within both trials, subgroups of subjects with no evidence of previous exposure to relevant vaccine HPV types were evaluated separately for vaccine efficacy. In these subgroups, efficacy of nearly 100% against all grades of cervical intraepithelial neoplasia and adenocarcinoma in situ related to vaccine HPV types was reported in both trials." Lastly, this says there is a nearly 100% effectiveness in the groups that the vaccine would be targeting. Girls that had no previous exposure to HPV. I find it amazing how you can attempt to twist that article into an attack on the effectiveness of HPV vaccine in women that have had no previous exposure to HPV. I won't be replying to this thread again, on the topic of HPV at least, as it is redundant. You have posted no information that the vaccine is harmful, or even ineffective, in the least. I don't really know why you don't like the vaccine and I don't care. I just hope that not one person will believe the tripe you have posted. Lets clear up your distortions from the same article "Given the rarity of incident cervical cancer, preinvasive cervical lesions with high invasive potential are used in contemporary studies as surrogate outcomes for cervical cancer. Adenocarcinoma in situ is a rare lesion widely considered to be a precursor of cancer. Cervical intraepithelial neoplasia is graded from 1 to 3 on the basis of histopathological criteria. Grade 1 cervical intraepithelial neoplasia indicates the presence of active HPV infection and is not considered to be precancerous; current guidelines discourage treatment of this condition.7,8 Grade 2 cervical intraepithelial neoplasia is treated in most women but is not an irrefutable cancer surrogate, since up to 40% of such lesions regress spontaneously9; current guidelines suggest that some young women with such lesions do not need to be treated.7,8 Grade 3 cervical intraepithelial neoplasia, on the other hand, has the lowest likelihood of regression and the strongest potential to be invasive. The Food and Drug Administration (FDA) considers grade 2 and 3 cervical intraepithelial neoplasia and adenocarcinoma in situ to be acceptable surrogate outcomes for cervical cancer; other observers consider grade 3 cervical intraepithelial neoplasia and adenocarcinoma in situ to be more appropriate surrogates.9 " Now thats a little technical but what it says is that stage 3 lessions are the most relevant surrogate for cancer. But the article goes on to say ..........."'In the larger FUTURE II trial,6 rates of grade 2 or 3 cervical intraepithelial neoplasia or adenocarcinoma in situ were 1.3 in vaccinated women and 1.5 in unvaccinated women, an efficacy of 17%. In analyses by lesion type, the efficacy appears to be significant only for grade 2 cervical intraepithelial neoplasia; no efficacy was demonstrable for grade 3 cervical intraepithelial neoplasia or adenocarcinoma in situ.'" NEJM MAy 10 2007 Now as you say this article does not question the effectiveness of this vaccine lets see what the authors say from same article............. "On one hand, the vaccine has high efficacy against certain HPV types that cause life-threatening disease, and it appears to be safe; delaying vaccination may mean that many women will miss an opportunity for long-lasting protection. On the other hand, a cautious approach may be warranted in light of important unanswered questions about overall vaccine effectiveness, duration of protection, and adverse effects that may emerge over time. HPV vaccination has the potential for profound public health benefit if the most optimistic scenario of effectiveness is realized. " link here http://content.nejm.org/cgi/content/full/356/19/1991 I do not like or dislike this vaccine . I perfer that benefit be shown before using 11 year olds as a test tube. You prefer that this vaccine be given before it shows a real ability to prevent cancer. It might and it might not. I wonder why you set such a low standard. I encourage people to look at the article and draw their own conclusions. I have no vested interest in this product. You write as if you have. thanks Vince |
#52
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What would happen if we stopped Vaccinations....
