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Benefits of Antidepressants Outweigh Risk of Suicidal Behavior inAdolescents
http://www.sciam.com/article.cfm?cha...E93672&ref=rss "We wanted to look at benefit and risk," says epidemiologist Jeffrey Bridge of the Columbus Children's Research Institute, lead author of the study, published online today by JAMA The Journal of the American Medical Association. "The FDA should continue to monitor the safety of these medications, [but] at some point we may want to revisit or reconsider the black box warning." Bridge and colleagues reviewed data from 27 published and unpublished clinical trials in which patients younger than 19 years of age took antidepressants for depression, anxiety or obsessive-compulsive disorder (OCD). All were randomized studies that compared the effects of placebos with one of several medications, including the selective serotonin reuptake inhibitors Prozac, Paxil and Zoloft as well as others, during the first four months of treatment. The team found no reported suicides, but 3 percent of those taking the drugs reported suicidal behavior compared with 2 percent of those taking a placebo. FDA researchers had found rates of 4 and 2 percent, respectively. |
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