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GarySGoldman wrote: Vaccination of a child with the varicella (chickenpox) vaccine actually introduces into the body a live, attenuated (weakened) varicella-zoster virus which can reactivate at a later time--producing shingles (or herpes zoster). However, the vaccine-strain virus is comprised of the Oka-strain which was derived from a Japanese child. When a vaccinated child in the U.S. encounters one of the U.S. wild-type strains, the vaccinated child may experience a subclincal reaction (with no observable rash) or a breakthrough rash (often less than 50 lesions) due to the encounter with a child with the natural or wild-type virus. It is believed that this occurs due to the dissimilarity between the Oka-strain and wild-type U.S. strain (i.e., the strains are heterologous). The natural virus then becomes the dominant virus in the body that is more likely to reactivate. As an example, I just received an e-mail from a parent whose child was vaccinated at age 1. The child had a breakthrough chickenpox rash at age 3, and now has shingles at age 10. Huh. Gary's right, I'm wrong. It's a live virus vaccine. However, the case you describe is of the wild-type virus reactivating; are there any known clinical cases of the vaccine strain causing shingles? I know I could look this up, I'm just lazy. Beth |
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