Hales Lookup Please

A friend of mine has Generalised Anxiety Disorder, but was not on (and did not
require) medication during pregnancy. In case she has a flare-up, can someone
give me the details about Effexor and bfing?

--
Chookie -- Sydney, Australia
(Replace "foulspambegone" with "optushome" to reply)

"Jeez; if only those Ancient Greek storytellers had known about the astonishing
creature that is the *Usenet hydra*: you cut off one head, and *a stupider one*
grows back..." -- MJ, cam.misc

L3 - no adverse reactions noted in "an excellent study involving 3 mothers"
for the infants.

The rest of it just talks about plasma/ratios etc. Numbers...if you want me
to post let me know...
"Chookie" wrote in message
...
A friend of mine has Generalised Anxiety Disorder, but was not on (and did
not
require) medication during pregnancy. In case she has a flare-up, can
someone
give me the details about Effexor and bfing?

--
Chookie -- Sydney, Australia
(Replace "foulspambegone" with "optushome" to reply)

"Jeez; if only those Ancient Greek storytellers had known about the
astonishing
creature that is the *Usenet hydra*: you cut off one head, and *a stupider
one*
grows back..." -- MJ, cam.misc

CY wrote:

L3 - no adverse reactions noted in "an excellent study involving 3 mothers"
for the infants.

**THREE** mothers?

Dawn

I know, I thought that was a bit lame too!
"Dawn Lawson" wrote in message
news:kdmQb.242535$JQ1.166885@pd7tw1no...


CY wrote:

L3 - no adverse reactions noted in "an excellent study involving 3
mothers"
for the infants.

**THREE** mothers?

Dawn

In article AklQb.39958$Xq2.33904@fed1read07, "CY"
wrote:

L3 - no adverse reactions noted in "an excellent study involving 3 mothers"
for the infants.

The rest of it just talks about plasma/ratios etc. Numbers...if you want me
to post let me know...

Please do! I don't think my friend will be impressed with a study with n=3!

--
Chookie -- Sydney, Australia
(Replace "foulspambegone" with "optushome" to reply)

"Jeez; if only those Ancient Greek storytellers had known about the astonishing
creature that is the *Usenet hydra*: you cut off one head, and *a stupider one*
grows back..." -- MJ, cam.misc

Okey Dokey - here goes:

Venlafaxine is a new ssri antidepressant. It inhibits both serotonin
reuptake & norepinephrine reuptake. Somewhat similar in mechanism to other
antidepressants such as Prozac. Fewer anticholinergic side effects.

In an excellent study of 3 mothers (mean age=34.5 yrs, 84.5kg) receiving
Venlafaxine (225-300 mg/d) the mean milk/plasma ratios for Venlafaxine and
O-desmethylvenlafaxine
(ODV) were 2.5 & 2.7, respectively. The mean maximum concentrations of
Venlafaxine and ODV in milk were 1.16 mg/L & 0.796 mg/L. The Cmax for milk
was 2.25 hours. The mean infant exposure was 3.2% for Venlafaxine and 3.2%
for ODV of the weight adjusted maternal does. Venlafaxine was detected in
one of the seven infants, while ODV was detected in 4 of the 7 infants. The
infants were healthy and showed no acute adverse effects.

Pregnancy risk:C
Lactation Risk:L3
Theoretic Infant Dose: 647.9ug/kg/day

Adult Concerns: Nausea/Vomiting, somnolence, dry mouth, dizziness, headache,
weakness

Ped Concerns: None reported via milk, but no studies are available.

Drug Interactions: Serious sometimes fatal reactions when used with MAO
inhibitors, or if used within 7-14 days of their use.

Alternatives: Sertraline, Paroxetine

T 1/2 (HALF-LIFE) = 5 Hrs
pk (Peak)= 2.25 Milk
MW (Molecular Weight - less than 200 means easily passed to milk)=313
Vd (volume of distribution - how widely it's distributed in the body - lower
than 1 is pref) =4-12 liters/kg
PB (Protein Binding - the higher the better)=27%
Oral (Oral Bioavailability)=92%
pKa (the lower the better, pref 7.2 or less)=9.4

I don't really know anythng about any of this stuff but just posted verbatim
what the book says in it's entirety. HTH!

CY


"Chookie" wrote in message
...
In article AklQb.39958$Xq2.33904@fed1read07, "CY"

wrote:

L3 - no adverse reactions noted in "an excellent study involving 3
mothers"
for the infants.

The rest of it just talks about plasma/ratios etc. Numbers...if you
want me
to post let me know...

Please do! I don't think my friend will be impressed with a study with
n=3!

--
Chookie -- Sydney, Australia
(Replace "foulspambegone" with "optushome" to reply)

"Jeez; if only those Ancient Greek storytellers had known about the
astonishing
creature that is the *Usenet hydra*: you cut off one head, and *a stupider
one*
grows back..." -- MJ, cam.misc