On May 22, 9:34 am, wrote:
On May 22, 12:58 am, bigvince wrote: On May 21, - Are you intentionally trying to be dishonest with that article? These are direct quotes from your article..... "Investigators in these trials have hit their mark soundly: the vaccine showed significant efficacy against anogenital and cervical lesions related to vaccine type in women with no evidence of previous exposure to vaccine-specific types; the vaccine also appeared to be safe." That means it is safe and effective. "Why is vaccine efficacy modest in the entire cohort? One factor is the apparent lack of efficacy among subjects with evidence of previous exposure to HPV types included in the vaccine." This simply states that the vaccine is not very effective in women that have had previous exposure to HPV. Which is why they should get the vaccine before they begin sexual activity. "What can be inferred from these data about the potential effect of vaccination among girls 11 and 12 years of age? The FUTURE trials did not enroll subjects in this age group. Within both trials, subgroups of subjects with no evidence of previous exposure to relevant vaccine HPV types were evaluated separately for vaccine efficacy. In these subgroups, efficacy of nearly 100% against all grades of cervical intraepithelial neoplasia and adenocarcinoma in situ related to vaccine HPV types was reported in both trials." Lastly, this says there is a nearly 100% effectiveness in the groups that the vaccine would be targeting. Girls that had no previous exposure to HPV. I find it amazing how you can attempt to twist that article into an attack on the effectiveness of HPV vaccine in women that have had no previous exposure to HPV. I won't be replying to this thread again, on the topic of HPV at least, as it is redundant. You have posted no information that the vaccine is harmful, or even inneffective, in the least. I don't really know why you don't like the vaccine and I don't care. I just hope that not one person will believe the tripe you have posted. And here the original posting ...from NEJM article.. "HPV Vaccination - More Answers, More Questions" George F. Sawaya, M.D., and Karen Smith-McCune, M.D., Ph.D. "In this issue of the Journal, reports on two large, ongoing, randomized, placebo-controlled trials show the effect of this vaccine on important clinical outcomes," ....the article places the 14% reduction in perspective....."Given the rarity of incident cervical cancer, preinvasive cervical lesions with high invasive potential are used in contemporary studies as surrogate outcomes for cervical cancer" now mare you do not have to be a math major to realize that 14% of a rare cancer is a very small cancer reduction. The 14% reduction small and it is also unproven.. ......now the rest is technical and needed to understand the science......again from the article ....... "Grade 1 cervical intraepithelial neoplasia indicates the presence of active HPV infection and is not considered to be precancerous; current guidelines discourage treatment of this condition.7,8 Grade 2 cervical intraepithelial neoplasia is treated in most women but is not an irrefutable cancer surrogate, since up to 40% of such lesions regress spontaneously9; current guidelines suggest that some young women with such lesions do not need to be treated.7,8 Grade 3 cervical intraepithelial neoplasia, on the other hand, has the lowest likelihood of regression and the strongest potential to be invasive"...... Let me help you the best marker of which lessions will become cancerous are grade 3 lessions they are the best surrogate. the studies showed a 17% reduction in lessions but again from the journal ..... "an efficacy of 17%. In analyses by lesion type, the efficacy appears to be significant only for grade 2 cervical intraepithelial neoplasia; no efficacy was demonstrable for grade 3 cervical intraepithelial neoplasia or adenocarcinoma in situ."....... In other words no evidence that this vaccine will prevent any cancer as it has shown no effect on the best surrogate. again from the article..."If grade 3 cervical intraepithelial neoplasia or adenocarcinoma in situ were the most relevant outcome, evidence was insufficient to infer the effectiveness of vaccination." the article balances the hope that this vaccine MAY be effective with caution ..., 'a cautious approach may be warranted in light of important unanswered questions about overall vaccine effectiveness, duration of protection, and adverse effects that may emerge over time.' http://content.nejm.org/cgi/content/full/356/19/1991 Mark I to mandate an product that has not been proven is the most irresponsible act. As you could care less as to facts I encourage others to read the Journal article. Thanks Vince |
#53
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What would happen if we stopped Vaccinations....
