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UK "Faked" National Autism Data To Declare MMR Vaccine "Safe"



 
 
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  #1  
Old February 10th 10, 12:10 PM posted to misc.health.alternative,misc.kids.health,sci.med
john[_5_]
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Posts: 822
Default UK "Faked" National Autism Data To Declare MMR Vaccine "Safe"

http://childhealthsafety.wordpress.c...veyautismlink/

UK children are nearly 5 times more likely to have autistic conditions than
adults according to the results of the first ever UK government survey to
assess the numbers of adults with the condition: ["Autism Spectrum Disorders
in adults living in households throughout England - Report from the Adult
Psychiatric Morbidity Survey 2007" The NHS Information Centre.]

But the British public were told instead that the survey shows rates in
adults and children have always been the same so that that vaccines like MMR
cannot be to blame for the increasing rates in children. The UK National
Health Service funded the survey and made these claims.

Survey Authors Couldn't Find Enough Adult Autistics
There were early rumours in 2008 the authors could not find numbers of adult
ASC cases matching numbers in children.

The survey failed to find a single case of an adult with "typical" or
"classic" autism, found in approximately 30% of ASC children. "Typical" or
"classic" autism is a type of ASC controversially claimed in 1998 might be
associated with the MMR vaccine.

The authors also failed to find sufficient adult ASC cases overall - just 19
in 7,451 adults, being "higher functioning" ASCs - mainly Asperger's
Syndrome. This represents an overall rate of just under 1 in 300 potential
adults cases and not the officially claimed 1 in 100 for children.

The authors say that if they had carried out the survey differently they
might have found four times as many adults - a further 46 or 47 ASC cases to
come up with the same figure as for children. Using already estimated data
they claimed to be able estimate-on-the-estimate that the adult autism rate
for the entire UK is the same as in children [1 in 100].

The survey's failure to find adult cases is troubling. The survey's original
design was broadly based calling into question the authors' claims to be
able to estimate for such a large number of claimed-to-be-missed cases. An
unlikely 72% of the adult participants were selected as potentially having
one of four mental illnesses [rather than just ASC]. The study was designed
so that those most likely to have an ASC were interviewed and those unlikely
to were excluded.

Autism In Children Already Higher Than 1 in 100

A problem with the survey is that two recent formal peer reviewed journal
published studies have found the rate in children is not 1 in 100 but much
higher. A 2006 study [Baird] found a rate in children of 1 in 85 and a
recently published study by Baron-Cohen et al of 2005 data found a rate of
ASC's in children of 1 in 64 when children not yet diagnosed were taken into
account. This gives a rate of ASC in children 5 times higher than the 1 in
300 indicated by the survey's results. Neither of these studies are
mentioned in the survey although members of the same team were involved in
the Baron-Cohen study, and Professor Baron-Cohen was a consultant to the
survey.

Impossible for Adult ASC Rate to Be Same as Childrens'
The authors inexplicably also fail to explain how their estimate of ASC
rates in adults is the same as in children when their results show ASC rates
in adults and children are significantly different:-

a.. Aspergers Syndrome rates in adults on these results are 40% higher
than in children;

b.. correspondingly Aspergers Syndrome cases in children compared to
adults would have to have substantially decreased for this to be so;
c.. the rate of "classic" autism has leapt from zero in adults to 30% of
ASC cases in children;
d.. adults with "classic" autism do not exist.
Identical Figures - A Remarkable Coincidence
The addition of the authors' hypothetical "estimated" cases provides exactly
the same rate of 1 in 100 previously accepted for children. This is despite
the authors themselves warning the results should be approached with caution
because of the inaccuracies. In such circumstances if rates were the same
then a similar figure might be expected but not exactly the same one.

The 1% figure for children was stated in pre publicity announcing the start
of survey: University of Leicester to lead audit of adults with autism
Eurekalert 9-May-2008. "Author bias" in favour of finding a pre-determined
figure favourable to the study funder is a well-known phenomenon in formal
medical literature.

Breaching the codes of practice prohibiting the release of national
statistics for government policy purposes the UK National Health Service's
publicity put out to the media on publication of the survey focussed on
claiming ASC rates in adults and children were identical and that therefore
the MMR vaccine did not cause ASCs. This was not the stated purpose of the
survey and the authors make no mention of the vaccine-autism issue. Media
stories included: Autism rates back MMR jab safety Michelle Roberts BBC
Tuesday, 22 September 2009 and Autism just as common in adults, so MMR is in
the clear Sarah Boseley The Guardian Tuesday 22 September 2009.


Survey Does Not Live Up To Its Title
The survey was originally announced to establish the UK adult autism rate
for the first time by finding what were then being claimed to be "missed"
adult cases of autism.

The publicity claimed "The new prevalence study now underway will give the
first ever accurate picture of how many adults have the condition."
[Emphasis added]: University of Leicester to lead audit of adults with
autism Eurekalert 9-May-2008. The purpose was to inform UK authorities in
planning service provision for adults autistics.


The authors used "second-hand" data collected in 2007 which covered only
potential adults cases of Asperger's Syndrome unsuitable for the claimed
purpose. The authors planned an additional part of the survey to collect
data on adults with other ASCs such as "typical" or "classic" autism but
failed to mention this or any resulting data or results in their recently
published survey report. They stated in 2008:-

The prevalence study will make use of new data collected in 2007 by NatCen
and Professor Brugha's team to record the number of adults with Asperger's
syndrome and high functioning autism. There will also be an additional part
to the study on the number of people with autism who have more complex needs
and learning disabilities. The aim of the combined research will provide
good epidemiological information in terms of prevalence and the
characteristics and problems of this group."

