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This is a transcript of an interview with Dr Darryl See, Director of the
Institute of Longevity Medicine & Chairman of the Research Division of the American Nutraceutical Association -January 2003 Key quotes from this interview: .. the top three killers account for about 92% of deaths, all directly related to the immune system. .. the top 8 killers in the US. are all related to the immune system. .. by the age of 70, 80% of males have prostate cancer. .. by the age of 60, 40% of women have breast cancer. .. when the immune system is balanced correctly, heart disease can be prevented. .. the use of drugs (ADR - Adverse Drug Reaction) is the #4 killer in Western nations. .. as a purely objective, third-party person, I cannot imagine anyone not taking Transfer Factor. __________________________________________________ _________ Q: You are an associate clinical professor. You have been involved with the World Health Organization in Western Europe; are the Director of the Orange County Institute of Longevity Medicine; you are co-chairman of the research division of the American Nutraceutical Association; and you are also an immunologist and a medical doctor? DS: Yes, I am board certified in immunology, internal medicine, infectious disease and, yes, an MD as well. Q: I see that you have received numerous research grants from Upjohn Pharmaceuticals, Schering Pharmaceuticals, Trinity Biotechnology, Biosphere Tech, Rose Molecular Systems, and so on. Even one from the National Institutes of Health on chronic fatigue syndrome. I suppose the question that a lot of people would have, is why would someone who is an immunologist, start studying nutritional medicine and natural medicine? DS: Yes a nice way to start. I did the straight path of 4 years of college in biochemistry, went through 8 of internal medicine residency and then did an infectious disease fellowship for 2 years, 2 more years of an immunology fellowship, then became assistant professor of medicine at the University of California, rising to associate professor. I also spent a year at the World Health Organization (WHO) in France where I honed my skills in the laboratory and in clinical research in immunological disease so we could really make some progress in those types of diseases. But I had a very important experience when I was with the National Institute of Health (NIH). I would go to an immunology conference every single year. The basic science of immunology is so well known there would be section after section on the basics of immunology, but when it got down to therapeutics, there was nothing, absolutely nothing. So, the bottom line was I learned through this process, and also through seeing patients and trying to apply the drug paradigm to their diseases. I have seen over probably now 10,000 patients with some sort of immunologic disorder, and in a drug paradigm there is really nothing you can do for them basically. Intravenous immunoglobulin is sort of the pride of the pharmaceutical/immunological industry and what is funny is when you go from conference to conference, from year to year, it is always about the intravenous immunoglobulin and different uses, but that is about it. A little talk about interferon, but interferon makes you very sick. A little about interleuken-2 - it is very expensive and very toxic. One month of immunoglobulin costs $2,000 in the US - and they don't work very well. I have worked with literally thousands of patients over the years, with a great sense of frustration that I could not do anything with them. I was involved in clinical research and direct patient care, and I was fortunate enough to have expertise in laboratory medicine as well. I decided I wanted to put those three skills together to see if we could come up with something that would actually help these patients - most importantly - to try to prevent disease. Among the top 10 killers in the US, 8 of them are associated with immunological disorders. The two that are not associated with immunological disorders are #4, which is ADR (adverse drug reaction) deaths, and #8, which is physician mistake. It is a tremendous problem, and there were just no answers. So, I plunged in full-force, and I had to go out of the standard medical paradigm. Because I knew very little about nutrition and natural products, I basically had to teach myself. I was fortunate enough to have studied under some experts and I was able to change my laboratory focus to natural products to see if there was something in the natural product realm that could help the immune system. I published a paper in the Journal of the American Nutraceutical Association in February of 1999 - the results of a 6-year study done at the University done from 1992-1998, looking at 196 promising natural products for immune system activity on the body. I will explain a little more about that in a moment. There was nothing spectacular on the list, although there were some natural products that were promising that would raise the immune system. I think the leading natural product after that study was inositol hexophosphate which all of you may recognize as an ingredient of Transfer Factor Plus, which I am delighted to see in there because it is a fantastic immune modulator. That was about the best we had. Also mannans were very nice immune modulators, and I am very happy to see those in Transfer Factor Plus too. After doing five independent studies of transfer factors, it is clear to me that the Transfer Factor Plus product from 4Life has got to be the best immunologic modulator we have. Let me explain immunomodulation. It is an extremely important point. We tend to think of the immune system as "lets get the immune system as boosted-up as we can." People tend to have low immune systems because of environmental factors. For example, there is an ozone hole right over most of Australia that leads to a very high incidence of melanomas there and also really devastates the immune system. We have some Australian connections - one of our cancer