Rate of Ritalin induced mania in children

J Child Adolesc Psychopharmacol. 2003 Summer;13(2):123-36. Related
Articles, Links


Response to methylphenidate in children with attention deficit hyperactivity
disorder and manic symptoms in the multimodal treatment study of children
with attention deficit hyperactivity disorder titration trial.

Galanter CA, Carlson GA, Jensen PS, Greenhill LL, Davies M, Li W, Chuang SZ,
Elliott GR, Arnold LE, March JS, Hechtman L, Pelham WE, Swanson JM.

Columbia University/New York State Psychiatric Institute, New York, New York
10032, USA.

OBJECTIVE: Recent reports raise concern that children with attention deficit
hyperactivity disorder (ADHD) and some manic symptoms may worsen with
stimulant treatment. This study examines the response to methylphenidate in
such children. METHODS: Data from children participating in the 1-month
methylphenidate titration trial of the Multimodal Treatment Study of
Children with ADHD were reanalyzed by dividing the sample into children with
and without some manic symptoms. Two "mania proxies" were constructed using
items from the Diagnostic Interview Schedule for Children (DISC) or the
Child Behavior Checklist (CBCL). Treatment response and side effects are
compared between participants with and without proxies. RESULTS: Thirty-two
(11%) and 29 (10%) participants fulfilled criteria for the CBCL mania proxy
and DISC mania proxy, respectively. Presence or absence of either proxy did
not predict a greater or lesser response or side effects. CONCLUSION:
Findings suggest that children with ADHD and manic symptoms respond robustly
to methylphenidate during the first month of treatment and that these
children are not more likely to have an adverse response to methylphenidate.
Further research is needed to explore how such children will respond during
long-term treatment. Clinicians should not a priori avoid stimulants in
children with ADHD and some manic symptoms.

PMID: 12880507 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
--
"Insanity in individuals is something rare - but in groups, parties,
nations and epochs, it is the rule."
Friedrich Nietzsche

While the findings are excellent, your subject line is misleading.



"Sydney" wrote in message
s.com...
J Child Adolesc Psychopharmacol. 2003 Summer;13(2):123-36. Related
Articles, Links


Response to methylphenidate in children with attention deficit
hyperactivity
disorder and manic symptoms in the multimodal treatment study of children
with attention deficit hyperactivity disorder titration trial.

Galanter CA, Carlson GA, Jensen PS, Greenhill LL, Davies M, Li W, Chuang
SZ,
Elliott GR, Arnold LE, March JS, Hechtman L, Pelham WE, Swanson JM.

Columbia University/New York State Psychiatric Institute, New York, New
York
10032, USA.

OBJECTIVE: Recent reports raise concern that children with attention
deficit
hyperactivity disorder (ADHD) and some manic symptoms may worsen with
stimulant treatment. This study examines the response to methylphenidate
in
such children. METHODS: Data from children participating in the 1-month
methylphenidate titration trial of the Multimodal Treatment Study of
Children with ADHD were reanalyzed by dividing the sample into children
with
and without some manic symptoms. Two "mania proxies" were constructed
using
items from the Diagnostic Interview Schedule for Children (DISC) or the
Child Behavior Checklist (CBCL). Treatment response and side effects are
compared between participants with and without proxies. RESULTS:
Thirty-two
(11%) and 29 (10%) participants fulfilled criteria for the CBCL mania
proxy
and DISC mania proxy, respectively. Presence or absence of either proxy
did
not predict a greater or lesser response or side effects. CONCLUSION:
Findings suggest that children with ADHD and manic symptoms respond
robustly
to methylphenidate during the first month of treatment and that these
children are not more likely to have an adverse response to
methylphenidate.
Further research is needed to explore how such children will respond
during
long-term treatment. Clinicians should not a priori avoid stimulants in
children with ADHD and some manic symptoms.

PMID: 12880507 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
--
"Insanity in individuals is something rare - but in groups, parties,
nations and epochs, it is the rule."
Friedrich Nietzsche

--


May those who love us, Love us
And those that don't love us,
May God turn their hearts;
And if He doesn't turn their hearts
May he turn their ankles
So we'll know by their limping

An old Gaelic Blessing


"Markios Probertios" wrote in message
t...

| While the findings are excellent
|

So glad you appreciate the info.
--

May those who love us, Love us
And those that don't love us,
May God turn their hearts;
And if He doesn't turn their hearts
May he turn their ankles
So we'll know by their limping

An old Gaelic Blessing

On Fri, 21 Nov 2003 14:17:25 GMT, "Markios Probertios"
wrote:

While the findings are excellent, your subject line is misleading.

Particularly since the article DID NOT provide information as to rates
in children. I did find the conclussion interesting and that some of
the paranoia abates.

================================================== ==
Ruby stepped toward him. "Edward," she said softly.
"Learn this from me. Holding anger is a poison. It
eats you from inside. We think that hating is a weapon
that attacks the person who harmed us. But hatred is
a curved blade. And the harm we do, we do to ourselves.
"Forgive, Edward, Forgive. Do you remember the
lightness you felt when you first arrived in heaven?...
No one is born with anger. And when we die, the soul
is freed of it. But now, here, in order to move on,
you must understand WHY you felt what you did, and WHY
you no longer need to feel it.
"Yo need to forgive your father."

Mitch Albom, "the five people you meet in heaven"

http://home.gwi.net/~mdmpsyd/index.htm

"Mark D Morin" wrote in message
...
| On Fri, 21 Nov 2003 14:17:25 GMT, "Markios Probertios"
| wrote:
|
| While the findings are excellent, your subject line is misleading.
|
I did find the conclussion interesting and that some of
| the paranoia abates.

The old research on stimulants was flawed because the stimulants were
immediately discontinued in children who manifested tics or mania.

The actual effect of a med is not known until the alterations to the brain
chemistry in reaction to taking it are complete, which takes many weeks.

Stimulants are no longer automatically contraindicated in those with
TS..because the newer clinical trials of stimulants in those with Tic
disorders were one's where the stimulants were not discontinued if tics
manifested or were exacerbated, so it could be discovered that while
stimulants initially triggered or exacerbated tics...after being on the
stimulants the ticcing abated.

The finding that any symptoms of mania triggered or exacerbated by taking
stimulants abate once the alterations to brain chemistry are complete...is
IMO supported by the findings regards ticcing.

This research is more good news for parents of children with Tourettes,
since its any symptoms of ADHD or emotional lability/non-specific mood
disorder which are the impairing one's in TS, not the tics.