bigvince wrote:
On May 22, 8:13 am, Mark Probert wrote: bigvince wrote: On May 21, - - Show quoted text - Which means that a young woman who has had the vaccine has a 14% less chance of developing a precancerous lesion. Which means.... "So that 14% less of a chance isn't worth it? That's an extra 14 lives out of 100. I would say it is well worth the effort." Cancer and precancerous leisons often don't appear for many years so it's premature to conclude that the vaccine results in a 14% decline in precancer signs. Now not one of the statements you have made shows any basis to prove that HPV vaccine will prevent any cancers and it is in the realm of possibility that it could increase cancer deaths by allowing more aggresive viruses to replace those which this product claims to prevent. So lets actually look at the science before we turn 11 year olds into test tubes...from NEJM article.. "HPV Vaccination - More Answers, More Questions" George F. Sawaya, M.D., and Karen Smith-McCune, M.D., Ph.D. "In this issue of the Journal, reports on two large, ongoing, randomized, placebo-controlled trials show the effect of this vaccine on important clinical outcomes," ....the article places the 14% reduction in perspective....."Given the rarity of incident cervical cancer, preinvasive cervical lesions with high invasive potential are used in contemporary studies as surrogate outcomes for cervical cancer" now mare you do not have to be a math major to realize that 14% of a rare cancer is a very small cancer reduction. The 14% reduction small and it is also unproven.. ......now the rest is technical and needed to understand the science......again from the article ....... "Grade 1 cervical intraepithelial neoplasia indicates the presence of active HPV infection and is not considered to be precancerous; current guidelines discourage treatment of this condition.7,8 Grade 2 cervical intraepithelial neoplasia is treated in most women but is not an irrefutable cancer surrogate, since up to 40% of such lesions regress spontaneously9; current guidelines suggest that some young women with such lesions do not need to be treated.7,8 Grade 3 cervical intraepithelial neoplasia, on the other hand, has the lowest likelihood of regression and the strongest potential to be invasive"...... Let me help you the best marker of which lessions will become cancerous are grade 3 lessions they are the best surrogate. the studies showed a 17% reduction in lessions but again from the journal ..... "an efficacy of 17%. In analyses by lesion type, the efficacy appears to be significant only for grade 2 cervical intraepithelial neoplasia; no efficacy was demonstrable for grade 3 cervical intraepithelial neoplasia or adenocarcinoma in situ."....... In other words no evidence that this vaccine will prevent any cancer as it has shown no effect on the best surrogate. again from the article..."If grade 3 cervical intraepithelial neoplasia or adenocarcinoma in situ were the most relevant outcome, evidence was insufficient to infer the effectiveness of vaccination." the article balances the hope that this vaccine MAY be effective with caution ..., 'a cautious approach may be warranted in light of important unanswered questions about overall vaccine effectiveness, duration of protection, and adverse effects that may emerge over time.' http://content.nejm.org/cgi/content/full/356/19/1991 Mark I to mandate an product that has not been proven is the most irresponsible act. As you could care less as to facts I encourage others to read the Journal article. Thanks Vince Stra wman asshole. I care about facts, not highly edited crap.- Hide quoted text - - Show quoted text - You have no concern about facts ,honest discussion of the science ,or any other obstacle to your agenda ...Nor have you any concern for those who may suffer serious side effects from this product. Again address the science you can not and you will not. Publish the parts of the article that I "edited' explain to me how you know that a vaccine that has not been shown to reduce the best marker of cervical cancer ;state 3 lessions is "proven to prevent cancer" You said that it reduced cancer show some evidence. Not the used car salesman desciption of the facts you prefer. Or do what an attorney does when the facts are against him "holler and bang the table' Thanks Vince Again anyone interested in an honest appraisal of the science behind this product should read for themselfs the New England Journal of Medicine articlehttp://content.nejm.org/cgi/content/full/356/19/1991 relie on good info to make your decissions. Thanks Vince The AmazingGuffy said: Are you intentionally trying to be dishonest with that article? These are direct quotes from your article..... "Investigators in these trials have hit their mark soundly: the vaccine showed significant efficacy against anogenital and cervical lesions related to vaccine type in women with no evidence of previous exposure to vaccine-specific types; the vaccine also appeared to be safe." That means it is safe and effective. "Why is vaccine efficacy modest in the entire cohort? One factor is the apparent lack of efficacy among subjects with evidence of previous exposure to HPV types included in the vaccine." This simply states that the vaccine is not very effective in women that have had previous exposure to HPV. Which is why they should get the vaccine before they begin sexual activity. "What can be inferred from these data about the potential effect of vaccination among girls 11 and 12 years of age? The FUTURE trials did not enroll subjects in this age group. Within both trials, subgroups of subjects with no evidence of previous exposure to relevant vaccine HPV types were evaluated separately for vaccine efficacy. In these subgroups, efficacy of nearly 100% against all grades of cervical intraepithelial neoplasia and adenocarcinoma in situ related to vaccine HPV types was reported in both trials." Lastly, this says there is a nearly 100% effectiveness in the groups that the vaccine would be targeting. Girls that had no previous exposure to HPV. I find it amazing how you can attempt to twist that article into an attack on the effectiveness of HPV vaccine in women that have had no previous exposure to HPV. I won't be replying to this thread again, on the topic of HPV at least, as it is redundant. You have posted no information that the vaccine is harmful, or even inneffective, in the least. I don't really know why you don't like the vaccine and I don't care. I just hope that not one person will believe the tripe you have posted. ----- So, Biggie....why are you so selectively editing to change the meaning of the article? Doesn't fit your anti-vac liar agenda, eh? I do not play games with anyone who is intellectually dishonest as you have been shown to be. I was being Mr. Niceguy to your stupidity. Now, you have been outed. |
#54
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What would happen if we stopped Vaccinations....