patients is a CEO of a big Australian company. He was given three months to live, and yet he is doing very well right now. I will talk about that in a moment. In 2002, we looked at not just 196 natural products that showed promise - we looked at over 500. We have a very standardized, well-validated, highly accepted way of looking at products for efficacy in immunologic disorders. Remember, the top 8 killers in the US - and that would be the same for the whole western world - are all related to the immune system. Having an immune modulator as a part of a regimen is crucial for prevention. It improves the body's ability to fight off chronic infections, cancers, immunologic disorders associated with diabetes. Those would be the top three killers. Interestingly enough there is a very big immunologic component in heart disease as well, and that's the number one killer. Although it's anticipated that by the year 2005, cancer will be the #1 killer in the western world. I am going to give you something you may want to write down. There was an incredibly important paper recently published in Lancet, one of the most highly respected medical journals. The study was from Japan, a 10-year study by Saitama Center Cancer Study Group called "Increased Risk of Cancer in Persons with Decreased Immune Functions" Lancet 2000 vol 356 pp. 1795-1799. That was the first time in history, believe it or not, that a long-term prospective study has ever shown that persons with decreased immune system are at higher risk of developing cancer and get worse cancers than people with normal immune systems. So, all of a sudden the immune system just jumps up to the forefront because when you look at western nations, cancer is becoming rampant. There is hardly a family that does not have cancer, or knows a friend that has cancer. The statistics are just grim. By the age of 70, 80% of males have prostate cancer. By the age of 60, 40% of women have breast cancer. The statistics are just devastating. And then there's the relationship with heart disease - the #2 killer. When the immune system is balanced correctly, heart disease can be prevented. The #3 killer is diabetes, which we are very interested right now and as it turns out, by mechanisms that we are just finding out in the laboratory now, Transfer Factor also lowers blood sugar levels in diabetics. It looks like it is a very nice adjuvant for your patients that have diabetes. As a matter of fact, there is a little bit of literature out that suggests that transfer factors may have some benefits with diabetes. So these are the top three killers in the western world accounting for about 92% of all deaths, all of them directly related to the immune system. This new study from Japan has shown us in blinking huge red lights that we have got to do something about the decreased immune system that we find in the general population or we are going to have a disaster on our hands, which we are indeed already seeing. I don't know how medicine is in Australia, but it is a disaster in the US. 17% of gross-national product goes into the medical care and yet a survey has just shown that 70% of all Americans are dissatisfied with their healthcare. There is something very wrong there. I totally believe that the new paradigm in medicine is using natural products which are not toxic. The use of drugs is the #4 killer in Western nations. Over 108,000 deaths, just in the US, are associated with using too many drugs, drug interactions, etc. Drugs are poisonous, not that they are not useful in some situations, but when we are talking about immunologic diseases, they have very little role and there is very little progress. But in the natural realm there is tremendous progress. As we were looking at the ability of natural products to modulate the immune system we were sent Transfer Factor to evaluate. We found that regular Transfer Factor improved Natural Killer (NK) cell functions by about 100%. It doubled NK cell function in people. We had never seen anything like that. The closest we had seen to that was about a 48% increase with inositol hexophosphate, and mannans were about 47-48%. So this was a huge find for us - we were actually stunned. We repeated that test about 10 times. Subsequently we have repeated that test in cancer patients and in chronic fatigue syndrome patients. So, not only have we done it in the laboratory we have also performed it in patients. Those two studies have now been submitted for publication and they are being peer-reviewed right now at very high-level journals. Hopefully we will have those out within 2-6 months so everybody can see these studies that we have come up with. Even more to our surprise, Transfer Factor Plus increased the NK cell function by 250%. There was a synergy between the different components of TF Plus. In other words, when you take all of the components of Transfer Factor Plus 1+1+1 does not equal 3. 1+1+1=4. That process is called synergy. In other words the products work together to have an enhanced effect on the immune system. Particularly with NK cells. NK cells are the primary defense against chronic infections, viruses in particular, intracellular bacteria, which are associated with a large number of disease. Now we know that intracellular bacteria are associated with rheumatoid arthritis, which is a devastating disease. We know that viruses are associated with diabetes and with heart disease. Viruses are associated with many cases of cancer, with chronic lung disease, and the list goes on and on. It makes sense that if we can improve the function of the NK cells, which help to balance the immune system for one, and to rid the body and protect the body from chronic infections, that the infection rate and the disease rate will go down. We have indeed seen that and that is part of our publication that will be coming out. It is important to understand that there are, in the natural realm, a fair number of products that purely boost the immune system. You will see labels that say 'boosts the immune system,' 'greatly augments the immune