University of Leicester to lead audit of adults with autism Eurekalert
9-May-2008.

Many Anomalies
The standard approach under what is called "DSM IV" to diagnose ASC's was
applied but the authors based their assessments on a broader test for ASCs
used in a manner neither accepted or relied by other professionals nor
scientifically validated. Inexplicably the survey's results of the DSM IV
diagnoses were neither used nor published.

The 1 in 100 figure for children is based on formal diagnoses using accepted
methods and published in formal peer reviewed medical literature. The
authors' survey has not been independently reviewed nor has it been assessed
for compliance with accepted statistical standards.


The 19 potential adult ASC cases in 7,451 participants included 17 male and
2 female, a rate of 1 in 8.5 whereas 1 in 5 cases in children are girls.

Other problems with the survey include:-

a.. Inclusion in the study was based on the ability of selected members of
the public to answer questions on the telephone followed by cooperation with
a complex psychiatric assessment. The participants were therefore
self-selecting and appear unrepresentative of the general population
a.. The 19 cases claimed included no one from an ethnic minority, and a
very low rate in females (the ratio of females with ASD is known to be 1 in
5 cases in children, but the survey results indicate it is half that in
adults at 1 in 10)
a.. Cooperation of more than half the 14,000 households approached is a
remarkable and unexplained achievement. The questionnaire screened for
psychotic disorder, Asperger syndrome, borderline personality disorder, and
anti-social personality disorder. Were the participants told this and would
they have participated had they known?
a.. The survey authors give a 95% "confidence interval" to their claim
their estimate of adult ASC rate is the same as in children. A confidence
interval is a measure of trust in the reliability of the results but despite
being the broadly based the survey failed to find the "missing" cases.

b.. The survey results were published despite not having been through peer
review nor verified for conformance to accepted standards for government
statistics

a.. Adults with "typical" autism [associated with the MMR vaccine] remain
missing despite being a category claimed in the prior publicity to be part
of the survey.
Dr Carol Stott commented on the methodology in Age of Autism:-

Whatever claims are made to the contrary this report tells us very little
about the number of adults with ASDs - in England or anywhere else. The main
problems with the study are with (a) case-definition, (b) ascertainment (c)
diagnostic instruments (d) case identification and (e) statistical power.

There is no clearly stated case-definition anywhere in the report. The
cases reported are defined loosely in terms of an initial score on a
shortened unstandardised non-peer reviewed version of ascreening tool
together with a semi-structured clinical interview - the Autism Diagnostic
Observation Schedule (ADOS) - that was not designed to act as a stand-alone
diagnostic instrument.

The sample selected is not representative of the ASD population. All
participants were verbally fluent, living in ordinary households, and able
to complete a self-report questionnaire.

The choice of measurement tools is inadequately justified and badly
referenced. No details are provided, nor are any sources referenced, on the
psychometric properties of the initial screening instrument (AQ-20). The
standardized scoring criteria for the ADOS were not followed (using a total
cut-off of 10 for Communication + Social Reciprocity, rather than three
cut-offs (respectively) of 3, 6 and 10 for Communication, Social Reciprocity
and the two combined). Additionally the authors over state the validity of
the ADOS as a tool for use in adult populations. Module Four (used in the
study) was standardized on a sample of only 70 adults aged between 16 and
44. Ages in the study sample range from 16 - 75.

The technical appendix, which is intended to provide information about the
derivation of the AQ-20 is statistically naïve, unclear and potentially
inaccurate. It is not clear for example, what is meant by the phrase on pg
16 of Appendix C "..once the final set of predictors had been selected, a
regression equation was available for predicting the prevalence of ADOS."
Neither is it clear whether General Linear Modelling, Linear Regression or
both were used to derive final items.

Finally, inferences are made about the lack of a significant association
between age-groups and ASD prevalence without reference to statistical
power. In a study of this size, with only 19 identified (unweighted) cases,
the likelihood is that the study was underpowered to detect such
differences.

A valid and reliable study of the population frequency of a disorder
requires clear and robust case definition, validated instruments,
standardized procedures and adequate statistical power. An initial
evaluation of this report suggests it fails on all counts.


  #2  
Old February 10th 10, 05:51 PM posted to misc.health.alternative,misc.kids.health,sci.med
Peter Parry
external usenet poster
 
Posts: 176
Default UK "Faked" National Autism Data To Declare MMR Vaccine "Safe"

On Wed, 10 Feb 2010 11:10:01 -0000, "john" wrote:


UK children are nearly 5 times more likely to have autistic conditions than
adults according to the results of the first ever UK government survey to
assess the numbers of adults with the condition: ["Autism Spectrum Disorders
in adults living in households throughout England - Report from the Adult
Psychiatric Morbidity Survey 2007" The NHS Information Centre.]


How on earth do you work that out when the report you have mentioned
says :-

"The overall prevalence of ASD in adults in England was estimated to
be 1.0%. Rates were higher in men than women and no association with
age was found. The lack of an association with age means that the data
provides no support for there being an increase in prevalence in
recent decades."

The author of this commentary was John Stone, an active supporter of
Wakefield and a prolific anti-vaccination "activist". Perhaps
deciding the report said something entirely different from reality
should be expected.

Dr Carol Stott commented on the methodology in Age of Autism:-


The evergreen Stott, famed as a foul mouthed harridan and permanent
spokesperson for her employer Wakefield.


 




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