bigvince wrote:
On May 22, 9:34 am, wrote: On May 22, 12:58 am, bigvince wrote: On May 21, - Are you intentionally trying to be dishonest with that article? These are direct quotes from your article..... "Investigators in these trials have hit their mark soundly: the vaccine showed significant efficacy against anogenital and cervical lesions related to vaccine type in women with no evidence of previous exposure to vaccine-specific types; the vaccine also appeared to be safe." That means it is safe and effective. "Why is vaccine efficacy modest in the entire cohort? One factor is the apparent lack of efficacy among subjects with evidence of previous exposure to HPV types included in the vaccine." This simply states that the vaccine is not very effective in women that have had previous exposure to HPV. Which is why they should get the vaccine before they begin sexual activity. "What can be inferred from these data about the potential effect of vaccination among girls 11 and 12 years of age? The FUTURE trials did not enroll subjects in this age group. Within both trials, subgroups of subjects with no evidence of previous exposure to relevant vaccine HPV types were evaluated separately for vaccine efficacy. In these subgroups, efficacy of nearly 100% against all grades of cervical intraepithelial neoplasia and adenocarcinoma in situ related to vaccine HPV types was reported in both trials." Lastly, this says there is a nearly 100% effectiveness in the groups that the vaccine would be targeting. Girls that had no previous exposure to HPV. I find it amazing how you can attempt to twist that article into an attack on the effectiveness of HPV vaccine in women that have had no previous exposure to HPV. I won't be replying to this thread again, on the topic of HPV at least, as it is redundant. You have posted no information that the vaccine is harmful, or even inneffective, in the least. I don't really know why you don't like the vaccine and I don't care. I just hope that not one person will believe the tripe you have posted. And here the original posting ...from NEJM You mean your highly selective andedited version to change the meaning. Intellectual dishonesty. |
#55
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What would happen if we stopped Vaccinations....
"Mark Probert" wrote Intellectual dishonesty. You are a fine example. http://www.humanticsfoundation.com/sandraprobert.htm |
#56
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What would happen if we stopped Vaccinations....
"Jan Drew" wrote:
"Mark Probert" wrote Intellectual dishonesty. You are a fine example. http://www.humanticsfoundation.com/sandraprobert.htm Adding nothing to a thread: KACHING!! - $1 -- Peter Bowditch aa #2243 The Millenium Project http://www.ratbags.com/rsoles Australian Council Against Health Fraud http://www.acahf.org.au Australian Skeptics http://www.skeptics.com.au To email me use my first name only at ratbags.com |
#57
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What would happen if we stopped Vaccinations....
"Jan Drew" wrote: "Mark Probert" wrote Intellectual dishonesty. You are a fine example. http://www.humanticsfoundation.com/sandraprobert.htm |
#58
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What would happen if we stopped Vaccinations....
"Jan Drew" wrote:
"Jan Drew" wrote: "Mark Probert" wrote Intellectual dishonesty. You are a fine example. http://www.humanticsfoundation.com/sandraprobert.htm KACHING!! - $1 adding nothing -- Peter Bowditch aa #2243 The Millenium Project http://www.ratbags.com/rsoles Australian Council Against Health Fraud http://www.acahf.org.au Australian Skeptics http://www.skeptics.com.au To email me use my first name only at ratbags.com |
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