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Vaccinations & Autism & Breast Implants & Genetics ............
Mark Probert claimed:
Even so, since I feel that autism is 99% genetic, there would be no issue for me. Mark, this quote quite touched me. Let's say, in a peaceful moment, that you are absolutely correct ... ... autism is 99% genetic Maybe that's true ... Yet you seem to not understand that these genetics are what would determine one's propensity and sensitivity to the mercury in vaccinations. It is our genetics that determine how we respond to various toxins and poisons ... some people are extremely sensitive to mercury. My father was ... he could break out and practically go into shock just being in the same house with a broken thermometer ... One time my dentist sent me home with a cute little rolly silver glop of mercury ... probably 50 years ago ... and my father had a very serious reation when the rest of the family did not. He didn't touch it ... my siblings and I played with it. He walked into the house and his eyes were swelling up in moments. I hope you understand this ... I believe there is a subset of children who will react very severely to mercury being shot inside their young bodies ... I don't know what percentage and I doubt either do you. But it exists. Some day I believe that genetic testing will be available to determine who can benefit from ... and who will have serious reactions to various vaccinations. I believe the same for breast implants by the way ... that a subset of women are genetically programmed in such a way to react very negatively to foreign objects ... especially ones with platinum and silica and other toxic ingredients. In both vaccinations and breast implants, there are so many chemicals and substances that various people, programmed by their genetics, will respond differently to those substances. Leroy Young, an aggressive Plastic Surgeon from Missouri did what I consider one of the most important studies way back in 1995 ... I've posted it below. In these next 11 years enormous strides could have been made, yet I have seen no follow up. Instead, Young, unaffectionately known as Leroid Young, developed and advertised and experimented with very dangerous soy filled implants .... a disaster beyond imagination. I feel strongly that scientists (not Junk Scientists like Young who apparently dropped the ball on this important research and now pushes butt implants) need to look further into HLA genotypes as discussed below. Shabbot Shalom. Ilena Rosenthal www.BreastImplantAwareness.org ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ~~ DR53 may be a marker of women who are predisposed by their HLA genotype to develop symptoms following exposure to silicone gel breast implants. Young VL ; Nemecek JR ; Schwartz BD ; Phelan DL ; Schorr MW ; Department of Medicine, Washington University School of Medicine, St. Louis, Mo, USA. Plast Reconstr Surg Vol. 96 no. 7 pp. 1497-519; discussion 1520 DATE: 1995 Dec Abstract Since the 1970s, anecdotal reports have described a relatively small number of women who received silicone gel breast implants and later developed either a recognized rheumatologic disease or unexplained symptoms suggestive of an autoimmune disorder. The study reported here examined whether there is any association between the symptoms seen in implant patients and HLA molecules. One-hundred and ninety-nine subjects were evaluated by HLA typing: symptomatic patients with implants (group I, n = 77), asymptomatic women with implants (group II, n = 37), healthy female volunteers without implants (group III, n = 54), and fibromyalgia patients without implants (group IV, n = 31). A statistically significant 68 percent of group I were positive for HLA-DR53, compared with 35 percent of group II and 52 percent of group III. The fibromyalgia patients were strikingly similar to group I women in terms of HLA-DR molecules, with 65 percent of group IV being positive for DR53. Group I also had a statistically significant increased frequency of HLA-DQ2. Asymptomatic women with implants (group II) had an increased frequency of DR1 and DQ1. In addition, 42 percent of symptomatic patients with implants formed autoantibodies to their own B cells; of these, 81 percent were DR53-positive. Although frequencies of capsular contracture and implant rupture were not significantly different in the two groups with implants, there were statistically significant associations in group I between contractures and ruptures and the presence of DR53 and B-cell autoantibodies. These data suggest that symptomatic patients with implants share important genetic characteristics (primarily HLA- DR53 positivity) that differentiate them from their asymptomatic counterparts. DR53 may be a marker of women who are predisposed by their HLA genotype to develop symptoms following exposure to silicone gel breast implants. Young VL ; Nemecek JR ; Schwartz BD ; Phelan DL ; Schorr MW ; Department of Medicine, Washington University School of Medicine, St. Louis, Mo, USA. ~~~~~~~~~~~~~~~~~~ Some Women With Breast Implants May Be Genetically Predisposed to Illness by Caroline Decker Contact: Washington University School of Medicine in St. Louis Caroline Decker 314-286-0109 Anecdotal reports of illness by some women with silicone gel breast implants eventually led the federal Food and Drug Administration in 1992 to ban their use pending a safety review. However, researchers still do not know why some women with implants, and not others, develop symptoms suggestive of an illness. Now, a study by researchers at Washington University School of Medicine in St. Louis concludes that genetic factors may play a role. The study found that women with breast implants who had debilitating symptoms such as chronic fatigue, burning breast pain, muscle or joint pain were more likely to share genetic characteristics that differentiate them from women with breast implants who have no symptoms. "To our surprise, we found that some women with implants may be genetically predisposed to develop