system,' etc. This is a very dangerous concept. I want to briefly introduce you to the concept of immune modulation versus immune boosting. Immune modulation means that the immune system is appropriately balanced to address the disease at hand, to prevent recurrence and to protect the body against disease. Because, if you just use pure immune system boosters, it has been shown by scientific studies, that the risk of autoimmune disease goes up. I don't think it takes a rocket scientist to figure that out. If you are boosting everything, then you are going to start attacking parts of your body and indeed that happens. But, that does not happen with Transfer Factor. Transfer factors are composed of two primary populations, an immune boosting population, and an immune suppressing population. They are intelligent. They are encoded for our DNA and they are intelligent transfer factors that work together. They know when the suppressor functions should come in to play to assist with rheumatoid arthritis or some autoimmune disease. As a matter of fact, my uncle had rheumatoid arthritis. He is amazed now that six months later, he is completely free of rheumatoid symptoms whatsoever, just taking Transfer Factor and multivitamins. The Biovitamins that 4Life have available are very very excellent. I think everyone should take those as well because we are almost all deficient in vitamins and minerals as well. This is the concept of immune modulation and there are very few immune modulators that exist. There are certainly none, absolutely zero, in the drug realm. In the non-drug realm there are only a couple. As a matter of fact, one of them is mannans, which is in Transfer Factor Plus. 4Life have covered it very nicely. And, among immune modulators, there is the strongest immune modulator, Transfer Factor Plus, that we have found so far and the second strongest is Transfer Factor itself. This is very impressive to us. When testing, we start off with the early studies - then companies will usually come back to us and ask if we want to extend our studies and usually we do not. But, in the case of Transfer Factor, we extended into a large cancer study and the results were quite remarkable using Transfer Factor Plus. The immune system plays a huge part in prevention of cancer, in the active phase and in prevention of recurrence. And reminding you that this is the number one killer. It also has a very interesting positive effect in preventing heart disease and diabetes, again the 1,2 and 3 killers. From Japan - the Saitama Cancer Group in the Lancet 2000, vol 356 - we know for sure now that persons with decreased immune function - and that immune function is defined as NK cell function (I just wanted to make sure you know that and that is what we are studying in particular, patients that are in that category, whether it be from toxins, drugs, genetics, it does not matter, are at an increased risk of cancer, sometimes a very dramatic increased risk of cancer) - that if you increase their NK cell function, which is the primary defense of the body getting cancer - the risk of cancer goes down. Even as a purely objective, third-party person, I cannot imagine anyone in the world not taking Transfer Factor. I could not imagine that you would not do it. Because, the effect on the immune system is so remarkable, that we have not seen anything else that equals it. The protection that it gives us if we are not sick is remarkable, and if we are sick it will help because there is bound to be an immunological component of one disease. After a disease has "gone", you have to continue because diseases do recur. We have shown that as well, you must continue. This is not a statement that the FDA has evaluated, etc, I need to make that clear to you. But, from our five independent studies, this is a conclusion that we have certainly made. The second important point is that transfer factors, since they have suppressor and booster functions, are immune modulators. They are therapeutic in persons with autoimmune diseases because they know how to interact with each other and suppress the immune system where appropriate, and boost the immune system where appropriate in people with autoimmune disease. So it is safe in any person, even transplant patients. I get that question a lot, with people with heart transplant or liver, are transfer factors safe? Yes they are because they are immune modulators. T-cells that are typically activated that cause rejection in tissues are not activated in autoimmune diseases and transplants, so they are perfectly safe. There is another extremely important point I want to make. There is no way you can possibly get toxic from taking transfer factors. We have gone up to extremely high concentrations, up to the equivalent of someone taking 100 bottles of TF in a one hour period without any toxicity whatsoever. This is an ideal product for lay persons to go out and really make an impact, a positive impact, on the health crisis that we are seeing on a world-wide basis, in regard to degenerative diseases. It is safe in their hands. I am very scared of some products that are floating around in laypersons' hands that are not safe. This is another safe point to take home, you cannot hurt anyone with it. You don't have to know anything about disease. You cannot help but help them. If someone is well, you just cannot help but to help them to prevent disease. That is why I would like everyone to have that Lancet study and to know that Lancet study to give to people. You show them two studies. One has already been pretty well circulated where I have shown that TF Plus and TF increase the immune system to unprecedented levels, and when you put that together with that study it is very easy to make the connection that the risk of cancer is going to be much lower in someone that is improving their immune system and this is a very safe easy way to do this. So, that kind of encapsulates our first study, those main points. There were other points, and we have those in for the publication, but those are the main