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#11
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Dentists Oppose Fluoridation; You Should Too
Professionals Urge End to Water Fluoridation
Below abstract indicates fluoride damages mito in human kidney cells. Fluoride ion toxicity in human kidney collecting duct cells. BACKGROUND: Several halogenated anesthetics induce a urinary concentrating defect, partly related to fluoride ion toxicity in collecting duct cells. The aim of this study was to investigate the effects of fluoride ion in human kidney cells. METHODS: Immortalized human collecting duct cells were used. In a first set of experiments, the toxicity threshold concentration was determined by exposing cell cultures for 24 h to increasing concentrations of fluoride ion in the medium: 0, 1, 5, and 10 mM. The second set of experiments was a time- effect study in which cells were exposed to 5 mM fluoride for 2, 6, and 24 h. Assessment of toxicity was based on several endpoints: cell number, protein content, (3)H-leucine incorporation in newly synthesized proteins, extracellularly released lactate dehydrogenase, Na-K-ATPase pump activity, and electron microscope studies. RESULTS: After 24 h of exposure, fluoride ion decreased cell number (-23%, P0.05), total protein content (-30%, P0.05) and increased lactate dehydrogenase release (+236%, P0.05) at a threshold concentration of 5mM. Fluoride ion also inhibited Na-K- ATPase activity at 5 mM (-58%, P0.05). Major morphologic alterations of mitochondria, including crystal formation, were detected from 1 mM fluoride concentration. Time-effect studies showed that, after only 6 h of exposure at 5 mM, fluoride decreased cell number (-13%, P0.05), (3)H-leucine incorporation (-48%, P0.05), and Na-K-ATPase activity (- 20%, P0.05) and increased lactate dehydrogenase release (+145%, P0.05). Crystal deposits in mitochondria again were a more sensitive marker of cell injury, detectable after only 2 h of exposure. CONCLUSIONS: these results suggest that the mitochondrion is a target of fluoride toxicity in human collecting duct cells, and its alteration is partly responsible for the sodium and water disturbances observed in patients. PMID: 8602675 |
#12
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Dentists Oppose Fluoridation; You Should Too
Professionals Urge End to Water Fluoridation
Below article indicates fluoride renders bunny sperms infertile. Ultrastructural studies of spermiogenesis in rabbit exposed to chronic fluoride toxicity. OBJECTIVE--To address the role of fluoride in causing defects to spermatids and epididymal spermatozoa. METHODS--Male rabbits were treated with 10 mg NaF/kg body weight daily for 18 months and maintained under identical laboratory conditions along with the control rabbits not given NaF. Testis and epididymis (caput) were investigated for ultrastructural details of spermatids and spermatozoa. RESULTS--A wide variety of structural defects were observed in the flagellum, the acrosome, and the nucleus of the spermatids and epididymal spermatozoa of fluoride-treated rabbits. Abnormalities included absence of outer microtubules, complete absence of axonemes, structural and numeric aberrations of outer dense fibers, breakdown of the fibrous sheath, and structural defects in the mitochondria of the middle piece of the flagellum. Detachment and peeling off of the acrosome from the flat surfaces of the nucleus were also observed. CONCLUSION--The abnormalities observed render the sperm nonfunctional and ineffective, and thus there is a possible role of fluoride in causing infertility. PMID: 7920753 |
#13
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Dentists Oppose Fluoridation; You Should Too
Professionals Urge End to Water Fluoridation
There is much more at http://www.fluoridealert.org about fluoride in air, fertilizers, how it kills bees, etc. To sign a petition to end fluoridation, visit http://salsa.democracyinaction.org/o...aign_KEY=21960 |
#14
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Dentists Oppose Fluoridation; You Should Too
#1 Nobody drinks tap water any more, certainly not children.
#2 Anybody who drinks tap water has the option of filtering it. Therefore, Fluoridation of drinking water stopped being an issue some 20 years ago. Just thought that you might want to know. |
#15
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Dentists Oppose Fluoridation; You Should Too
... Fluoridation of drinking water stopped being an issue some 20 years ago.
Following links sites common sources of fluoride: http://www.fluoridealert.org/f-sources.htm#I |
#16
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Dentists Oppose Fluoridation; You Should Too
On Feb 24, 2:26 pm, jay wrote:
... Fluoridation of drinking water stopped being an issue some 20 years ago. Following links sites common sources of fluoride:http://www.fluoridealert.org/f-sources.htm#I Read the f*cking Subject Line. Can the paranoid nut-jobs kindly drop dead? |
#17
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Dentists Oppose Fluoridation; You Should Too
Fluoride FAQ at http://www.fluoridealert.org/faqs.htm
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#18
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Dentists Oppose Fluoridation; You Should Too
On Feb 24, 2:31*pm, Mr-Natural-Health john-h-
wrote: On Feb 24, 2:26 pm, jay wrote: ... Fluoridation of drinking water stopped being an issue some 20 years ago. Following links sites common sources of fluoride:http://www.fluoridealert.org/f-sources.htm#I Read the f*cking Subject Line. Can the paranoid nut-jobs kindly drop dead? Hi John. Rarely do we agree, but here is one time. I saw the nut job NYCOF on CNN a few years ago. He was, of course, discussing flouride. He would not allow the advocate speak. AEvery time the advocate started a sentence, the rude jerk would interupt and cut him off. The CNN talking head was unable to restrain him. And, to think he lives near me. Shudder. OK, back to not agreeing. |
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