symptoms," said lead researcher Leroy Young, M.D., a plastic and reconstructive surgeon at Washington University School of Medicine. Moreover, the researchers found that women with breast implants and symptoms also were more likely than others in the study to produce autoantibodies against their B cells. B cells are a key component of the immune system, and high frequencies of such autoantibodies are clearly abnormal, Young said. "Autoantibodies to B cells may hold clues that will help explain why some women with breast implants develop symptoms," he said. The team reported its findings in the journal of Plastic and Reconstructive Surgery in December 1995. Since the FDA ban, researchers have tried to explain the origin of symptoms reported by some women with breast implants. The lack of a recognized disease in these patients and the failure to find a cause for their symptoms prompted Washington University researchers to conduct the study. The researchers studied the genetic characteristics of 199 women -- 77 with breast implants and symptoms, 37 with implants and no symptoms, 54 healthy women without implants and 31 women diagnosed with fibromyalgia, a disease defined by pain in connective tissues such as muscles, tendons and ligaments. Fibromyalgia is not known to be immune-mediated and has no known cause. Women with fibromyalgia were included in the study to determine whether women with breast implants are prone to develop the rheumatological disorder. Symptoms of fibromyalgia are similar to those experienced by women with breast implants who develop symptoms. "At first, we thought implants might trigger fibromyalgia," Young said. To be considered symptomatic, women with breast implants had to have one or more of the following: burning breast pain, chronic fatigue, vague upper body pain, muscle or joint pain. Their symptoms must have persisted for at least four months and have interfered with daily activities, particularly with the ability to maintain a job. Women with breast implants and those with fibromyalgia averaged 46 years of age; those in the healthy comparison group were slightly younger, averaging 37 years of age. Virtually all women in the study were white. Genetic characteristics were determined by analyzing blood samples. The researchers zeroed in on a group of proteins encoded by a collection of genes called the major histocompatibility complex (MHC), which is known to play an important role in immune response. They wanted to find out whether the MHC molecules of symptomatic women with breast implants differed from those of women with breast implants who did not have symptoms. The investigators used HLA (human leukocyte antigen) typing to analyze blood samples; organ transplant teams use the same procedure to assess genetic similarities between organ donors and recipients. Molecule Could Be a Marker They found that both women with implants and symptoms and women with fibromyalgia were significantly more likely to have an HLA molecule called DR-53. The molecule was present in 68 percent of symptomatic breast implant patients and 65 percent of fibromyalgia patients, compared with 35 percent of the asymptomatic implant patients. Fifty-two percent of the healthy women also had the DR-53 molecule, which is similar to its natural frequency among white women. DR molecules play a critical immunoregulatory role because they control the interactions among the immune system's T cells, B cells and antigen-presenting cells. Young and his colleagues initially suspected that women with breast implants and symptoms actually had fibromyalgia. But when they looked closer, they found that 42 percent of symptomatic women with breast implants formed antibodies against their own B cells. Only 2 percent of healthy women formed autoantibodies, compared with 14 percent of asymptomatic women with breast implants and 19 percent of fibromyalgia patients. More striking, however, was the observation that 81 percent of the patients with implants who produced autoantibodies were DR-53 positive. This compares with 33 percent of fibromyalgia patients who were positive for both autoantibodies and DR-53. "There's clearly a link between DR-53 and autoantibodies," Young said. "But we won't know what it means until we find out why these women are forming autoantibodies at such a high rate." Women with symptoms had had their breast implants for an average of 12 years, compared with asymptomatic women who had had their implants for an average of 10 years. So it's possible that the latter group may develop symptoms over time. "This may be especially true for those asymptomatic women who are DR-53 positive or who have produced autoantibodies to their own B cells," Young said. Young and his co-workers are now trying to find out what is triggering the production of autoantibodies. If they are formed in response to silicone gel or one of its components, then the asymptomatic implant group also might be expected to have high frequencies. On the other hand, if the autoantibodies are somehow related to the presence of DR-53, the fibromyalgia patients might be expected to have higher frequencies of B cell autoantibodies. "We can't fully explain the highly statistically significant formation of autoantibodies to B cells, but their presence suggests the activation of an immune-mediated process that is related to DR-53 and breast implant exposure," Young said. If the study's results are confirmed, DR-53 could be viewed as a marker for individuals who may be predisposed to develop an immune-mediated response or hypersensitivity reaction following silicone breast implants. But Young cautioned that it is too early for the information to be used clinically and that women with implants should not rush to their doctors and request HLA tissue typing, a test that costs about $1,300. "The test is useful as a research tool but would not be helpful in making clinical decisions," Young explained. "However, women with breast implants need regular follow-ups with their physicians." |
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