points. Then we did a huge study looking at cancer patients that were given up by their doctors with an average of about 5 ½ months survival period of time. Now we are about 9 months out and we would expect statistically that about 4-5 of those patients would be barely alive, but as it turns out 16 out of the 20 patients that are taking Transfer Factor Plus are doing extremely well. They are either in remission, stable or getting better. It is a pretty remarkable study. It is a 42 page study that I sent to a very prominent cancer journal and hopefully we will get it in there. It was very carefully done. I am very excited about it. There is absolutely no doubt, based on the Japanese data that when it comes to cancer that Transfer Factors will help prevent cancer and when a person has cancer, whatever the doctor is doing, you will help that person. If that person is getting chemo or radiation, you are not going to decrease the efficacy of that chemotherapy or radiation, or whatever, you are going to help the immune system fight that cancer because cancers release toxins that suppress the immune system. I am not going to go through all of the mechanisms, but there are actually about five ways that TF Plus and two or three ways that TF work to destroy cancer cells. They do not do it just by boosting the immune system. They do some pretty amazing things inside the cells too, like increase apoptosis, which is program cell death, which we want to see in diseases like cancer. So, this is our second very large study. We have recently done another study where we looked at macrophage function. Macrophages are another type of immune cell that are not as important as NK cells, but they are important in viral infected cells, particularly in bacterially-infected cells. We found a very nice boost in macrophage cells as well. And again in levels up to that we had not seen before. This was an important nice study because we did it in a blind fashion. We were given three different products, three transfer factor or colostrum related products and we were not told which was which. And we did the test. One was far superior to the others and that turned out to be 4Life's Transfer Factor Plus and Transfer Factor. It's very hard to argue with a blinded study. I am working on that one right now. There are two that I sent at least a month ago for publication and it is usually about an 8 week period of time. There, in the coming weeks, we are going to be talking a lot more and I will go into more detail about immune modulation, about the papers, how TF works, when to use it, when to not and those types of things. I just wanted to give you an introduction today and just conclude, so we have some time to answer some questions, with a very intriguing area that I am very interested in right now, and that is in diabetes. Diabetes is the most common degenerative disease in the world right now. It is growing every year. It causes a tremendous amount of complications in the heart, kidneys, legs, nerves, and eyes and as it turns out the therapy for diabetes, insulin, is toxic to the body. Insulin causes heart disease and it is very difficult, in fact impossible, to modulate (to make sure the amount of insulin in the body is just right so that it does not have deleterious effects.) Insulin has been shown clearly to age the body quickly, to have negative effects on the cells, heart, kidneys, etc, when it is imbalance. We are finding now, and when I went back into some old literature I was amazed, people have found this before that transfer factors do help people with diabetes. We will keep that as a subject for some other time. But I just wanted to mention it now too because you might see some pretty amazing things if you let a person stay on their insulin and oral hypoglycemics. You are not going to hurt them at all if they try some transfer factors. A warning here - they may have to go way down on their medication after about 1-3 months. We see that all of the time. As a matter of fact, I got called to the Emergency Room twice on patients that I started TF on because by that time I had done some insulin-receptor studies and I was thinking this just may be of some help, it certainly is going to help them prevent other chronic diseases. Then the person feels so much better that they stop looking at their glucose levels, they stop doing their finger pricks, or urines or whatever and the hospital called and their blood sugar was in the 20s-30s. It had dropped so much because of the transfer factors. I will have a lot more information about that over the next couple of months. That will be the sixth study that we will have. Basically it's important for you to know that you have a product that has been proven by our studies so far to be non-toxic, no drug interaction, to boost the part of the immune system that fights diseases while at the same time decreasing the part of the immune system that causes autoimmune disease and graft rejection. Combining that with the Japanese study, we have a product here that boosts the main defense against cancer to such a high degree that, although we have not had time to prove it completely in a prevention sense, TF and TF Plus are extremely important to cancer and any cancer patient. I would use them. During our last conference call, I kind of blew everybody away because everyone asked me for a list for the products that I would recommend. As it turned out, 4Life was coming out with a product called RiteStart that had the exact ingredients in the right combination that are the most effective in cancer, so I was very happy to see that. Q: What would you start a diabetes patient on? DS: There are three products 4Life have and one product that you don't have yet, but I am talking to your scientific people, but it is a simple product you can get from a healthfood store. So, four products for diabetics. One warning: A diabetic person needs to monitor their blood sugars because the blood sugars can certainly go down. I always pick TF Plus for diabetic patients who tend to get infections. Those diabetics who are trying to stay well, just TF would be good enough, about 6 a day would be fine. Diabetics are always deficient in Vanadium, in chromium, vit C, and vit E, and zinc in particular. Those are absolutely crucial in cellular function that lead to complications in diabetes. You cannot just pop 6 TF and get better necessarily. Three bio-multivitamins a day would be very recommendable. There is another product that is fantastic at lowering blood sugar called gynema sylvestre. 4Life have this product (Gurmar). The third product I know is available in Australia is alpha lipoic acid. There is a little of this in the Biovitamins, but not enough for diabetics. You need 200 mg of alpha lipoic acid. So I would go with 6 TF or TF plus, three BioVitamins and 200 mg of alpha lipoic acid and I believe you will see some amazing things. If things are complicated (eg diabetic neuropathy), that has to be handled a little differently, or kidney failure, already the eyes are starting to get shot, or the heart, etc. I will give you a number; I am not trying to plug the clinic, but if you call 949-645-8100 ext 3 you will get me or my partner and leave a message, we will call you back and we can set up a consultation and we can set up other products that will work in combination with those to particularly not drop the sugars, but to prevent complications. 4Life Distributors, without any risk whatsoever, can certainly go ahead and recommend TF, TF Plus, the BioVitamins and the alpha lipoic acid. These will do amazing things. That is what you can start doing right now to help your diabetic patients. Q: Dr. Michael Woolridge, who is the Australian Federal Health Minister, is just retiring. He has been on the Federal Health Ministry for about 5 ½ years, and here's something he stated at a national press conference on the 25th of October of this year. He said that we do have a choice in health care. It is between the vision of focusing on outcomes, focusing on managing disease, focusing on fixing the practical problems people experience day to day in the challenges with health - or a vision focused on monolithic hospitals, that are in essence sickness-based rather than wellness-based. DS: Absolutely. In the chronic degenerative disease we've talked about, which covers most of the immunologic disease, all western medicine can really do is put bandaids on it. Those bandaids are really expensive bandaids, but it does not get down to the root of the problem. Transfer factors bind to receptors and they increase cyclic A&P levels. We know what they do inside the cells. We are improving cellular health in the immune system and other tissues that are biochemically very sound, so you make an excellent point that we are addressing diseases now which is part of the paradigm shift from a wellness perspective, which is getting cells healthy rather than poisoning systems and just trying to control symptoms. Medicine has to head in that direction, and certainly is. But we're going to have a big fight with the systems that are already in place. But patient demand is big. When people start throwing away insulin syringes, we are not making any claims or anything, but when we start seeing cancer incidence going down, then hopefully patients are going to start driving the system. We are seeing that just beginning in the States right now. It is going to free up so much money that is otherwise wasted and also get to the bottom line with patients to help them from a cellular level instead of just putting a bandaid on them. Shifts come hard sometimes, but this is just too important and the science is too overwhelming. We have so much objective data, you have probably just a little bit of the data that we have put out and 4Life has put out, but now with the publications I have sent out we are going to have tremendous amounts of objective data. Q: What would you recommend for chronic fatigue syndrome? DS: I have had thousands of chronic fatigue patients. Chronic fatigue is difficult to do in 30 seconds. But I can quickly cover the important points. 1) It is a variety of diseases. So it is crucial that you get yourself an expert that can rule out testosterone deficiencies, immune deficiency. I would say about 60% of chronic fatigue patients have natural killer deficiency, about 40% have testosterone deficiency, about 30% have pregnenalone deficiency, about 40% have Mycoplasma incognitos superinfection which mannans works absolutely fantastic against that. It is unbelievable. So, first thing to do is to realize it is not one disease. You have to get into an expert and get the right testing done so the expert can get the right testing done to be led in the right direction to give that person the very best combination. 2) The second point to make is this. All chronic fatigue syndrome patients by definition have some kind of immune deficiency, so you cannot help but to do them good to give them transfer factor and for reasons that I will go into later, I would give CFS patients just regular transfer factor, not TF Plus, unless they have Mycoplasma incognitos. I know that is kind of complicated. TF by itself unless they have Mycoplasma, then TF Plus. It took 12 years for me to figure that out but it really holds true. Make sure you get the right workup and transfer factor is going to be helpful no matter what. 3) Every chronic fatigue syndrome patient is vitamin deficient, across the board. The always have mineral deficiency - always have malnutrition. So the BioVitamins help that for sure. All females with chronic fatigue have hormonal deficiency and soy isoflavones, which is in the 4Life Genestein Plus, are extremely beneficial in the hormonal deficiency. If you are a male take the multivitamin, the TF or TF Plus, the BioEFA, and if you are female also take the BioGenistein and then based on the lab results you will probably end up on some other things as well. In a nutshell, that is a start to handling chronic fatigue syndrome. For more info- www.storesonline.com/site/tfplus |
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